• Editorial : Cholesterol and cancer drug resistance : molecular, signaling, and therapeutic aspects 

  Kaur, Mandeep; Dlamini, Zodwa (Frontiers Media S.A., 2022-09-15)

  No abstract available.
• Microbiomics in collusion with the nervous system in carcinogenesis : diagnosis, pathogenesis and treatment 

  Hull, Rodney; Lolas, Georgios; Makrogkikas, Stylianos; Jensen, Lasse D.; Syrigos, Konstantinos N.; Evangelou, George; Padayachy, Llewellyn; Egbor, Cyril; Mehrotra, Ravi; Makhafola, Tshepiso Jan; Oyomno, Meryl; Dlamini, Zodwa (MDPI, 2021-10-11)

  The influence of the naturally occurring population of microbes on various human diseases has been a topic of much recent interest. Not surprisingly, continuously growing attention is devoted to the existence of a gut ...
• Genomics and molecular analysis of RPL9 and LIAS in lung cancer : emerging implications in carcinogenesis 

  Dlamini, Zodwa; Marima, Rahaba; Hull, Rodney; Syrigos, Konstantinos N.; Lolas, Georgios; Mphahlele, Lebogang; Mbita, Zukile (Elsevier, 2021-08-11)

  Worldwide, lung cancer is a leading cause of cancer-related deaths and is the most commonly diagnosed form of cancer. A major characteristic of lung cancer is its profound clinical, histological and molecular heterogeneity. This ...
• Genetic drivers of head and neck squamous cell carcinoma : aberrant splicing events, mutational burden, hpv infection and future targets 

  Dlamini, Zodwa; Alaouna, Mohammed; Mbatha, Sikhumbuzo Z.; Bhayat, Ahmed; Mabongo, Mzubanzi; Chatziioannou, Aristotelis; Hull, Rodney (MDPI, 2021-03-15)

  Head and neck cancers include cancers that originate from a variety of locations. These include the mouth, nasal cavity, throat, sinuses, and salivary glands. These cancers are the sixth most diagnosed cancers worldwide. ...
• Immunosuppressive signaling pathways as targeted cancer therapies 

  Setlai, Botle Precious; Hull, Rodney; Bida, Nndweleni Meshack; Durandt, Chrisna; Mulaudzi, Thanyani Victor; Chatziioannou, Aristotelis; Dlamini, Zodwa (MDPI, 2022-03)

  Immune response has been shown to play an important role in defining patient prognosis and response to cancer treatment. Tumor-induced immunosuppression encouraged the recent development of new chemotherapeutic agents that ...
• MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets 

  Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen Bates; Dlamini, Zodwa (MDPI, 2021-12-02)

  Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...
• The profiling, identification, quantification and analysis of differentially expressed genes (DEGs) in response to drug treatment in lung cancer 

  Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Elsevier, 2021)

  The profiling and identification of genes that are differentially expressed is frequently used to underpin the underlying molecular mechanisms of biological conditions and provides a molecular foothold on biological questions ...
• The catastrophic HPV/HIV dual viral oncogenomics in concert with dysregulated alternative splicing in cervical cancer 

  Marima, Rahaba; Hull, Rodney; Lolas, Georgios; Syrigos, Konstantinos N.; Kgoebane-Maseko, Minah; Kaufmann, Andreas Martin; Dlamini, Zodwa (MDPI Publishing, 2021-09-18)

  Cervical cancer is a public health problem and has devastating effects in low-to-middle income countries (LTMICs) such as the sub-Saharan African (SSA) countries. Infection by the human papillomavirus (HPV) is the main ...
• HIV-associated cancer biomarkers : a requirement for early diagnosis 

  Dlamini, Zodwa; Mbele, Mzwandile; Makhafola, Tshepiso J.; Hull, Rodney; Marima, Rahaba (MDPI Publishing, 2021-07-29)

  Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest number of HIV infections. Malignancies previously associated ...
• Splicing genomics events in cervical cancer : insights for phenotypic stratification and biomarker potency 

  Francies, Flavia Zita; Bassa, Sheynaz; Chatziioannou, Aristotelis; Kaufmann, Andreas Martin; Dlamini, Zodwa (MDPI, 2021-01-20)

  Gynaecological cancers are attributed to the second most diagnosed cancers in women after breast cancer. On a global scale, cervical cancer is the fourth most common cancer and the most common cancer in developing countries ...
• Role and merits of green based nanocarriers in cancer treatment 

  Elbagory, Abdulrahman M.; Marima, Rahaba; Dlamini, Zodwa (MDPI, 2021-11-13)

  The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the ...
• Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis 

  Marima, Rahaba; Hull, Rodney; Penny, Clement; Dlamini, Zodwa (Elsevier, 2021-01)

  Aurora Kinase B (AURKB) and Mitotic Arrest Deficient 2 Like 2 (MAD2L2) are emerging anticancer therapeutic targets. AURKB and MAD2L2 are the least well studied members of their protein families, compared to AURKA and ...
• Long non-coding RNAs (LncRNAs), viral oncogenomics, and aberrant splicing events : therapeutics implications 

  Hull, Rodney; Mbita, Zukile; Dlamini, Zodwa (e-Century Publishing, 2021-03-15)

  It has been estimated that worldwide up to 10% of all human cancers are the result of viral infection, with 7.2% of all cancers in the developed world have a viral aetiology. In contrast, 22.9% of infections in the developing ...
• Breast cancer in low-middle income countries : abnormality in splicing and lack of targeted treatment options 

  Francies, Flavia Zita; Hull, Rodney; Khanyile, Richard; Dlamini, Zodwa (e-Century Publishing, 2020-05)

  Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have ...
• Is targeting dysregulation in apoptosis splice variants in Mycobacterium tuberculosis (MTB) host interactions and splicing factors resulting in immune evasion by MTB strategies a possibility? 

  Dlamini, Zodwa; Alaouna, Mohammed; Cholo, Moloko C.; Hull, Rodney (Elsevier, 2020-09)

  Mycobacterium tuberculosis (Mtb), is one of the foremost organisms causing mortality in humans, and has been for most of human history. When faced with an infection the human immune system is ordinarily very competent in ...
• Aberrant splicing events and epigenetics in viral oncogenomics : current therapeutic strategies 

  Francies, Flavia Zita; Dlamini, Zodwa (MDPI, 2021-01)

  Cancer is a global burden and is the second leading cause of mortality. It is largely a non-communicable disease attributable to the accumulation of damaged DNA and deleterious mutations in vital genes caused by exposure ...
• Many voices in a choir: tumor-induced neurogenesis and neuronal driven alternative splicing sound like suspects in tumor growth and dissemination 

  Dlamini, Zodwa; Mathabe, Kgomotso; Padayachy, Llewellyn; Marima, Rahaba; Evangelou, George; Syrigos, Konstantinos N.; Bianchi, Arianna; Lolas, Georgios; Hull, Rodney (MDPI, 2021-05)

  During development, as tissues expand and grow, they require circulatory, lymphatic, and nervous system expansion for proper function and support. Similarly, as tumors arise and develop, they also require the expansion ...
• Prognostic alternative splicing signatures in esophageal carcinoma 

  Dlamini, Zodwa; Hull, Rodney; Mbatha, Sikhumbuzo Z.; Alaouna, Mohammed; Qiao, You-Lin; Yu, Herbert; Chatziioannou, Aristotelis (Dove Medical Press, 2021)

  Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of ...
• Hypercoagulability in COVID-19 

  Wessels, Pieter Frederik (South African Heart Association, 2020-11)

  COVID-19 is associated with a hypercoagulable state that may present as pulmonary thrombosis, pulmonary embolism, and venous and arterial thrombosis. Suggested pathogenesis include direct infection of the endothelial cell ...
• In vitro antibacterial activity of Loxostylis alata extracts and isolated compounds against Salmonella species 

  Gado, Dorcas A.; Abdalla, Muna Ali; Ahmed, Aroke Shahid; Madikizela, Balungile; Nkadimeng, Sanah Malomile; Ehlers, Marthie Magdaleen; McGaw, Lyndy Joy (BMC, 2021-04)

  BACKGROUND: Owing to antibiotic resistance, alternative antimicrobials from medicinal plants are receiving attention as leads for anti-infective agents. This study aimed to investigate selected tree species and their ...

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