Browsing Research Articles (Medical Oncology) by UP Author "Khanyile, Richard"

Browsing Research Articles (Medical Oncology) by UP Author "Khanyile, Richard"

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  • AI and precision oncology in clinical cancer genomics : from prevention to targeted cancer therapies-an outcomes based patient care 
    Dlamini, Zodwa; Skepu, Amanda; Kim, Namkug; Mkhabele, Mahlori; Khanyile, Richard; Molefi, Thulo; Mbatha, Sikhumbuzo; Setlai, Botle; Mulaudzi, Thanyani Victor; Mabongo, Mzubanzi; Bida, Nndweleni Meshack; Kgoebane-Maseko, Minah; Mathabe, Kgomotso; Lockhat, Zarina I.; Kgokolo, C.M.; Chauke-Malinga, Nkhensani; Ramagaga, Serwalo; Hull, Rodney (Elsevier, 2022)
    Precision medicine is the personalization of medicine to suit a specific group of people or even an individual patient, based on genetic or molecular profiling. This can be done using genomic, transcriptomic, epigenomic ...
  • Alternative splicing events and their clinical significance in colorectal cancer : targeted therapeutic opportunities 
    Manabile, Mosebo Armstrong; Hull, Rodney; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (MDPI, 2023-08-07)
    Colorectal cancer (CRC) ranks as one of the top causes of cancer mortality worldwide and its incidence is on the rise, particularly in low-middle-income countries (LMICs). There are several factors that contribute to the ...
  • Breast cancer in low-middle income countries : abnormality in splicing and lack of targeted treatment options 
    Francies, Flavia Zita; Hull, Rodney; Khanyile, Richard; Dlamini, Zodwa (e-Century Publishing, 2020-05)
    Breast cancer is a common malignancy among women worldwide. Regardless of the economic status of a country, breast cancer poses a burden in prevention, diagnosis and treatment. Developed countries such as the U.S. have ...
  • Genomic interplay between neoneurogenesis and neoangiogenesis in carcinogenesis : therapeutic interventions 
    Dlamini, Zodwa; Khanyile, Richard; Molefi, Thulo; Damane, Botle Precious; Bates, David Owen; Hull, Rodney (MDPI, 2023-03-16)
    Angiogenesis, the generation of new blood vessels, is one of the hallmarks of cancer. The growing tumor requires nutrients and oxygen. Recent evidence has shown that tumors release signals to attract new nerve fibers and ...
  • MicroRNA and alternative mRNA splicing events in cancer drug response/resistance : potent therapeutic targets 
    Marima, Rahaba; Francies, Flavia Zita; Hull, Rodney; Molefi, Thulo; Oyomno, Meryl; Khanyile, Richard; Mbatha, Sikhumbuzo Z.; Bates, David Owen; Dlamini, Zodwa (MDPI, 2021-12-02)
    Cancer is a multifaceted disease that involves several molecular mechanisms including changes in gene expression. Two important processes altered in cancer that lead to changes in gene expression include altered microRNA ...
  • Overcoming the challenges of phytochemicals in triple negative breast cancer therapy : the path forward 
    Alaouna, Mohammed; Penny, Clement; Hull, Rodney; Molefi, Thulo; Chauke-Malinga, Nkhensani; Khanyile, Richard; Makgoka, Malose; Bida, Meshack; Dlamini, Zodwa (MDPI, 2023-06-16)
    Triple negative breast cancer (TNBC) is a very aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptor expression. TNBC is thought to be produced by Wnt, Notch, TGF-beta, and VEGF pathway ...
  • The SARS-COV-2 seroprevalence among oncology patients 
    Kgatle, Mankgopo; Das, Rajesh; Lawal, Ismaheel Opeyemi; Boshomane, Tebatso M.G.; Mokoala, Kgomotso M.G.; Gaspar, Cattleya; Mbokazi, Lydia; Nkambule, Nonhlanhla; Gow, Veronique; Ndlovu, Honest; Mzizi, Yonwaba; Chalwe, Joseph; Diphofa, Jeaneth; Mokobodi, Dinah; Gxekwa, Nobuhle; Zongo, Lusanda; Maphosa, Tinashe; Vorster, Mariza; Bassa, Sheynaz; Venkatesan, Amouda; Khanyile, Richard; Munga, Yunus; Ebenhan, Thomas; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (MDPI, 2023-01-09)
    Patients with cancer are presumed to be vulnerable to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe clinical outcomes due to the immunocompromised state mediated ...