BACKGROUND. Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have
reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant ...
Hendriksz, Christian J.; Anheim, Mathieu; Bauer, Peter; Bonnot, Olivier; Chakrapani, Anupam; Corvol, Jean-Christophe; De Koning, Tomas J.; Degtyareva, Anna; Dionisi-Vici, Carlo; Doss, Sarah; Duning, Thomas; Giunti, Paola; Iodice, Rosa; Johnston, Tracy; Kelly, Dierdre; Klünemann, Hans-Hermann; Lorenzl, Stefan; Padovani, Alessandro; Pocovi, Miguel; Synofzik, Matthis; Terblanche, Alta; Then Bergh, Florian; Topçu, Meral; Tranchant, Christine; Walterfang, Mark; Velten, Christian E.; Kolb, Stefan A.(Taylor and Francis, 2017-03)
BACKGROUND : Niemann-Pick disease type C (NP-C) is a rare, inherited neurodegenerative disease of impaired intracellular lipid trafficking. Clinical symptoms are highly heterogeneous, including neurological, visceral, or ...
Lamb, Gregory V.; Van Niekerk, Andre; Green, Robin J.(Allergy Society of South Africa, 2017-09)
Caesarean sections, and especially elective Caesarean sections, are on the increase worldwide.
The grey-matter volume of the foetal brain undergoes a linear increase of 1,4% per week from 29 weeks
until 40 weeks of ...
Van Rooyen, Cathy; Van den Berg, Sylvia; Gouws, Wilmare; Green, Robin J.(Allergy Society of South Africa, 2017-09)
Neutrophil disorders are commonly encountered in clinical practice. However, these encompass a variety of
different conditions with variable presentation, making neutrophil disorders a diagnostic challenge to most
De Franco, Elisa; Flanagan, Sarah E.; Yagi, Takuya; Abreu, Damien; Mahadevan, Jana; Johnson, Matthew B.; Jones, Garan; Acosta, Fernanda; Mulaudzi, M.C. (Mphele); Lek, Ngee; Oh, Vera; Petz, Oliver; Caswell, Richard; Ellard, Sian; Urano, Fumihiko; Hattersley, Andrew T.(American Diabetes Association Inc., 2017-07)
Neonatal diabetes is frequently part of a complex syndrome with extra-pancreatic features: 18 genes causing syndromic neonatal diabetes have been identified to date. There remain patients with neonatal diabetes who have ...
Coetzee, Melantha; Mbowane, N.T. (Ndziponile); De Witt-Jordaan, T.W. (Wilma)(Health and Medical Publishing Group, 2017-06)
Neonatal sepsis is a clinical syndrome consisting of nonspecific symptoms and signs of infection, accompanied by a bacteraemia in the
first 28 days of life. The risk of neonatal sepsis and death increases with decreasing ...
McLoughlin, Mairead; Stepien, Karolina M.; McNelly, Briony; Thompson, Lorraine; Gorton, Janet; Hendriksz, Christian J.(Elsevier, 2017-12)
Port-a-cath is a widely used device in patients with long-term venous access demand such as frequent or continuous
administration of medications such as Enzyme Replacement Therapy (ERT), chemotherapy delivery,
Cerebral palsy (CP) cases are some of the primary
reasons for litigation of high quantum amounts
against obstetricians both in the public and private
sector, on the basis of acute intrapartum hypoxia
resulting in ...
Lamb, Gregory V.; Green, Robin J.(Allergy Society of South Africa, 2017-06)
The enteric nervous system and the central nervous system are no longer viewed as being separate entities.
They are connected to each other by the vagal nerve which allows for bi-directional communication between
Haus, Matthias(Allergy Society of South Africa, 2017-03)
The delivery of healthcare has, over the past 2 500 years, been firmly entrenched in the domain of the
physician. Since the ‘Father of Medicine’, Hippocrates (470 BC) created his vision for just, moral and ethical
BACKGROUND : In October 2012 Uganda extended its prevention of mother to child HIV transmission (PMTCT) policy
to Option B+, providing lifelong antiretroviral treatment for HIV positive pregnant and breastfeeding women. ...
Van den Berg, Sylvia; Van Rooyen, Cathy; Green, Robin J.(Allergy Society of South Africa, 2017-03)
Primary immunodeficiencies (PIDs) remain largely
undiagnosed and underreported in South Africa.1
PIDs are inherited, non-communicable disorders that
involve a defect in one or more components of the immune
Sherman, Gayle G.; Mazanderani, Ahmad Haeri; Barron, Peter; Bhardwaj, Sanjana; Niit, Ronelle; Okobi, Margaret; Puren, Adrian; Jackson, Debra J.; Goga, Ameena Ebrahim(Edinburgh University Global Health Society, 2017-06)
BACKGROUND : South Africa has utilized three independent
data sources to measure the impact of its program
for the prevention of mother–to–child transmission
(PMTCT) of HIV. These include the South African
De Vries, P.J.; Leclezio, L.; Wilmshurst, J.M.; Fieggen, G.; Gottlich, E.; Jacklin, L.; Naiker, I.P.; Newaj, R.; Shamley, D.; Schlegel, B.; Venter, A.(Health and Medical Publishing Group, 2017-05)
Tuberous sclerosis complex (TSC) is a genetic disorder with multi-system manifestations and a high burden of disease. In 2013, an
international panel of TSC experts revised the guidelines for the diagnosis, surveillance ...
OBJECTIVES Wealth-related inequality across the South
African antenatal HIV care cascade has not been
considered in detail as a potential hindrance to eliminating
mother-to-child HIV transmission (EMTCT). We aimed ...
Fatti, Geoffrey; Shaikh, Najma; Jackson, Debra; Goga, Ameena Ebrahim; Nachega, Jean B.; Eley, Brian; Grimwood, Ashraf(Public Library of Science, 2017-07-27)
BACKGROUND : Young Southern African women have the highest HIV incidence globally. Pregnancy doubles the risk of HIV acquisition further, and maternal HIV acquisition contributes significantly to the paediatric HIV burden. ...
Von Mollendorf, Claire; Tempia, Stefano; Von Gottberg, Anne; Meiring, Susan; Quan, Vanessa; Feldman, Charles; Cloete, Jeane; Madhi, Shabir A.; O'Brien, Katherine L.; Klugman, Keith P.; Whitney, Cynthia G.; Cohen, Cheryl(Public Library of Science, 2017-07-03)
INTRODUCTION : Streptococcus pneumoniae is a leading cause of severe bacterial infections globally. A full understanding of the impact of pneumococcal conjugate vaccine (PCV) on pneumococcal disease burden, following its ...
Goga, Ameena Ebrahim; Hamilton, Elizabeth; Bossiky, Bernard; Ditekemena, John; Esiru, Godfrey; Fwamba, Franck; Van de Ven, Roland; Wafula, Rose; Kieffer M.P.; Tsague, Landry D.; Van de Ven, Roland; Wafula, Rose; Guay, Laura(Lippincott Williams and Wilkins, 2017-05-01)
BACKGROUND : Development of country plans for prevention of mother-to-
child HIV transmission (PMTCT), including expansion of comprehensive,
integrated services, was key to Global Plan achievements.
APPROACHES : Use ...
Van Biljon, Gertruida; Karusseit, V.O.L. (Otto)(Wiley, 2017-08)
BACKGROUND : The South African Renal Registry (SARR) was re-established in 2010. The first report was produced in 2014. It revealed that only 3182 patients out of 43.6 million people who were dependent on the state for ...
BACKGROUND : A number of scientific organisations have developed guidelines for the primary prevention of allergic
disease through nutritional interventions. However, even if the best evidence-based guidelines are available, ...