Tick-borne pathogens, including Crimean-Congo haemorrhagic fever virus, at livestock markets and slaughterhouses in western Kenya

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dc.contributor.author Chiuya, Tatenda
dc.contributor.author Masiga, Daniel K.
dc.contributor.author Falzon, Laura C.
dc.contributor.author Bastos, Armanda D.S.
dc.contributor.author Fevre, Eric M.
dc.contributor.author Villinger, Jandouwe
dc.date.accessioned 2021-09-28T08:23:03Z
dc.date.available 2021-09-28T08:23:03Z
dc.date.issued 2021-07
dc.description.abstract Vectors of emerging infectious diseases have expanded their distributional ranges in recent decades due to increased global travel, trade connectivity and climate change. Transboundary range shifts, arising from the continuous movement of humans and livestock across borders, are of particular disease control concern. Several tick-borne diseases are known to circulate between eastern Uganda and the western counties of Kenya, with one fatal case of Crimean-Congo haemorrhagic fever (CCHF) reported in 2000 in western Kenya. Recent reports of CCHF in Uganda have highlighted the risk of cross-border disease translocation and the importance of establishing interepidemic, early warning systems to detect possible outbreaks. We therefore carried out surveillance of tick-borne zoonotic pathogens at livestock markets and slaughterhouses in three counties of western Kenya that neighbour Uganda. Ticks and other ectoparasites were collected from livestock and identified using morphological keys. The two most frequently sampled tick species were Rhipicephalus decoloratus (35%) and Amblyomma variegatum (30%); Ctenocephalides felis fleas and Haematopinus suis lice were also present. In total, 486 ticks, lice and fleas were screened for pathogen presence using established molecular workflows incorporating high-resolution melting analysis and identified through sequencing of PCR products. We detected CCHF virus in Rh. decoloratus and Rhipicephalus sp. cattle ticks, and 82 of 96 pools of Am. variegatum were positive for Rickettsia africae. Apicomplexan protozoa and bacteria of veterinary importance, such as Theileria parva, Babesia bigemina and Anaplasma marginale, were primarily detected in rhipicephaline ticks. Our findings show the presence of several pathogens of public health and veterinary importance in ticks from livestock at livestock markets and slaughterhouses in western Kenya. Confirmation of CCHF virus, a Nairovirus that causes haemorrhagic fever with a high case fatality rate in humans, highlights the risk of under-diagnosed zoonotic diseases and calls for continuous surveillance and the development of preventative measures. en_ZA
dc.description.department Zoology and Entomology en_ZA
dc.description.librarian am2021 en_ZA
dc.description.sponsorship Economic & Social Research Council; Natural Environment Research Council; Deutscher Akademischer Austauschdienst; European Union’s Integrated Biological Control Applied Research Program; Defence Science & Technology Laboratory; Direktion für Entwicklung und Zusammenarbeit; Medical Research Council; CGIAR Research Program on Agriculture for Nutrition and Health; CGIAR Fund Donors; Styrelsen för Internationellt Utvecklingssamarbete; Department for International Development; Biotechnology and Biological Sciences Research Council. en_ZA
dc.description.uri http://wileyonlinelibrary.com/journal/tbed en_ZA
dc.identifier.citation Chiuya T, Masiga DK, Falzon LC, Bastos ADS, Fèvre EM, Villinger J. Tick-borne pathogens, including Crimean-Congo haemorrhagic fever virus, at livestock markets and slaughterhouses in western Kenya. Transboundary and Emerging Diseases 2021;68:2429–2445. https://DOI.org/10.1111/tbed.13911. en_ZA
dc.identifier.issn 1865-1674 (print)
dc.identifier.issn 1865-1682 (online)
dc.identifier.other 10.1111/tbed.13911
dc.identifier.uri http://hdl.handle.net/2263/81969
dc.language.iso en en_ZA
dc.publisher Wiley en_ZA
dc.rights © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License en_ZA
dc.subject East Africa en_ZA
dc.subject Emerging infectious disease en_ZA
dc.subject Nairovirus en_ZA
dc.subject Rhipicephalus en_ZA
dc.subject Rickettsia en_ZA
dc.subject Zoonoses en_ZA
dc.subject Crimean-Congo haemorrhagic fever (CCHF) en_ZA
dc.title Tick-borne pathogens, including Crimean-Congo haemorrhagic fever virus, at livestock markets and slaughterhouses in western Kenya en_ZA
dc.type Article en_ZA


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