Browsing Bioinformatics and Computational Biology Unit by Issue Date

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Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase

Burger, Pieter Buys; Birkholtz, Lyn-Marie; Joubert, Fourie; Haider, Nashya; Walter, Rolf D.; Louw, Abraham Izak (Elsevier, 2007-02)

Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic translation initiation factor ...
The SeqWord Genome Browser : an online tool for the identification and visualization of atypical regions of bacterial genomes through oligonucleotide usage

Ganesan, Hamilton; Rakitianskaia, Anna S.; Davenport, Colin F.; Tummler, Burkhard; Reva, Oleg N. (BioMed Central, 2008-08)

BACKGROUND: Data mining in large DNA sequences is a major challenge in microbial genomics and bioinformatics. Oligonucleotide usage (OU) patterns provide a wealth of information for large scale sequence analysis and ...
TULIP software and web server : automatic classification of protein sequences based on pairwise comparisons and Z-value statistics

Grando, Delphine; Ortet, Philippe; Joubert, Fourie; Marechal, Eric; Bastien, Olivier (Bentham Science, 2009-03)

A configuration space of homologous protein sequences (or CSHP) has been recently constructed based on pairwise comparisons, with probabilities deduced from Z-value statistics (Monte Carlo methods applied to pairwise ...

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