• From genes to clinical practice : exploring the genomic underpinnings of endometrial cancer 

  Molefi, Thulo; Mabonga, Lloyd; Hull, Rodney; Sebitloane, Motshedisi; Dlamini, Zodwa (MDPI, 2025-01)

  SIMPLE SUMMARY : Endometrial cancer is becoming more common, and current treatments do not work well for everyone. The study aims to understand how genetic changes drive this type of cancer and how these insights can improve ...
• Characterization of the genomic landscape in HPV-positive cervical and head and neck squamous cell carcinomas by whole genome next generation sequencing 

  Ren, Jianlan; Ma, Nian; Seckar, Tyler; Bassa, Sheynaz; Zetola, Nicola; Grover, Surbhi; Wei, Zhi; Robertson, Erle (International Institute of Anticancer Research, 2025-03)

  BACKGROUND/AIM : In this study, we provide a comprehensive characterization of HPV-positive primary cervical cancers (CC) and HPV-positive head and neck squamous cell carcinomas (HNSCC) through whole genome next-generation ...
• Long intergenic non-coding RNAs and BRCA1 in breast cancer pathogenesis : neighboring companions or nemeses? 

  Fadebi, Olalekan Olatunde; Miya, Thabiso Victor; Khanyile, Richard; Dlamini, Zodwa; Marima, Rahaba (MDPI, 2025-02)

  Breast cancer is one of the leading causes of mortality among women, primarily due to its complex molecular landscape and heterogeneous nature. The tendency of breast cancer patients to develop metastases poses significant ...
• Exosomal long non-coding RNAs in cancer : interplay, modulation, and therapeutic avenues 

  Marima, Rahaba; Basera, Afra; Miya, Thabiso Victor; Damane, Botle Precious; Kandhavelu, Jeyalakshmi; Mirza, Sheefa; Penny, Clement; Dlamini, Zodwa (KeAi Communications Co., 2024-09)

  In the intricate field of cancer biology, researchers are increasingly intrigued by the emerging role of exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, ...
• From incidence to intervention : a comprehensive look at breast cancer in South Africa 

  Dlamini, Zodwa; Molefi, Thulo; Khanyile, Richard; Mkhabele, Mahlori; Damane, Botle Precious; Kokoua, Alexandre; Bida, Meshack; Saini, Kamal S.; Chauke-Malinga, Nkhensani; Luvhengo, Thifhelimbilu Emmanuel; Hull, Rodney (Springer, 2024-03)

  The formidable impact of breast cancer extends globally, with South Africa facing pronounced challenges, including significant disparities in breast cancer screening, treatment and survival along ethnic and socioeconomic ...
• Tumor-infiltrating lymphocytes in melanoma : from prognostic assessment to therapeutic applications 

  Bida, Nndweleni Meshack; Miya, Thabiso Victor; Hull, Rodney; Dlamini, Zodwa (Frontiers Media, 2024-12)

  Malignant melanoma, the most aggressive form of skin cancer, is characterized by unpredictable growth patterns, and its mortality rate has remained alarmingly high over recent decades, despite various treatment approaches. ...
• Equitable inclusion of diverse populations in oncology clinical trials : deterrents and drivers 

  Vidal, L.; Dlamini, Zodwa; Qian, S.; Rishi, P.; Karmo, M.; Joglekar, N.; Abedin, S.; Previs, R.A.; Orbegoso, C.; Joshi, C.; Azim, H.A.; Karkaria, H.; Harris, M.; Mehrotra, R.; Berraondo, M.; Werutsky, G.; Gupta, S.; Niikura, N.; Chico, I.; Saini, Kamalveer S. (Elsevier, 2024-05)

  The burden of cancer exerts a disproportionate impact across different regions and population subsets. Disease-specific attributes, coupled with genetic and socioeconomic factors, significantly influence cancer treatment ...
• Directions to overcome therapy resistance in cancer 

  Nussinov, Ruth; Weichhart, Thomas; Dlamini, Zodwa; Gibbons, Don L.; Van Seuningen, Isabelle; Konen, Jessica; Ju, Huai-Qiang (Elsevier, 2024-06)

  Novel modalities for treatment of cancer have emerged because of advances in technology that have enabled expansion of our understanding of how cells transform to become cancerous and the role of the tumor microenvironment ...
• Editorial : Molecular targets for anticancer drug discovery and development 

  Ntwasa, Monde; Dlamini, Zodwa (Frontiers Media, 2024-04)

  No abstract available.
• Editorial : The RNA revolution and cancer 

  Dlamini, Zodwa; Ladomery, Michael R.; Kahraman, Abdullah (Frontiers Media, 2024-05)

  RNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor ...
• Exploring water-soluble South African Tulbaghia violacea Harv extract as a therapeutic approach for triple-negative breast cancer metastasis 

  Alaouna, Mohammed; Hull, Rodney; Molefi, Thulo; Khanyile, Richard; Mbodi, Langanani; Luvhengo, Thifhelimbilu Emmanuel; Chauke-Malinga, Nkhensani; Phakathi, Boitumelo P.; Penny, Clement; Dlamini, Zodwa (MDPI, 2024-10)

  Triple-negative breast cancer (TNBC) accounts for approximately 20% of all breast cancer cases and is characterized by a lack of estrogen, progesterone, and human epidermal growth factor 2 receptors. Current targeted ...
• The convergence of radiology and genomics : advancing breast cancer diagnosis with radiogenomics 

  Demetriou, Demetra Danielle; Lockhat, Zarina I.; Brzozowski, Luke; Saini, Kamal S.; Dlamini, Zodwa; Hull, Rodney (MDPI, 2024-03)

  Despite significant progress in the prevention, screening, diagnosis, prognosis, and therapy of breast cancer (BC), it remains a highly prevalent and life-threatening disease affecting millions worldwide. Molecular ...
• Holomics and artificial intelligence-driven precision oncology for medullary thyroid carcinoma : addressing challenges of a rare and aggressive disease 

  Luvhengo, Thifhelimbilu Emmanuel; Moeng, Maeyane Stephens; Sishuba, Nosisa T.; Makgoka, Malose; Jonas, Lusanda; Mamathuntsha, Tshilidzi G.; Mbambo, Thandanani; Kagodora, Shingirai B.; Dlamini, Zodwa (MDPI, 2024-10)

  BACKGROUND/OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare yet aggressive form of thyroid cancer comprising a disproportionate share of thyroid cancer-related mortalities, despite its low prevalence. MTC differs ...
• Breast cancer : do the current policies mean anything? 

  Botha, Susan; Ledibane, Neo R.T.; Dreosti, Lydia M. (Health Systems Trust, 2024-10)

  AIM : Breast cancer remains one of the most prevalent malignancies globally with a high mortality rate. South Africa has a number of policies in place designed to ensure that minimum delays are experienced by patients ...
• Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease 

  Chandler, Jennifer C.; Jafree, Daniyal J.; Malik, Saif; Pomeranz, Gideon; Ball, Mary; Kolatsi-Joannou, Maria; Piapi, Alice; Mason, William J.; Benest, Andrew V.; Bates, David O.; Letunovska, Aleksandra; Al-Saadi, Reem; Rabant, Marion; Boyer, Olivia; Pritchard-Jones, Kathy; Winyard, Paul J.; Mason, Andrew S.; Woolf, Adrian S.; Waters, Aoife M.; Long, David A. (Wiley, 2024-10)

  Please read abstract in the article.
• Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 

  Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)

  Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
• Reports of plant-derived nanoparticles for prostate cancer therapy 

  Elbagory, Abdulrahman M.; Hull, Rodney; Meyer, Mervin; Dlamini, Zodwa (MDPI, 2023-05-03)

  Plants have demonstrated potential in providing various types of phytomedicines with chemopreventive properties that can combat prostate cancer. However, despite their promising in vitro activity, the incorporation of ...
• Immunomodulatory gene-splicing dysregulation in tumorigenesis : unmasking the complexity 

  Maebele, Lorraine Tshegofatso; Mulaudzi, Thanyani Victor; Yasasve, Madhavan; Dlamini, Zodwa; Damane, Botle Precious (MDPI, 2023-08-10)

  Cancer is a global health concern with rising incidence, morbidity, and mortality. The interaction between the tumor and immune cells within the tumor microenvironment is facilitated by signaling pathways driven by ...
• Drug standardization through pharmacognostic approaches and estimation of anticancer potential of chamomile (Matricaria chamomilla L.) using prostate-cancer cell lines : an in-vitro study 

  Khan, Nida; Kalam, Mohd Afsahul; Alam, Mohd Tauseef; Ul Haq, Syed Anam; Showket, Wasia; Dar, Zahoor A.; Rafiq, Nida; Mushtaq, Waseem; Rafeeqi, Towseef Amin; Dar, Mohammad Yunis; Akbar, Seema; Butt, Tariq Ahmad; Gani, Riehana; Majeed, Uzma; Chaudhary, Anis Ahmad; Rudayni, Hassan Ahmed; Al-Zharani, Mohammed; Shilbayeh, Sireen Abdul Rahim; Binsaleh, Ammena Yahia; El-Sheikh, Azza A.K.; Dlamini, Zodwa; Wani, Shabir Hussain; Khan, Shahanavaj; Masoodi, Khalid Z. (Ivyspring International Publisher, 2023-02-05)

  Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. ...
• The SARS-COV-2 seroprevalence among oncology patients 

  Kgatle, Mankgopo; Das, Rajesh; Lawal, Ismaheel Opeyemi; Boshomane, Tebatso M.G.; Mokoala, Kgomotso M.G.; Gaspar, Cattleya; Mbokazi, Lydia; Nkambule, Nonhlanhla; Gow, Veronique; Ndlovu, Honest; Mzizi, Yonwaba; Chalwe, Joseph; Diphofa, Jeaneth; Mokobodi, Dinah; Gxekwa, Nobuhle; Zongo, Lusanda; Maphosa, Tinashe; Vorster, Mariza; Bassa, Sheynaz; Venkatesan, Amouda; Khanyile, Richard; Munga, Yunus; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-01-09)

  Patients with cancer are presumed to be vulnerable to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe clinical outcomes due to the immunocompromised state mediated ...

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