Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
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Date
Authors
Omar, Shaheed Vally
Joseph, Lavania
Halima M. Said
Ismail, Farzana
Ismail, Nabila
Gwala, Thabisile L.
Ismail, Nazir Ahmed
Journal Title
Journal ISSN
Volume Title
Publisher
AOSIS Open Journals
Abstract
South Africa remains challenged with a high tuberculosis burden accompanied by an
increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation
sequencing platform for whole genome sequencing, followed by bioinformatic analysis
using a commercial software package to determine resistance to selected drugs used for
Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows
potential as a diagnostic platform for the detection of drug resistance in Mycobacterium
tuberculosis with the provision of information for several drugs simultaneously.
Description
Keywords
Treatment, Whole genome sequencing, Mycobacterium tuberculosis (MTB), Tuberculosis (TB), South Africa (SA), Drug resistance
Sustainable Development Goals
Citation
Omar SV, Joseph L,
Said HM, et al. Whole
genome sequencing for drug
resistance determination in
Mycobacterium tuberculosis.
African Journal of Laboratory Medicine 2019;8(1),
a801. https://DOI.org/10.4102/ajlm.v8i1.801.