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dc.contributor.author | Ragheb, Suzan Mohammed![]() |
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dc.contributor.author | Govinden, Usha![]() |
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dc.contributor.author | Osei Sekyere, John![]() |
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dc.date.accessioned | 2022-08-16T11:11:12Z | |
dc.date.issued | 2022-03 | |
dc.description | SUPPLEMENTARY MATERIAL : Appendix S1. The role of MGEs in antimicrobial resistance (A) and the clonality (MLST) of isolates hosting resistance genes (B). | en_US |
dc.description | Dataset S1. Raw data of the information extracted from included articles and statistical analysis. | en_US |
dc.description | Figure S1. A PRISMA diagram showing the literature search strategy, inclusion and exclusion criteria, and the final number of included articles. | en_US |
dc.description | Table S1. (A–E) The sequence types of species harboring carbapenemases in Africa. | en_US |
dc.description.abstract | Antimicrobial resistance (AMR) is a public health threat globally. Carbapenems are β-lactam antibiotics used as last-resort agents for treating antibiotic-resistant infections. Mobile genetic elements (MGEs) play an important role in the dissemination and expression of antimicrobial resistance genes (ARGs), including the mobilization of ARGs within and between species. The presence of MGEs around carbapenem-hydrolyzing enzymes, called carbapenemases, in bacterial isolates in Africa is concerning. The association between MGEs and carbapenemases is described herein. Specific plasmid replicons, integrons, transposons, and insertion sequences were found flanking specific and different carbapenemases across the same and different clones and species isolated from humans, animals, and the environment. Notably, similar genetic contexts have been reported in non-African countries, supporting the importance of MGEs in driving the intra- and interclonal and species transmission of carbapenemases in Africa and globally. Technical and budgetary limitations remain challenges for epidemiological analysis of carbapenemases in Africa, as studies undertaken with whole-genome sequencing remained relatively few. Characterization of MGEs in antibiotic-resistant infections can deepen our understanding of carbapenemase epidemiology and facilitate the control of AMR in Africa. Investment in genomic epidemiology will facilitate faster clinical interventions and containment of outbreaks. | en_US |
dc.description.department | Medical Microbiology | en_US |
dc.description.embargo | 2022-11-09 | |
dc.description.librarian | hj2022 | en_US |
dc.description.uri | https://nyaspubs.onlinelibrary.wiley.com/journal/17496632 | en_US |
dc.identifier.citation | Ragheb, S.M., Govinden, U. & Osei Sekyere, J. 2022, 'Genetic support of carbapenemases: a One Health systematic review and meta-analysis of current trends in Africa', Annals of the New York Academy of Sciences, vol. 1509, no. 1, pp. 50-73, doi : 10.1111/nyas.14703. | en_US |
dc.identifier.issn | 0077-8923 (print) | |
dc.identifier.issn | 1749-6632 (online) | |
dc.identifier.other | 10.1111/nyas.14703 | |
dc.identifier.uri | https://repository.up.ac.za/handle/2263/86801 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.rights | © 2021 New York Academy of Sciences. This is the pre-peer reviewed version of the following article : 'Genetic support of carbapenemases: a One Health systematic review and meta-analysis of current trends in Africa', Annals of the New York Academy of Sciences, vol. 1509, no. 1, pp. 50-73, 2022, doi : 10.1111/nyas.14703. The definite version is available at : https://nyaspubs.onlinelibrary.wiley.co m/journal/17496632. | en_US |
dc.subject | Antimicrobial resistance (AMR) | en_US |
dc.subject | Mobile genetic elements (MGEs) | en_US |
dc.subject | Antimicrobial resistance genes (ARGs) | en_US |
dc.subject | Carbapenemase | en_US |
dc.subject | Africa | en_US |
dc.subject | Horizontal gene transfer | en_US |
dc.subject | One Health | en_US |
dc.title | Genetic support of carbapenemases : a One Health systematic review and meta-analysis of current trends in Africa | en_US |
dc.type | Postprint Article | en_US |