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Browsing Research Articles (Pharmacology) by UP Author "Steenkamp, Vanessa"
Now showing items 1-20 of 60
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Lepule, Keagile Hilda; Cordier, Werner; Steenkamp, Paul; Nell, Margo Judith; Steenkamp, Vanessa (Elsevier, 2019-11)Parkinson’s disease, characterised by loss of dopaminergic neurons in the substantia nigra of the brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure is available, and dopamine-replacement ...
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Gulumian, Mary; Yahaya, Ewura Seidu; Steenkamp, Vanessa (Hindawi, 2018-11-22)The use of traditional herbal remedies as alternativemedicine plays an important role in Africa since it forms part of primary health care for treatment of various medical conditions, including wounds. Although physiological ...
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Steenkamp, Vanessa; Fernandes, Anthony C.; Jansen van Rensburg, Connie E. (Elsevier, 2007-12)Please refer to abstract in article
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Adewusi, Emmanuel Adekanmi; Moodley, N.; Steenkamp, Vanessa (Elsevier, 2011)Alzheimer's disease (AD) is the most common type of dementia in the aging population. Enhancement of acetylcholine levels in the brain is one means of treating the disease. However, the drugs presently used in the management ...
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Mohamed, Khaled M.; Steenkamp, Vanessa (Wiley, 2016-12)Cases of poisoning by p-phenylenediamine (PPD) are detected sporadically. Recently an article on the development and validation of a LC-MS/MS method for the detection of PPD and its metabolites, N-acetyl-p-phenylenediamine ...
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Yahaya, Ewura Seidu; Cordier, Werner; Steenkamp, Paul Anton; Steenkamp, Vanessa (Wiley, 2018-01)OBJECTIVES : Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential ...
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Cordier, Werner; Gulumian, Mary; Cromarty, Allan Duncan; Steenkamp, Vanessa (BioMed Central, 2013-05-28)BACKGROUND: Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants. Exogenous supplementation with antioxidants could result in ...
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Sakr, Samar; Hassanien, Hanan; Bester, Megan Jean; Arbi, Sandra; Sobhy, Azza; El Negris, Heba; Steenkamp, Vanessa (Royal Society of Chemistry, 2018-03)The aim of this study was to evaluate the protective effect of folate against methomyl-induced toxicity on the kidneys and testes of male rats. Adult male albino rats were divided into four groups; Group I served as the ...
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Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
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De Vries, Konrad; Strydom, Morne A.; Steenkamp, Vanessa (Elsevier, 2018-03)Resveratrol is a naturally occurring polyphenol that has been shown to elicit a variety of beneficial effects in vitro. Translating these gains to in vivo and clinical settings has proven to be a major challenge, because ...
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De Vries, Konrad; Strydom, Morne A.; Steenkamp, Vanessa (MDPI, 2021-07-20)Resveratrol (RES) has a low bioavailability. This limitation was addressed in an earlier review and several recommendations were offered. A literature search was conducted in order to determine the extent of the research ...
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Cordier, Werner; Steenkamp, Vanessa (Elsevier, 2018-01)INTRODUCTION : Traditional remedies remain a prominent form of therapy in developing countries, such as South Africa. Boophone disticha, or the poison bulb, is used for the treatments of wounds. There is generally a lack ...
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Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
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Schroeder, Ilka Elizma; Van Tonder, Jacob John; Steenkamp, Vanessa (Bentham Science, 2012)The organochlorine compound, pentachlorophenol (PCP), is classified as a hazardous substance. Its metabolite, tetrachloro-1,2-hydroquinone (TCHQ), has been detected in occupationally-exposed subjects and can readily be ...
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Marais, Andre; Steenkamp, Vanessa; Du Plooy, Wim J. (Medpharm Publications, 2017)BACKGROUND : Herbal medications are used worldwide for a variety of diseases and conditions. Patients often elect not to disclose their herbal use history, or health care practitioners fail to enquire about specific ...
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Marais, Andre; Steenkamp, Vanessa; Du Plooy, Wim J. (Medpharm Publications, NISC (Pty) Ltd and Cogent, Taylor & Francis Group, 2015-01)BACKGROUND : Herbal medications are used worldwide for a variety of diseases and conditions. Patients often elect not to disclose their herbal use history, or health care practitioners fail to enquire about specific ...
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Fraser, Desiree Linda; Stander, Barend Andre; Steenkamp, Vanessa (Elsevier, 2019-08)As knowledge regarding mechanisms of pentachlorophenol (PCP) toxicity in neuronal cell lines is limited, the aim of the study was to evaluate the effects of PCP and its active metabolites, tetrachloro-1,4-benzoquinone ...
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Adewusi, Emmanuel Adekanmi; Fouche, Gerda; Steenkamp, Vanessa (Elsevier, 2012-09-28)ETHNOPHARMACOLOGICAL RELEVANCE: Boophane disticha of the family Amaryllidaceae is used traditionally in southern Africa in the treatement of several neurological disorders. AIM OF THE STUDY: Although acetylcholinesterase ...
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Mohamed, Khaled M.; Cromarty, Allan Duncan; Steenkamp, Vanessa (Elsevier, 2015-08)In some developing countries, p-phenylenediamine (PPD) is used in combination with Henna as hair dye or skin decoration. A sensitive LC–MS/MS method was developed and validated for the simultaneous determination of ...
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Liebenberg, Jade; Du Toit-Prinsloo, Lorraine; Saayman, Gert; Steenkamp, Vanessa (Institute for Security Studies, 2019-03)Driving under the influence is a major threat to road safety in South Africa. Various psychoactive substances (both licit and illicit) have the potential to adversely affect driving performance and increase the probability ...
Now showing items 1-20 of 60