Browsing Research Articles (Medical Oncology) by Subject "Combination of everolimus"

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Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1) : a phase 3, randomised, double-blind, multicentre trial

Hurvitz, Sara A.; Andre, Fabrice; Jiang, Zefei; Shao, Zhimin; Mano, Max S.; Neciosup, Silvia P.; Tseng, Ling-Min; Zhang, Qingyuan; Shen, Kunwei; Liu, Donggeng; Dreosti, Lydia M.; Burris, Howard A.; Toi, Masakazu; Buyse, Marc E.; Cabaribere, David; Lindsay, Mary-Ann; Rao, Shantha; Pacaud, Lida Bubuteishvili; Taran, Tetiana; Slamon, Dennis (Elsevier, 2015-07)

BACKGROUND : mTOR inhibition has been shown to reverse trastuzumab resistance from hyperactivated the PIK/AKT/mTOR pathway due to PTEN loss, by sensitizing PTEN-deficient tumors towards trastuzumab. The BOLERO-1 study ...

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