Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis

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Authors

Omar, Shaheed Vally
Joseph, Lavania
Halima M. Said
Ismail, Farzana
Ismail, Nabila
Gwala, Thabisile L.
Ismail, Nazir Ahmed

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Publisher

AOSIS Open Journals

Abstract

South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.

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Keywords

Treatment, Whole genome sequencing, Mycobacterium tuberculosis (MTB), Tuberculosis (TB), South Africa (SA), Drug resistance

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Citation

Omar SV, Joseph L, Said HM, et al. Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis. African Journal of Laboratory Medicine 2019;8(1), a801. https://DOI.org/10.4102/ajlm.v8i1.801.