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Browsing Research Articles (Medical Microbiology) by Author "Ismail, Nabila"
Now showing items 1-10 of 10
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Ismail, Nabila; Peters, Remco P.H.; Ismail, Nazir Ahmed; Omar, Shaheed Vally (American Society for Microbiology, 2019-03)Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline ...
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Ismail, Nabila; Omar, Shaheed Vally; Ismail, Nazir Ahmed; Peters, Remco P.H. (Elsevier, 2018-10)A comprehensive literature search was conducted to obtain previously published resistance associated mutations for bedaquiline, clofazimine and linezolid for Mycobacterium tuberculosis. Where possible, mutation frequencies ...
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Strydom, Kathy-Anne; Ismail, Farzana; Matabane, M.M.Z.; Onwuegbuna, O.; Omar, Shaheed Vally; Ismail, Nabila (American Society for Microbiology, 2015-09)In a head to head comparison of the MTBDRplus Version 2.0 (Hain Lifescience), Xpert® MTB/RIF (Cepheid) and the Anyplex™ MTB/NTM (Seegene) assays we demonstrate equal sensitivity (59/61; 96.7%) and specificity (53/54; ...
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Moore, B.K.; Anyalechi, E. Gloria; Van Der Walt, M.; Smith, S.; Erasmus, L.; Lancaster, J.; Morris, S.; Ndjeka, Norbert; Ershova, J.; Ismail, Nabila; Burton, D.; Menzies, H. (International Union Against Tuberculosis and Lung Disease, 2015-06)OBJECTIVE : To describe the demographic and clinical characteristics of children and adolescents diagnosed with resistance to any anti-tuberculosis drug (drug-resistant tuberculosis; DR-TB) in South Africa. DESIGN : We ...
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Omar, Shaheed Vally; Peters, Remco P.H.; Ismail, Nazir Ahmed; Jonkman, Kelly; Dreyer, Andries W.; Said, Halima M.; Gwalab, Thabisile; Ismail, Nabila; Fourie, P.B. (Petrus Bernardus) (Wiley, 2016-06)Molecular tests are revolutionizing diagnosis of tuberculosis (TB). Disease burden is concentrated in resource-poor countries with inadequate infrastructure and capacity resulting in delays for specimens to reach the ...
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Ismail, Nazir Ahmed; Omar, Shaheed Vally; Ismail, Nabila; Peters, Remco P.H. (Elsevier, 2018-10)Bedaquiline, clofazimine and linezolid are pertinent drugs for drug-resistant tuberculosis. Drug-resistant mutants provide insight into important resistance acquisition mechanisms. Methods for in vitro Mycobacterium ...
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Ismail, Nabila; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Peters, Remco P.H. (American Society for Microbiology, 2019-08)Bedaquiline resistance within Mycobacterium tuberculosis may arise through efflux-based (rv0678) or target-based (atpE) pathway mutations. M. tuberculosis mutant populations from each of five sequential steps in a passaging ...
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Omar, Shaheed Vally; Peters, Remco P.H.; Ismail, Nazir Ahmed; Dreyer, Andries W.; Said, Mohamed; Gwala, Thabisile; Ismail, Nabila; Fourie, P.B. (Petrus Bernardus) (Elsevier, 2015-10)BACKGROUND : Modern molecular-based approaches for the detection of Mycobacterium tuberculosis in sputum samples promise quicker and more accurate detection of cases. However, processing sputum samples at central diagnostic ...
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Matabane, M.M.Z.; Ismail, Farzanah; Strydom, Kathy-Anne; Onwuegbuna, O.; Omar, Shaheed Vally; Ismail, Nabila (BioMed Central, 2015-11-09)BACKGROUND : A major challenge faced by countries with a high burden of tuberculosis (TB) is early detection especially in individuals with paucibacillary disease which is common in HIV endemic settings. Remarkable efforts ...
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Omar, Shaheed Vally; Joseph, Lavania; Halima M. Said; Ismail, Farzana; Ismail, Nabila; Gwala, Thabisile L.; Ismail, Nazir Ahmed (AOSIS Open Journals, 2019-02-21)South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome ...
Now showing items 1-10 of 10