• Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 

  Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)

  Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
• Reports of plant-derived nanoparticles for prostate cancer therapy 

  Elbagory, Abdulrahman M.; Hull, Rodney; Meyer, Mervin; Dlamini, Zodwa (MDPI, 2023-05-03)

  Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of ...
• Immunomodulatory gene-splicing dysregulation in tumorigenesis : unmasking the complexity 

  Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Yasasve, Madhavan; Dlamini, Zodwa; Damane, Botle Precious (MDPI, 2023-08-10)

  Cancer is a global health concern with rising incidence, morbidity, and mortality. The interaction between the tumor and immune cells within the tumor microenvironment is facilitated by signaling pathways driven by ...
• Drug standardization through pharmacognostic approaches and estimation of anticancer potential of chamomile (Matricaria chamomilla L.) using prostate-cancer cell lines : an in-vitro study 

  Khan, Nida; Kalam, Mohd Afsahul; Alam, Mohd Tauseef; Ul Haq, Syed Anam; Showket, Wasia; Dar, Zahoor A.; Rafiq, Nida; Mushtaq, Waseem; Rafeeqi, Towseef Amin; Dar, Mohammad Yunis; Akbar, Seema; Butt, Tariq Ahmad; Gani, Riehana; Majeed, Uzma; Chaudhary, Anis Ahmad; Rudayni, Hassan Ahmed; Al-Zharani, Mohammed; Shilbayeh, Sireen Abdul Rahim; Binsaleh, Ammena Yahia; El-Sheikh, Azza A.K.; Dlamini, Zodwa; Wani, Shabir Hussain; Khan, Shahanavaj; Masoodi, Khalid Z. (Ivyspring International Publisher, 2023-02-05)

  Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. ...
• The SARS-COV-2 seroprevalence among oncology patients 

  Kgatle, Mankgopo; Das, Rajesh; Lawal, Ismaheel Opeyemi; Boshomane, Tebatso M.G.; Mokoala, Kgomotso M.G.; Gaspar, Cattleya; Mbokazi, Lydia; Nkambule, Nonhlanhla; Gow, Veronique; Ndlovu, Honest; Mzizi, Yonwaba; Chalwe, Joseph; Diphofa, Jeaneth; Mokobodi, Dinah; Gxekwa, Nobuhle; Zongo, Lusanda; Maphosa, Tinashe; Vorster, Mariza; Bassa, Sheynaz; Venkatesan, Amouda; Khanyile, Richard; Munga, Yunus; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-01-09)

  Patients with cancer are presumed to be vulnerable to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe clinical outcomes due to the immunocompromised state mediated ...
• Imaging PARP upregulation with [123 I]I-PARPi SPECT/CT in small cell neuroendocrine carcinoma 

  Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Mokoala, Kgomotso M.G.; Disenyane, Dineo; Nkambule, Nonhlahla; Bassa, Sheynaz; Mzizi, Yonwaba; Bida, Meshack; Sathekge, Mike Machaba (Society of Nuclear Medicine and Molecular Imaging, 2024-04)

  Please read abstract in the article.
• Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease 

  Alalwany, Roaa H.; Hawtrey, Tom; Morgan, Kevin; Morris, Jonathan C.; Donaldson, Lucy F.; Bates, David Owen Bates (Frontiers Media, 2023-06-27)

  Please read abstract in the article.
• Targeting stem cells in the colorectal cancer microenvironment to avert drug resistance in pursuit of novel oncotherapies 

  Damane, Botle Precious; Marima, Rahaba; Mulaudzi, Thanyani; Dlamini, Zodwa (Biolife Sas, 2023-09)

  Several studies have demonstrated the heightened prevalence of colorectal cancer (CRC) among young black men. Most of these men present with already metastasized CRC. Cancer stem cells (CSCs) play a pivotal role in CRC ...
• In silico bioinformatics analysis on the role of long non-coding RNAs as drivers and gatekeepers of androgen-independent prostate cancer using LNCaP and PC-3 cells 

  Mbeje, Mandisa; Kandhavelu, Jeyalakshmi; Penny, Clement; Kgoebane-Maseko, Minah; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2023-09-01)

  Prostate cancer (PCa) is the leading cancer in men globally. The association between PCa and long non-coding RNAs (lncRNAs) has been reported. Aberrantly expressed lncRNAs have been documented in each of the cancer ...
• Selenium nanoparticles : a comprehensive examination of synthesis techniques and their diverse applications in medical research and toxicology studies 

  Sampath, Shobana; Sunderam, Veena; Manjusha, M.; Dlamini, Zodwa; Lawrance, Ansel Vishal (MDPI, 2024-02)

  Selenium is a trace and necessary micronutrient for human, animal, and microbial health. Many researchers have recently been interested in selenium nanoparticles (SeNPs) due to their biocompatibility, bioavailability, and ...
• Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 

  Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)

  Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
• Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 

  Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)

  Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...
• Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 

  Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (MDPI, 2023-08-07)

  Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
• Multi-omics and management of follicular carcinoma of the thyroid 

  Luvhengo, Thifhelimbilu Emmanuel; Bombil, Ifongo; Mokhtari, Arian; Moeng, Maeyane Stephens; Demetriou, Demetra Danielle; Sanders, Claire; Dlamini, Zodwa (MDPI, 2023-04-19)

  Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid gland, accounting for up to 20% of all primary malignant tumors in iodine-replete areas. The diagnostic work-up, staging, risk stratification, ...
• Towards perioperative point-of-care viscoelastic testing 

  Wessels, Pieter Frederik (Medpharm Publications, 2023)

  No abstract available.
• The integrative bioinformatics approaches to predict the xanthohumol as anti-breast cancer molecule : targeting cancer cells signaling PI3K and AKT kinase pathway 

  Gupta, Kartikey Kumar; Sharma, Kamal Kant; Chandra, Harish; Panwar, Himalaya; Bhardwaj, Nitin; Altwaijry, Najla A.; Alsfouk, Aisha A.; Dlamini, Zodwa; Afzal, Obaid; Altamimi, Abdulmalik S.A.; Khan, Shahanavaj; Mishra, Abhay Prakash (Frontiers Media S.A., 2022-12)

  BACKGROUND : Breast cancer is the most common type of cancer in women, and vast research is being conducted throughout the world for the treatment of this malignancy by natural products using various computational approaches. ...
• Viral encoded miRNAs in tumorigenesis : theranostic opportunities in precision oncology 

  Hull, Rodney; Marima, Rahaba; Alaouna, Mohammed; Demetriou, Demetra Danielle; Reis, Rui Manuel; Molefi, Thulo; Dlamini, Zodwa (MDPI, 2022-07-18)

  About 15% of all human cancers have a viral etiology. Although progress has been made, understanding the viral oncogenesis and associated molecular mechanisms remain complex. The discovery of cellular miRNAs has led to ...
• Competing endogenous RNA (ceRNA) networks and splicing switches in cervical cancer : HPV oncogenesis, clinical significance and therapeutic opportunities 

  Basera, Afra; Hull, Rodney; Demetriou, Demetra Danielle; Bates, David Owen; Kaufmann, Andreas Martin; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2022-09-16)

  Cervical cancer (CC) is the primary cause of female cancer fatalities in low-middle-income countries (LMICs). Persistent infections from the human papillomavirus (HPV) can result in cervical cancer. However, numerous ...
• AI and precision oncology in clinical cancer genomics : from prevention to targeted cancer therapies-an outcomes based patient care 

  Dlamini, Zodwa; Skepu, Amanda; Kim, Namkug; Mkhabele, Mahlori; Khanyile, Richard; Molefi, Thulo; Mbatha, Sikhumbuzo; Setlai, Botle; Mulaudzi, Thanyani Victor; Mabongo, Mzubanzi; Bida, Nndweleni Meshack; Kgoebane-Maseko, Minah; Mathabe, Kgomotso; Lockhat, Zarina I.; Kgokolo, C.M.; Chauke-Malinga, Nkhensani; Ramagaga, Serwalo; Hull, Rodney (Elsevier, 2022)

  Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic ...
• Influence of the microbiome metagenomics and epigenomics on gastric cancer 

  Mathebela, Precious; Damane, Botle Precious; Mulaudzi, Thanyani Victor; Mkhize-Khwitshana, Zilungile Lynette; Gaudji, Guy Roger; Dlamini, Zodwa (MDPI, 2022-11)

  Gastric cancer (GC) is one of the major causes of cancer deaths worldwide. The disease is seldomly detected early and this limits treatment options. Because of its heterogeneous and complex nature, the disease remains ...

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