dc.contributor.author |
Kharkova, Olga A.
|
|
dc.contributor.author |
Grjibovski, Andrej M.
|
|
dc.contributor.author |
Krettek, Alexandra
|
|
dc.contributor.author |
Nieboer, Evert
|
|
dc.contributor.author |
Odland, Jon Oyvind
|
|
dc.date.accessioned |
2018-07-19T12:27:54Z |
|
dc.date.available |
2018-07-19T12:27:54Z |
|
dc.date.issued |
2017-08-10 |
|
dc.description.abstract |
BACKGROUND : Although prior studies have shown that smoking reduces preeclampsia/eclampsia risk, the
consequence of giving up this habit during pregnancy should be assessed. The aims of the
current study were threefold: (i) describe maternal characteristics of women with preeclampsia/
eclampsia; (ii) examine a possible association between the number of cigarettes smoked
daily during pregnancy and the development of this affliction; and (iii) determine if first-trimester
discontinuation of smoking during pregnancy influences the risk.
METHODS : A registry-based study was conducted using data from the Murmansk County Birth Registry
(MCBR). It included women without pre-existing hypertension, who delivered a singleton
infant during 2006±2011 and had attended the first antenatal visit before 12 week of gestation.
We adjusted for potential confounders using logistic regression.
RESULTS : The prevalence of preeclampsia/eclampsia was 8.3% (95%CI: 8.0±8.6). Preeclampsia/
eclampsia associated with maternal age, education, marital status, parity, excessive weight
gain and body mass index at the first antenatal visit. There was a dose-response relationship
between the number of smoked cigarettes per day during pregnancy and the risk of preeclampsia/
eclampsia (adjusted OR1-5 cig/day = 0.69 with 95%CI: 0.56±0.87; OR6-10 cig/day = 0.65 with 95%CI: 0.51±0.82; and OR 11 cig/day = 0.49 with 95%CI: 0.30±0.81). There was no difference in this risk among women who smoked before and during pregnancy and those
who did so before but not during pregnancy (adjusted OR = 1.10 with 95%CI: 0.91±1.32).
CONCLUSIONS : Preeclampsia/eclampsia was associated with maternal age, education, marital status, parity,
excessive weight gain, and body mass index at the first antenatal visit. There was a negative
dose-response relationship between the number of smoked cigarettes per day during
pregnancy and the odds of preeclampsia/eclampsia. However, women who gave up smoking
during the first trimester of gestation had the same risk of preeclampsia/eclampsia as
those who smoked while pregnant. Consequently, antenatal clinic specialists are advised to
take these various observations into account when counselling women on smoking cessation
during pregnancy. |
en_ZA |
dc.description.department |
School of Health Systems and Public Health (SHSPH) |
en_ZA |
dc.description.librarian |
am2018 |
en_ZA |
dc.description.uri |
http://www.plosone.org |
en_ZA |
dc.identifier.citation |
Kharkova OA, Grjibovski AM, Krettek A,
Nieboer E, Odland JØ (2017) First-trimester
smoking cessation in pregnancy did not increase
the risk of preeclampsia/eclampsia: A Murmansk
County Birth Registry study. PLoS ONE 12(8):
e0179354. https://DOI.org/10.1371/journal.pone.0179354. |
en_ZA |
dc.identifier.issn |
1932-6203 (online) |
|
dc.identifier.other |
10.1371/journal.pone.0179354 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/65790 |
|
dc.language.iso |
en |
en_ZA |
dc.publisher |
Public Library of Science |
en_ZA |
dc.rights |
© 2017 Kharkova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. |
en_ZA |
dc.subject |
Smoking |
en_ZA |
dc.subject |
Preeclampsia/eclampsia risk |
en_ZA |
dc.subject |
Pregnancy |
en_ZA |
dc.subject |
Women |
en_ZA |
dc.title |
First-trimester smoking cessation in pregnancy did not increase the risk of preeclampsia/eclampsia : a Murmansk county birth registry study |
en_ZA |
dc.type |
Article |
en_ZA |