Prevention of cervical cancer in HIV-seropositive women from developing countries : a systematic review protocol

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Authors

Mapanga, Witness
Elhakeem, Ahmed
Feresu, Shingairai A.
Maseko, Fresier
Chipato, Tsungai

Journal Title

Journal ISSN

Volume Title

Publisher

BioMed Central

Abstract

BACKGROUND : Over 85% of cervical cancer cases and deaths occur in developing countries. HIV-seropositive women are more likely to develop precancerous lesions that lead to cervical cancer than HIV-negative women. However, the literature on cervical cancer prevention in seropositive women in developing countries has not been reviewed. The aim of this study is to systematically review cervical cancer prevention modalities available for HIV-seropositive women in developing countries. METHODS/DESIGN : This protocol was developed by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and the systematic review will be reported in accordance with the PRISMA guidelines. Embase, MEDLINE, PubMed, CINAHL and Cochrane Library will be searched from inception up to date of final search, and additional studies will be located through citation and reference list tracking. Eligible studies will be randomised controlled trials, prospective and retrospective cohort studies, case-control and crosssectional studies carried out in developing countries. Studies will be included if they are published in English and examine cervical cancer prevention modalities in HIV-seropositive women. Results will be summarised in tables and, where appropriate, combined using meta-analysis. DISCUSSION : This review will address the gap in evidence by systematically reviewing the published literature on the different prevention modalities being used to prevent cervical cancer in HIV-seropositive women in developing countries. The findings may be used to inform evidence-based guidelines for prevention of cervical cancer in seropositive women as well as future research.

Description

Additional file 1: Full-text screening form. This form will be used for the screening of potentially eligible studies to be included in the review.
Additional file 2: Data extraction form. This form will be used to extract relevant data such as exposure and outcome and statistics from the included studies.
Additional file 3: Quality assessment form. This form will be used for grading the quality of studies included in the review. It is a modified/ amended version of the Newcastle-Ottawa Quality Assessment Scale.

Keywords

Developing countries, Cervical cancer, Human immunodeficiency virus (HIV), Vaccination, Uterine cervix cancer, Systematic review, Randomized controlled trial, Quality of life, Protocol compliance, Papanicolaou test, Outcome assessment, Follow-up, Female, Cancer prevention

Sustainable Development Goals

Citation

Mapanga W., Elhakeem A., Feresu S.A., Maseko F. & Chipato T. 2017, 'Prevention of cervical cancer in HIV-seropositive women from developing countries : a systematic review protocol', Systematic Reviews, vol. 6, art. no. 91, pp. 1-7.