dc.contributor.author |
Kell, Douglas B.
|
|
dc.contributor.author |
Pretorius, Etheresia
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|
dc.date.accessioned |
2016-07-04T09:31:40Z |
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dc.date.available |
2016-07-04T09:31:40Z |
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dc.date.issued |
2015 |
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dc.description.abstract |
In a recent article, Koperdanova and Cullis 1 rehearsed the various interpretations of raised serum ferritin levels. In fact the most interesting question 2 is why does ferritin appear in serum at all?
All modern network models of iron metabolism (e.g. 3-7) have iron being passed from the gut to peripheral cells via blood (serum) bound to transferrin, a well-established iron-transporting molecule that is present in serum at ca 0.6-3.3 g.L-1 8. By contrast, ferritin is an intracellular iron storage compound 3 5 7; its normal range for serum is at levels 10,000-100,000 times lower than that for transferrin, being from very small levels to up to 300 μg.L-1 in men and slightly lower in women 2. |
en_ZA |
dc.description.department |
Physiology |
en_ZA |
dc.description.librarian |
am2016 |
en_ZA |
dc.description.sponsorship |
We thank the Biotechnology and Biological Sciences Research Council (grant BB/L025752/1) as well as the National Research Foundation (NRF) of South Africa for supporting this collaboration. |
en_ZA |
dc.description.uri |
http://www.bmj.com/thebmj |
en_ZA |
dc.identifier.citation |
Pretorius, E & Kell, DB 2015, 'Why does serum contain ferritin?', BMJ, vol. 351, h3692, pp. 1-3. |
en_ZA |
dc.identifier.issn |
0959-8138 (print) |
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dc.identifier.issn |
1756-1833 (online) |
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dc.identifier.uri |
http://hdl.handle.net/2263/53616 |
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dc.language.iso |
en |
en_ZA |
dc.publisher |
BMJ Publishing Group |
en_ZA |
dc.rights |
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license. |
en_ZA |
dc.subject |
Ferritin |
en_ZA |
dc.subject |
Apoptosis |
en_ZA |
dc.subject |
Iron dysregulation |
en_ZA |
dc.subject |
Inflammation |
en_ZA |
dc.subject |
Chronic diseases |
en_ZA |
dc.subject |
Atopobiosis |
en_ZA |
dc.title |
Why does serum contain ferritin? |
en_ZA |
dc.type |
Article |
en_ZA |