Browsing Research Articles (Medical Virology) by UP Author "Mayaphi, Simnikiwe Horatious"

Browsing Research Articles (Medical Virology) by UP Author "Mayaphi, Simnikiwe Horatious"

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  • Cytomegalovirus viral load kinetics in patients with HIV/AIDS admitted to a medical intensive care unit : a case for pre-emptive therapy 
    Mayaphi, Simnikiwe Horatious; Brauer, Marieke; Morobadi, Daniel M.; Mazanderani, Ahmad Haeri; Mafuyeka, Rendani T.; Olorunju, Steve A.S.; Tintinger, Gregory Ronald; Stoltz, Anton Carel (Public Library of Science, 2014-04-03)
    BACKGROUND : Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there is a lack of data for pre-emptive therapy in patients with HIV/AIDS. METHOD : This was a ...
  • Deep sequencing of the HIV‑1 polymerase gene for characterisation of cytotoxic T‑lymphocyte epitopes during early and chronic disease stages 
    Nkone, Paballo; Loubser, Shayne; Quinn, Thomas C.; Redd, Andrew D.; Ismail, Arshad; Tiemessen, Caroline T.; Mayaphi, Simnikiwe Horatious (BMC, 2022-03)
    BACKGROUND : Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (pol) gene is highly conserved and encodes cytotoxic T-lymphocyte (CTL) epitopes. The aim of the study was ...
  • Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa 
    Tegally, Houriiyah; Moir, Monika; Everatt, Josie; Giovanetti, Marta; Scheepers, Cathrine; Wilkinson, Eduan; Subramoney, Kathleen; Makatini, Zinhle; Moyo, Sikhulile; Amoako, Daniel G.; Baxter, Cheryl; Althaus, Christian L.; Anyaneji, Ugochukwu J.; Kekana, Dikeledi; Viana, Raquel; Giandhari, Jennifer; Lessells, Richard; Maponga, Tongai; Maruapula, Dorcas; Choga, Wonderful; Matshaba, Mogomotsi; Mbulawa, Mpaphi B.; Msomi, Nokukhanya; NGS-SA consortium; Naidoo, Yeshnee; Pillay, Sureshnee; Sanko, Tomasz Janusz; San, James E.; Scott, Lesley; Singh, Lavanya; Magini, Nonkululeko A.; Smith-Lawrence, Pamela; Stevens, Wendy; Dor, Graeme; Tshiabuila, Derek; Wolter, Nicole; Preiser, Wolfgang; Treurnicht, Florette K.; Venter, Marietjie; Chiloane, Georginah; McIntyre, Caitlyn; O’Toole, Aine; Ruis, Christopher; Peacock, Thomas P.; Roemer, Cornelius; Pond, Sergei L. Kosakovsky; Williamson, Carolyn; Pybus, Oliver G.; Bhiman, Jinal N.; Glass, Allison; Martin, Darren P.; Jackson, Ben; Rambaut, Andrew; Laguda-Akingba, Oluwakemi; Gaseitsiwe, Simani; Von Gottberg, Anne; De Oliveira, Tulio; Bester, Armand Phillip; Claassen, Mathilda; Doolabh, Deelan; Mudau, Innocent; Mbhele, Nokuzola; Engelbrecht, Susan; Goedhals, Dominique; Hardie, Diana; Hsiao, Nei-Yuan; Iranzadeh, Arash; Ismail, Arshad; Joseph, Rageema; Maharaj, Arisha; Mahlangu, Boitshoko; Mahlakwane, Kamela; Davis, Ashlyn; Marais, Gert; Mlisana, Koleka; Mnguni, Anele; Mohale, Thabo; Motsatsi, Gerald; Mwangi, Peter; Ntuli, Noxolo; Nyaga, Martin; Olubayo, Luicer; Radibe, Botshelo; Ramphal, Yajna; Ramphal, Upasana; Strasheim, Wilhelmina; Tebeila, Naume; Van Wyk, Stephanie; Wilson, Shannon; Lucaci, Alexander G.; Weaver, Steven; Maharaj, Akhil; Pillay, Yusasha; Davids, Michaela; Mendes, Adriano; Mayaphi, Simnikiwe (Nature Research, 2022-09)
    Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa’s fourth Coronavirus Disease 2019 (COVID-19) wave. We ...
  • Evaluation of the Determine™ fourth generation HIV rapid assay 
    Brauer, Marieke; De Villiers, J.C. (Johanna Corrie); Mayaphi, Simnikiwe Horatious (Elsevier, 2013-04)
    Assays that detect p24 antigen reduce the diagnostic window period of HIV testing. Most point-of-care HIV assays have poor sensitivity to diagnose acute HIV infection as they only detect antibodies against HIV-1 and HIV-2 ...
  • Evaluation of the HIV-1 polymerase gene sequence diversity for prediction of recent HIV-1 infections using Shannon entropy analysis 
    Nkone, Paballo; Loubser, Shayne; Quinn, Thomas C.; Redd, Andrew D.; Laeyendecker, Oliver; Tiemessen, Caroline T.; Mayaphi, Simnikiwe Horatious (MDPI, 2022-07-21)
    HIV-1 incidence is an important parameter for assessing the impact of HIV-1 interventions. The aim of this study was to evaluate HIV-1 polymerase (pol) gene sequence diversity for the prediction of recent HIV-1 infections. ...
  • Field performance of the INSTI HIV‐1/‐2 antibody test in two South African antenatal clinics 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Quinn, Thomas C.; Stoltz, Anton Carel (Wiley, 2019-07)
    This was a prospective study that assessed field performance of the INSTI HIV‐1/‐2 antibody test (INSTI test) in two antenatal clinics in South Africa (SA). INSTI test was evaluated against rapid tests used at these clinics, ...
  • Hand-foot-and-mouth disease caused by coxsackievirus A6 in a patient infected with HIV 
    Mayaphi, Simnikiwe Horatious; Van Zyl, Walda B.; Sono, Tinah; Loots, Donovan P.; Taylor, Maureen B. (MedPharm Publications, 2015)
    Hand, foot and mouth disease (HFMD) is common in children ≤ 5 years of age, and is mainly caused by enterovirus 71 and coxsackievirus A16 (CVA6). A 12-year-old boy on treatment for human immunodeficiency virus (HIV) ...
  • HBV/HIV co-infection : the dynamics of HBV in South African patients with AIDS 
    Mayaphi, Simnikiwe Horatious; Rossouw, Theresa M.; Masemola, Difuro P.; Olorunju, Steve A.S.; Mphahlele, M. Jeffrey; Martin, Desmond J. (Health and Medical Publishing Group, 2012-03)
    OBJECTIVE: As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, and their co-infection requires special management, we aimed to assess the serological and ...
  • Hepatitis B virus infection in post-vaccination South Africa : occult HBV infection and circulating surface gene variants 
    Amponsah-Dacosta, Edina; Lebelo, Ramokone L.; Rakgole, J. Nare; Selabe, Selokela G.; Gededzha, Maemu P.; Mayaphi, Simnikiwe Horatious; Powell, Eleanor A.; Blackard, Jason T.; Mphahlele, M. Jeffrey (Elsevier, 2015-02)
    No abstract available
  • High risk exposure to HIV among sexually active individuals who tested negative on rapid HIV tests in the Tshwane District of South Africa—the importance of behavioural prevention measures 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Olorunju, Steve A.S.; Williams, Brian G.; Quinn, Thomas C.; Stoltz, Anton Carel (Public Library of Science, 2018-02-02)
    OBJECTIVE : To assess the prevalence of HIV risk behaviour among sexually active HIV sero-negative individuals in the Tshwane district of South Africa (SA). METHODS : Demographic and HIV risk behaviour data were collected ...
  • Low seroprevalence of hepatitis E virus in pregnant women in an urban area near Pretoria, South Africa 
    Simani, Omphile E.; Seipone, Tshegofatso P.; Selabe, Gloria; Seheri, L. Mapaseka; Mphahlele, M.; Mayaphi, Simnikiwe Horatious; Steele, A. Duncan (Elsevier, 2022-03)
    OBJECTIVES : Hepatitis E virus (HEV) infection is a globally neglected health problem with a high burden in resource-poor communities. Pregnant women are at increased risk of complications. This pilot study sought to assess ...
  • Nosocomial outbreak of hepatitis B virus infection in a pediatric hematology and oncology unit in South Africa : epidemiological investigation and measures to prevent further transmission 
    Buchner, Ane; Du Plessis, Nicolette Marie; Reynders, David; Omar, Fareed E.; Mayaphi, Simnikiwe Horatious; Haeri Mazanderani, Ahmad F.; Avenant, Theunis Johannes (Wiley, 2015-11)
    BACKGROUND : Hospital-acquired hepatitis B virus (HBV) infection has been well described and continues to occur worldwide. Recent nosocomial outbreaks have been linked to unsafe injection practices, use of multi-dose vials, ...
  • Pre-treatment minority HIV-1 drug resistance mutations and long term virological outcomes : is prediction possible? 
    Mzingwane, Mayibongwe L.; Tiemessen, C.T.; Richter, Karin Louise; Mayaphi, Simnikiwe Horatious; Hunt, G.; Bowyer, S.M. (BioMed Central, 2016-10-12)
    BACKGROUND : Although the use of highly active antiretroviral therapy in HIV positive individuals has proved to be effective in suppressing the virus to below detection limits of commonly used assays, virological failure ...
  • Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa 
    Viana, Raquel; Moyo, Sikhulile; Amoako, Daniel G.; Tegally, Houriiyah; Scheepers, Cathrine; Althaus, Christian L.; Anyaneji, Ugochukwu J.; Bester, Phillip A.; Boni, Maciej F.; Chand, Mohammed; Choga, Wonderful T.; Colquhoun, Rachel; Davids, Michaela; Deforche, Koen; Doolabh, Deelan; Du Plessis, Louis; Engelbrecht, Susan; Everatt, Josie; Giandhari, Jennifer; Giovanetti, Marta; Hardie, Diana; Hill, Verity; Hsiao, Nei-Yuan; Iranzadeh, Arash; Ismail, Arshad; Joseph, Charity; Joseph, Rageema; Koopile, Legodile; Pond, Sergei L. Kosakovsky; Kraemer, Moritz U.G.; Kuate-Lere, Lesego; Laguda-Akingba, Oluwakemi; Lesetedi-Mafoko, Onalethatha; Lessells, Richard; Lockman, Shahin; Lucaci, Alexander G.; Maharaj, Arisha; Mahlangu, Boitshoko; Maponga, Tongai; Mahlakwane, Kamela; Makatini, Zinhle; Marais, Gert; Maruapula, Dorcas; Masupu, Kereng; Matshaba, Mogomotsi; Mayaphi, Simnikiwe; Mbhele, Nokuzola; Mbulawa, Mpaphi B.; Mendes, Adriano; Mlisana, Koleka; Mnguni, Anele; Mohale, Thabo; Moir, Monika; Moruisi, Kgomotso; Mosepele, Mosepele; Motsatsi, Gerald; Motswaledi, Modisa S.; Mphoyakgosi, Thongbotho; Msomi, Nokukhanya; Mwangi, Peter N.; Naidoo, Yeshnee; Ntuli, Noxolo; Nyaga, Martin; Olubayo, Lucier; Pillay, Sureshnee; Radibe, Botshelo; Ramphal, Yajna; Ramphal, Upasana; San, James E.; Scott, Lesley; Shapiro, Roger; Smith-Lawrence, Pamela; Stevens, Wendy; Strydom, Amy; Subramoney, Kathleen; Tebeila, Naume; Tshiabuila, Derek; Tsui, Joseph; Van Wyk, Stephanie; Weaver, Steven; Wibmer, Constantinos K.; Wilkinson, Eduan; Wolter, Nicole; Zarebski, Alexander E.; Zuze, Boitumelo; Goedhals, Dominique; Preise, Wolfgang; Treurnicht, Florette; Venter, Marietjie; Williamson, Carolyn; Pybus, Oliver G.; Bhiman, Jinal; Glass, Allison; Martin, Darren P.; Rambaut, Andrew; Gaseitsiwe, Simani; Von Gottberg, Anne; De Oliveira, Tulio (Nature Research, 2022-03-24)
    The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) ...
  • Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV 
    Mayaphi, Simnikiwe Horatious; Martin, Desmond J.; Mphahlele, M. Jeffrey; Blackard, Jason T.; Bowyer, Sheila Mary (Wiley, 2013-11)
    Hepatitis B virus (HBV) is a serious global health problem, and HBV genotype is an important determinant of disease progression and treatment outcome. The aim of this study was to assess variations of the precore/core ...