Browsing Research Articles (Medical Oncology) by Subject "DNA damage response (DDR)"

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The dual protease inhibitor lopinavir/ritonavir (LPV/r) exerts genotoxic stress on lung cells

Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020-12)

The Sub-Saharan countries, particularly South Africa has the largest number of people living with HIV, accompanied by the largest antiretroviral treatment (ART) programme in the world. The Highly Active Antiretroviral ...
Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis

Marima, Rahaba; Hull, Rodney; Penny, Clement; Dlamini, Zodwa (Elsevier, 2021-01)

Aurora Kinase B (AURKB) and Mitotic Arrest Deficient 2 Like 2 (MAD2L2) are emerging anticancer therapeutic targets. AURKB and MAD2L2 are the least well studied members of their protein families, compared to AURKA and ...

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