dc.contributor.author |
Nguyen, Thi Kim Anh
|
|
dc.contributor.author |
Koets, Ad P.
|
|
dc.contributor.author |
Santema, Wiebren J.
|
|
dc.contributor.author |
Van Eden, Willem
|
|
dc.contributor.author |
Rutten, Victor P.M.G.
|
|
dc.contributor.author |
Van Rhijn, Ildiko
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dc.date.accessioned |
2009-09-04T09:48:24Z |
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dc.date.available |
2009-09-04T09:48:24Z |
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dc.date.issued |
2009 |
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dc.description.abstract |
Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole
limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that nonoverlapping
T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates. |
en |
dc.identifier.citation |
Nguyen TKA, et al. The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle. Vaccine (2009), doi:10.1016/j.vaccine.2009.05.078 |
en |
dc.identifier.issn |
0264-410X |
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dc.identifier.other |
10.1016/j.vaccine.2009.05.078 |
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dc.identifier.uri |
http://hdl.handle.net/2263/11171 |
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dc.language.iso |
en |
en |
dc.publisher |
Elsevier |
en |
dc.relation.requires |
Adobe Acrobat Reader |
en |
dc.rights |
Elsevier |
en |
dc.subject |
Mycobacterial glucose monomycolate |
en |
dc.subject |
Keyhole limpet haemocyanin |
en |
dc.subject.lcsh |
Cattle -- Vaccination |
en |
dc.subject.lcsh |
T cells |
en |
dc.subject.lcsh |
Glycolipids |
en |
dc.title |
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle |
en |
dc.type |
Postprint Article |
en |