Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
| dc.contributor.author | Omar, Shaheed Vally | |
| dc.contributor.author | Joseph, Lavania | |
| dc.contributor.author | Halima M. Said | |
| dc.contributor.author | Ismail, Farzana | |
| dc.contributor.author | Ismail, Nabila | |
| dc.contributor.author | Gwala, Thabisile L. | |
| dc.contributor.author | Ismail, Nazir Ahmed | |
| dc.date.accessioned | 2020-06-15T10:09:07Z | |
| dc.date.available | 2020-06-15T10:09:07Z | |
| dc.date.issued | 2019-02-21 | |
| dc.description.abstract | South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously. | en_ZA |
| dc.description.department | Medical Microbiology | en_ZA |
| dc.description.librarian | am2020 | en_ZA |
| dc.description.sponsorship | Funding was provided by the National Institute for Communicable Diseases, a division of the National Health Laboratory Service, South Africa. | en_ZA |
| dc.description.sponsorship | The National Institute for Communicable Diseases, a division of the National Health Laboratory Service, South Africa | en_ZA |
| dc.description.uri | http://www.ajlmonline.org | en_ZA |
| dc.identifier.citation | Omar SV, Joseph L, Said HM, et al. Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis. African Journal of Laboratory Medicine 2019;8(1), a801. https://DOI.org/10.4102/ajlm.v8i1.801. | en_ZA |
| dc.identifier.issn | 2225-2002 (print) | |
| dc.identifier.issn | 2225-2010 (online) | |
| dc.identifier.other | 10.4102/ajlm.v8i1.801 | |
| dc.identifier.uri | http://hdl.handle.net/2263/74994 | |
| dc.language.iso | en | en_ZA |
| dc.publisher | AOSIS Open Journals | en_ZA |
| dc.rights | © 2019. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. | en_ZA |
| dc.subject | Treatment | en_ZA |
| dc.subject | Whole genome sequencing | en_ZA |
| dc.subject | Mycobacterium tuberculosis (MTB) | en_ZA |
| dc.subject | Tuberculosis (TB) | en_ZA |
| dc.subject | South Africa (SA) | en_ZA |
| dc.subject | Drug resistance | en_ZA |
| dc.title | Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis | en_ZA |
| dc.type | Article | en_ZA |