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dc.contributor.author | Meiring, Susan![]() |
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dc.contributor.author | Cohen, Cheryl![]() |
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dc.contributor.author | De Gouveia, Linda![]() |
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dc.contributor.author | Du Plessis, Mignon![]() |
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dc.contributor.author | Quan, Vanessa![]() |
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dc.contributor.author | Kleynhans, Jackie![]() |
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dc.contributor.author | Menezes, Colin![]() |
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dc.contributor.author | Reubenson, Gary![]() |
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dc.contributor.author | Dawood, Halima![]() |
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dc.contributor.author | Nchabeleng, Maphoshane![]() |
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dc.contributor.author | Said, Mohamed![]() |
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dc.contributor.author | Mvelase, Nomonde![]() |
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dc.contributor.author | Mahabeer, Prasha![]() |
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dc.contributor.author | Chomba, Rispah![]() |
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dc.contributor.author | Lekalakala, Ruth![]() |
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dc.contributor.author | Nana, Trusha![]() |
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dc.contributor.author | Chibabhai, Vindana![]() |
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dc.contributor.author | Black, Marianne![]() |
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dc.contributor.author | Von Gottberg, Anne![]() |
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dc.date.accessioned | 2023-05-10T11:37:53Z | |
dc.date.available | 2023-05-10T11:37:53Z | |
dc.date.issued | 2022-09 | |
dc.description.abstract | OBJECTIVES : Providing country-specific estimates of case fatality and sequelae from bacterial meningitis (BM) is important to evaluate and monitor progress toward the World Health Organization's roadmap to “defeating meningitis by 2030”. METHODS : From 2016-2020, GERMS-SA conducted enhanced surveillance at 26 hospitals across South Africa. Episodes of laboratory-confirmed BM due to Streptococcus pneumoniae, Haemophilus influenzae , and Neisseria meningitidis were included. Risk factors for in-hospital death and sequelae at hospital discharge among survivors were analyzed. RESULTS : Of 12,717 invasive bacterial infections reported nationally, 39% (4980) were from enhanced surveillance sites, including 4159 pneumococcal, 640 H. influenzae , and 181 meningococcal infections. BM accounted for 32% (1319/4159) of pneumococcal, 21% (136/640) of H. influenzae , and 83% (151/181) of meningococcal invasive diseases. Clinical data were available for 91% (1455/1606) of BM: 26% (376/1455) were aged <5 years, 50% (726/1455) were female, and 62% (723/1171) with known HIV results, were HIV-infected. In-hospital case fatality was 37% (534/1455), and 24% (222/921) of survivors had adverse sequelae. Risk factors for death included altered mental status, HIV infection, and comorbidities. Risk factors for adverse sequelae included altered mental status and antimicrobial nonsusceptibility. CONCLUSION : BM in South Africa has a high case fatality, and adverse sequelae frequently occur among survivors. Those with comorbidities (including HIV) are at the highest risk. | en_US |
dc.description.department | Medical Microbiology | en_US |
dc.description.librarian | hj2023 | en_US |
dc.description.sponsorship | The NICD of the National Health Laboratory Service. | en_US |
dc.description.uri | http://www.elsevier.com/locate/ijid | en_US |
dc.identifier.citation | Meiring, S., Cohen, C., De Gouveia, L. et al. 2022, 'Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020', International Journal of Infectious Diseases, vol. 122, pp. 1056-1066. https://doi.org/10.1016/j.ijid.2022.07.068. | en_US |
dc.identifier.issn | 1201-9712 (print) | |
dc.identifier.issn | 1878-3511 (online) | |
dc.identifier.other | 10.1016/j.ijid.2022.07.068 | |
dc.identifier.uri | http://hdl.handle.net/2263/90612 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.subject | Meningitis | en_US |
dc.subject | Mortality | en_US |
dc.subject | Complications | en_US |
dc.subject | Streptococcus pneumoniae | en_US |
dc.subject | Haemophilus influenzae | en_US |
dc.subject | Neisseria meningitidis | en_US |
dc.title | Case-fatality and sequelae following acute bacterial meningitis in South Africa, 2016 through 2020 | en_US |
dc.type | Article | en_US |