dc.contributor.author |
Callaby, R.
|
|
dc.contributor.author |
Hanotte, Olivier
|
|
dc.contributor.author |
Conradie van Wyk, Ilana
|
|
dc.contributor.author |
Kiara, Henry
|
|
dc.contributor.author |
Toye, Philip G.
|
|
dc.contributor.author |
Mbole-Kariuki, Mary Ndila
|
|
dc.contributor.author |
Jennings, Amy
|
|
dc.contributor.author |
Thumbi, Samuel Mwangi
|
|
dc.contributor.author |
Coetzer, Jacobus A.W.
|
|
dc.contributor.author |
Bronsvoort, Barend Mark de Clare
|
|
dc.contributor.author |
Knott, S.A.
|
|
dc.contributor.author |
Woolhouse, Mark E.J.
|
|
dc.contributor.author |
Kruuk, Loeske E.B.
|
|
dc.date.accessioned |
2014-11-13T06:47:58Z |
|
dc.date.available |
2014-11-13T06:47:58Z |
|
dc.date.issued |
2015-03 |
|
dc.description.abstract |
Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual
phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight
and a suite of haematological measures, in a cohort of indigenous zebu calves inWestern Kenya, using relatedness matrices
reconstructed from single nucleotide polymorphism (SNP) genotypes. Strongyle egg count was heritable (h2 = 23·9%,
S.E. = 11·8%) and we also found heritability of white blood cell counts (WBC) (h2 = 27·6%, S.E. = 10·6%). All the traits
investigated showed negative phenotypic covariances with strongyle egg count throughout the first year: high worm counts
were associated with low values of WBC, red blood cell count, total serum protein and absolute eosinophil count.
Furthermore, calf body weight at 1 week old was a significant predictor of strongyle EPG at 16–51 weeks, with smaller calves
having a higher strongyle egg count later in life. Our results indicate a genetic basis to strongyle EPG in this population, and
also reveal consistently strong negative associations between strongyle infection and other important aspects of the
multivariate phenotype. |
en_US |
dc.description.librarian |
am2014 |
en_US |
dc.description.sponsorship |
The IDEAL project was funded by the Wellcome Trust
(grant No. 079445). RC is funded by anNERCstudentship
with the James Hutton Institute as a CASE partner. LK is
supported by an Australian Research Council Future
Fellowship. |
en_US |
dc.description.uri |
http://journals.cambridge.org/action/displayJournal?jid=PAR |
en_US |
dc.identifier.citation |
Callaby, R, Hanotte, O, Conradie Van Wyk, I, Kiara, H, Toye, P, Mbole-Kariuki, MN, Jennings, A, Thumbi, SM, Coetzer, JAW, Bronsvoort, BMDC, Knott, SA, Woolhouse, MEJ & Kruuk, LEB 2015, 'Variation and covariation in strongyle infection in East African shorthorn zebu calves', Parasitology, vol. 142, no. 3, pp. 499-511. |
en_US |
dc.identifier.issn |
0031-1820 (print) |
|
dc.identifier.issn |
1469-8161 (online) |
|
dc.identifier.other |
10.1017/S0031182014001498 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/42569 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Cambridge University Press |
en_US |
dc.relation.requires |
Adobe Acrobat Reader |
en |
dc.rights |
© Cambridge University Press 2014. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence. |
en_US |
dc.subject |
Gastrointestinal parasites |
en_US |
dc.subject |
Strongyle |
en_US |
dc.subject |
Indigenous cattle |
en_US |
dc.subject |
Kenya |
en_US |
dc.subject |
Heritability |
en_US |
dc.subject |
Haematology |
en_US |
dc.subject |
Parasite infection |
en_ZA |
dc.subject |
East African short-horn zebus |
en_ZA |
dc.subject.lcsh |
Zebus |
en_ZA |
dc.title |
Variation and covariation in strongyle infection in East African shorthorn zebu calves |
en_US |
dc.type |
Article |
en_US |