dc.contributor.author |
Ameh, Veronica Odinya
|
|
dc.contributor.author |
Wu, Guanghui
|
|
dc.contributor.author |
Goharriz, Hooman
|
|
dc.contributor.author |
Shipley, Rebecca
|
|
dc.contributor.author |
Fook, Anthony R.
|
|
dc.contributor.author |
Sabeta, Claude Taurai
|
|
dc.contributor.author |
McElhinney, Lorraine M.
|
|
dc.date.accessioned |
2022-09-07T11:37:58Z |
|
dc.date.available |
2022-09-07T11:37:58Z |
|
dc.date.issued |
2021-11-27 |
|
dc.description.abstract |
Lagos bat lyssavirus (LBV) comprising four lineages (A, B, C and D) can potentially
cause the fatal disease rabies. Although LBV-B was initially isolated in Nigeria in 1956, there is no
information on LBV lineages circulating in Nigeria. This study was undertaken for the first time to
measure the neutralizing antibodies against four lineages of LBVs in straw-colored fruit bats (Eidolon
helvum) in Makurdi, Nigeria. Serum samples (n = 180) collected during two periods (November
2017–March 2018 and November 2018–March 2019) from terminally bled bats captured for human
consumption were tested using a modified fluorescent antibody virus neutralization (mFAVN) assay.
A high proportion of bat sera (74%) neutralized at least one lineage of LBV (with reciprocal titers from
9 to >420.89) and most of them neutralized LBV-A (63%), followed by LBV-D (49%), LBV-C (45%)
and LBV-B (24%). The majority of positive sera (75%, n = 100) neutralized multiple LBV lineages
while the remaining 25% (n = 33) neutralized only a single lineage, i.e., LBV-A (n = 23), LBV-D (n = 8)
and LBV-C (n = 2). None exclusively neutralized LBV-B. The results suggest that exposure to LBV
is common in E. helvum and that LBV-A (but not LBV-B) is likely to be circulating in this region of
Nigeria. |
en_US |
dc.description.department |
Veterinary Tropical Diseases |
en_US |
dc.description.librarian |
dm2022 |
en_US |
dc.description.sponsorship |
The UK Department for Environment, Food and Rural Affairs (Defra), the Scottish Government and the Welsh Government, the European Union’s Horizon 2020 research and innovation program and University of Pretoria Doctoral Research Bursary. |
en_US |
dc.description.uri |
https://www.mdpi.com/journal/viruses |
en_US |
dc.identifier.citation |
Ameh, V.O.; Wu, G.;
Goharriz, H.; Shipley, R.; Fooks, A.R.;
Sabeta, C.T.; McElhinney, L.M. Serum
Neutralization Profiles of StrawColored Fruit Bats (Eidolon helvum) in
Makurdi (Nigeria), against Four
Lineages of Lagos Bat Lyssavirus.
Viruses 2021, 13, 2378. https://doi.org/10.3390/v13122378. |
en_US |
dc.identifier.issn |
1999-4915 (online) |
|
dc.identifier.other |
10.3390/v13122378 |
|
dc.identifier.uri |
https://repository.up.ac.za/handle/2263/87109 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
MDPI |
en_US |
dc.rights |
: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/). |
en_US |
dc.subject |
Bats |
en_US |
dc.subject |
Lyssavirus |
en_US |
dc.subject |
Eidolon helvum |
en_US |
dc.subject |
Serology |
en_US |
dc.subject |
Lagos bat lyssavirus (LBV) |
en_US |
dc.subject |
Nigeria |
en_US |
dc.subject |
Straw-colored fruit bats (Eidolon helvum) |
en_US |
dc.title |
Serum neutralization profiles of straw-colored fruit bats (Eidolon helvum) in Makurdi (Nigeria), against four lineages of Lagos bat lyssavirus |
en_US |
dc.type |
Article |
en_US |