dc.contributor.author |
Miller, Michele A.
|
|
dc.contributor.author |
Buss, Peter Erik
|
|
dc.contributor.author |
Roos, Eduard O.
|
|
dc.contributor.author |
Hausler, Guy
|
|
dc.contributor.author |
Dippenaar, Anzaan
|
|
dc.contributor.author |
Mitchell, Emily P.
|
|
dc.contributor.author |
Van Schalkwyk, Louis
|
|
dc.contributor.author |
Robbe-Austerman, Suelee
|
|
dc.contributor.author |
Waters, W. Ray
|
|
dc.contributor.author |
Sikar-Gang, Alina
|
|
dc.contributor.author |
Lyashchenko, Konstantin P.
|
|
dc.contributor.author |
Parsons, Sven D.C.
|
|
dc.contributor.author |
Warren, Robin
|
|
dc.contributor.author |
Van Helden, Paul David
|
|
dc.date.accessioned |
2019-09-03T10:32:29Z |
|
dc.date.available |
2019-09-03T10:32:29Z |
|
dc.date.issued |
2019-02-06 |
|
dc.description.abstract |
Tuberculosis (TB) in humans is a global public health concern and the discovery of animal
cases of Mycobacterium tuberculosis (Mtb) infection and disease, especially in multi-host
settings, also has significant implications for public health, veterinary disease control,
and conservation endeavors. This paper describes a fatal case of Mtb disease in a
free-ranging African elephant (Loxodonta africana) in a high human TB burden region.
Necropsy revealed extensive granulomatous pneumonia, from which Mtb was isolated
and identified as a member of LAM3/F11 lineage; a common lineage found in humans
in South Africa. These findings are contextualized within a framework of emerging Mtb
disease in wildlife globally and highlights the importance of the One Health paradigm in
addressing this anthroponotic threat to wildlife and the zoonotic implications. |
en_ZA |
dc.description.department |
Veterinary Tropical Diseases |
en_ZA |
dc.description.librarian |
am2019 |
en_ZA |
dc.description.sponsorship |
The South African Medical Research
Council and National Research Foundation, including the South
African Research Chair Initiative (grant number 86949); and by
National Research Foundation core funding given to the National
Zoological Gardens. |
en_ZA |
dc.description.uri |
https://www.frontiersin.org/journals/veterinary-science# |
en_ZA |
dc.identifier.citation |
Miller MA, Buss P, Roos EO,
Hausler G, Dippenaar A, Mitchell E,
van Schalkwyk L,
Robbe-Austerman S, Waters WR,
Sikar-Gang A, Lyashchenko KP,
Parsons SDC, Warren R and van
Helden P (2019) Fatal Tuberculosis in
a Free-Ranging African Elephant and
One Health Implications of Human
Pathogens in Wildlife.
Frontiers in Veterinary Science 6:18.
DOI: 10.3389/fvets.2019.00018. |
en_ZA |
dc.identifier.issn |
2297-1769 (online) |
|
dc.identifier.other |
10.3389/fvets.2019.00018 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/71263 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Frontiers Media |
en_ZA |
dc.rights |
© 2019 Miller, Buss, Roos, Hausler, Dippenaar, Mitchell, van Schalkwyk,
Robbe-Austerman, Waters, Sikar-Gang, Lyashchenko, Parsons, Warren and van
Helden. This is an open-access article distributed under the terms of the Creative
Commons Attribution License (CC BY). |
en_ZA |
dc.subject |
Anthroponosis |
en_ZA |
dc.subject |
One health |
en_ZA |
dc.subject |
Wildlife disease |
en_ZA |
dc.subject |
African elephant (Loxodonta africana) |
en_ZA |
dc.subject |
Mycobacterium tuberculosis (MTB) |
en_ZA |
dc.subject |
Tuberculosis (TB) |
en_ZA |
dc.subject.other |
Veterinary science articles SDG-03 |
en_ZA |
dc.subject.other |
Veterinary science articles SDG-15 |
en_ZA |
dc.subject.other |
SDG-15: Life on land |
|
dc.subject.other |
SDG-03: Good health and well-being |
|
dc.title |
Fatal tuberculosis in a free-ranging African elephant and one health implications of human pathogens in wildlife |
en_ZA |
dc.type |
Article |
en_ZA |