• Directions to overcome therapy resistance in cancer 

  Nussinov, Ruth; Weichhart, Thomas; Dlamini, Zodwa; Gibbons, Don L.; Van Seuningen, Isabelle; Konen, Jessica; Ju, Huai-Qiang (Elsevier, 2024-06)

  Novel modalities for treatment of cancer have emerged because of advances in technology that have enabled expansion of our understanding of how cells transform to become cancerous and the role of the tumor microenvironment ...
• Editorial : Molecular targets for anticancer drug discovery and development 

  Ntwasa, Monde; Dlamini, Zodwa (Frontiers Media, 2024-04)

  No abstract available.
• Editorial : The RNA revolution and cancer 

  Dlamini, Zodwa; Ladomery, Michael R.; Kahraman, Abdullah (Frontiers Media, 2024-05)

  RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor ...
• Exploring water-soluble South African Tulbaghia violacea Harv extract as a therapeutic approach for triple-negative breast cancer metastasis 

  Alaouna, Mohammed; Hull, Rodney; Molefi, Thulo; Khanyile, Richard; Mbodi, Langanani; Luvhengo, Thifhelimbilu Emmanuel; Chauke-Malinga, Nkhensani; Phakathi, Boitumelo P.; Penny, Clement; Dlamini, Zodwa (MDPI, 2024-10)

  Triple-negative breast cancer (TNBC) accounts for approximately 20% of all breast cancer cases and is characterized by a lack of estrogen, progesterone, and human epidermal growth factor 2 receptors. Current targeted ...
• The convergence of radiology and genomics : advancing breast cancer diagnosis with radiogenomics 

  Demetriou, Demetra Danielle; Lockhat, Zarina I.; Brzozowski, Luke; Saini, Kamal S.; Dlamini, Zodwa; Hull, Rodney (MDPI, 2024-03)

  Despite significant progress in the prevention, screening, diagnosis, prognosis, and therapy of breast cancer (BC), it remains a highly prevalent and life-threatening disease affecting millions worldwide. Molecular ...
• Holomics and artificial intelligence-driven precision oncology for medullary thyroid carcinoma : addressing challenges of a rare and aggressive disease 

  Luvhengo, Thifhelimbilu Emmanuel; Moeng, Maeyane Stephens; Sishuba, Nosisa T.; Makgoka, Malose; Jonas, Lusanda; Mamathuntsha, Tshilidzi G.; Mbambo, Thandanani; Kagodora, Shingirai B.; Dlamini, Zodwa (MDPI, 2024-10)

  BACKGROUND/OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare yet aggressive form of thyroid cancer comprising a disproportionate share of thyroid cancer-related mortalities, despite its low prevalence. MTC differs ...
• Breast cancer : do the current policies mean anything? 

  Botha, Susan; Ledibane, Neo R.T.; Dreosti, Lydia M. (Health Systems Trust, 2024-10)

  AIM : Breast cancer remains one of the most prevalent malignancies globally with a high mortality rate. South Africa has a number of policies in place designed to ensure that minimum delays are experienced by patients ...
• Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease 

  Chandler, Jennifer C.; Jafree, Daniyal J.; Malik, Saif; Pomeranz, Gideon; Ball, Mary; Kolatsi-Joannou, Maria; Piapi, Alice; Mason, William J.; Benest, Andrew V.; Bates, David O.; Letunovska, Aleksandra; Al-Saadi, Reem; Rabant, Marion; Boyer, Olivia; Pritchard-Jones, Kathy; Winyard, Paul J.; Mason, Andrew S.; Woolf, Adrian S.; Waters, Aoife M.; Long, David A. (Wiley, 2024-10)

  Please read abstract in the article.
• Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 

  Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)

  Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
• Reports of plant-derived nanoparticles for prostate cancer therapy 

  Elbagory, Abdulrahman M.; Hull, Rodney; Meyer, Mervin; Dlamini, Zodwa (MDPI, 2023-05-03)

  Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of ...
• Immunomodulatory gene-splicing dysregulation in tumorigenesis : unmasking the complexity 

  Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Yasasve, Madhavan; Dlamini, Zodwa; Damane, Botle Precious (MDPI, 2023-08-10)

  Cancer is a global health concern with rising incidence, morbidity, and mortality. The interaction between the tumor and immune cells within the tumor microenvironment is facilitated by signaling pathways driven by ...
• Drug standardization through pharmacognostic approaches and estimation of anticancer potential of chamomile (Matricaria chamomilla L.) using prostate-cancer cell lines : an in-vitro study 

  Khan, Nida; Kalam, Mohd Afsahul; Alam, Mohd Tauseef; Ul Haq, Syed Anam; Showket, Wasia; Dar, Zahoor A.; Rafiq, Nida; Mushtaq, Waseem; Rafeeqi, Towseef Amin; Dar, Mohammad Yunis; Akbar, Seema; Butt, Tariq Ahmad; Gani, Riehana; Majeed, Uzma; Chaudhary, Anis Ahmad; Rudayni, Hassan Ahmed; Al-Zharani, Mohammed; Shilbayeh, Sireen Abdul Rahim; Binsaleh, Ammena Yahia; El-Sheikh, Azza A.K.; Dlamini, Zodwa; Wani, Shabir Hussain; Khan, Shahanavaj; Masoodi, Khalid Z. (Ivyspring International Publisher, 2023-02-05)

  Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. ...
• The SARS-COV-2 seroprevalence among oncology patients 

  Kgatle, Mankgopo; Das, Rajesh; Lawal, Ismaheel Opeyemi; Boshomane, Tebatso M.G.; Mokoala, Kgomotso M.G.; Gaspar, Cattleya; Mbokazi, Lydia; Nkambule, Nonhlanhla; Gow, Veronique; Ndlovu, Honest; Mzizi, Yonwaba; Chalwe, Joseph; Diphofa, Jeaneth; Mokobodi, Dinah; Gxekwa, Nobuhle; Zongo, Lusanda; Maphosa, Tinashe; Vorster, Mariza; Bassa, Sheynaz; Venkatesan, Amouda; Khanyile, Richard; Munga, Yunus; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-01-09)

  Patients with cancer are presumed to be vulnerable to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe clinical outcomes due to the immunocompromised state mediated ...
• Imaging PARP upregulation with [123 I]I-PARPi SPECT/CT in small cell neuroendocrine carcinoma 

  Ndlovu, Honest; Lawal, Ismaheel Opeyemi; Mokoala, Kgomotso M.G.; Disenyane, Dineo; Nkambule, Nonhlahla; Bassa, Sheynaz; Mzizi, Yonwaba; Bida, Meshack; Sathekge, Mike Machaba (Society of Nuclear Medicine and Molecular Imaging, 2024-04)

  Please read abstract in the article.
• Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease 

  Alalwany, Roaa H.; Hawtrey, Tom; Morgan, Kevin; Morris, Jonathan C.; Donaldson, Lucy F.; Bates, David Owen (Frontiers Media, 2023-06-27)

  Please read abstract in the article.
• Targeting stem cells in the colorectal cancer microenvironment to avert drug resistance in pursuit of novel oncotherapies 

  Damane, Botle Precious; Marima, Rahaba; Mulaudzi, Thanyani; Dlamini, Zodwa (Biolife Sas, 2023-09)

  Several studies have demonstrated the heightened prevalence of colorectal cancer (CRC) among young black men. Most of these men present with already metastasized CRC. Cancer stem cells (CSCs) play a pivotal role in CRC ...
• In silico bioinformatics analysis on the role of long non-coding RNAs as drivers and gatekeepers of androgen-independent prostate cancer using LNCaP and PC-3 cells 

  Mbeje, Mandisa; Kandhavelu, Jeyalakshmi; Penny, Clement; Kgoebane-Maseko, Minah; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2023-09-01)

  Prostate cancer (PCa) is the leading cancer in men globally. The association between PCa and long non-coding RNAs (lncRNAs) has been reported. Aberrantly expressed lncRNAs have been documented in each of the cancer ...
• Selenium nanoparticles : a comprehensive examination of synthesis techniques and their diverse applications in medical research and toxicology studies 

  Sampath, Shobana; Sunderam, Veena; Manjusha, M.; Dlamini, Zodwa; Lawrance, Ansel Vishal (MDPI, 2024-02)

  Selenium is a trace and necessary micronutrient for human, animal, and microbial health. Many researchers have recently been interested in selenium nanoparticles (SeNPs) due to their biocompatibility, bioavailability, and ...
• Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 

  Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)

  Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
• Dissecting microbiome-derived SCFAs in prostate cancer : analyzing gut microbiota, racial disparities, and epigenetic mechanisms 

  Miya, Thabiso Victor; Marima, Rahaba; Damane, Botle Precious; Ledet, Elisa Marie; Dlamini, Zodwa (MDPI, 2023-08-14)

  Prostate cancer (PCa) continues to be the most diagnosed cancer and the second primary cause of fatalities in men globally. There is an abundance of scientific evidence suggesting that the human microbiome, together with ...

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