Neutrophil disorders are commonly encountered in clinical practice. However, these encompass a variety of
different conditions with variable presentation, making neutrophil disorders a diagnostic challenge to most
clinicians. These disorders can be better understood when approached by distinguishing between disorders
affecting mainly neutrophil numbers or function and by identifying which normal neutrophil processes are
affected. The choice of assays for investigation of neutrophil disorders depends on a variety of factors, for
example family history, clinical and laboratory findings.1–3 This article aims to provide an overview of the
clinical presentation and recommended diagnostic tests for the most important neutrophil disorders.