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Browsing Research Articles (Medical Oncology) by UP Author "Molefi, Thulo"
Now showing items 1-8 of 8
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Dlamini, Zodwa; Skepu, Amanda; Kim, Namkug; Mkhabele, Mahlori; Khanyile, Richard; Molefi, Thulo; Mbatha, Sikhumbuzo; Setlai, Botle; Mulaudzi, Thanyani Victor; Mabongo, Mzubanzi; Bida, Nndweleni Meshack; Kgoebane-Maseko, Minah; Mathabe, Kgomotso; Lockhat, Zarina I.; Kgokolo, C.M.; Chauke-Malinga, Nkhensani; Ramagaga, Serwalo; Hull, Rodney (Elsevier, 2022)Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic ...
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Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (MDPI, 2023-08-07)Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
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Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
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Francies, Flavia Zita; Marima, Rahaba; Hull, Rodney; Molefi, Thulo; Dlamini, Zodwa (e-Century Publishing, 2020-10)Endometrial cancer, also known as uterine cancer, is the most common gynaecological malignancy with burgeoning incidence and mortality rates globally. Racial disparity, socioeconomic and geographical differences are important ...
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Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen; Dlamini, Zodwa (MDPI, 2021-12-02)Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...
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Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
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Marima, Rahaba; Hull, Rodney; Mbeje, Mandisa Pearl; Molefi, Thulo; Mathabe, Kgomotso; Elbagory, Abdulrahman M.; Demetriou, Demetra Danielle; Dlamini, Zodwa (MDPI, 2022-01-06)Precision oncology can be defined as molecular profiling of tumors to identify targetable alterations. Emerging research reports the high mortality rates associated with type II endometrial cancer in black women and with ...
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Hull, Rodney; Marima, Rahaba; Alaouna, Mohammed; Demetriou, Demetra Danielle; Reis, Rui Manuel; Molefi, Thulo; Dlamini, Zodwa (MDPI, 2022-07-18)About 15% of all human cancers have a viral etiology. Although progress has been made, understanding the viral oncogenesis and associated molecular mechanisms remain complex. The discovery of cellular miRNAs has led to ...
Now showing items 1-8 of 8