HIV is not indicated in the aetiology of Castleman’s disease. However, it impacts on the prevalence and natural history of
this disease and signi cantly on the disease progression. Castleman’s disease is a uni- or multicentric disease of the lymph
node with or without polyclonal proliferation of B-cells. It is a morphologically distinct form of lymph node hyperplasia
and is characterised by signi cant architectural changes in all lymphatic compartments. Histopathologically, the disease is
classi ed into two major subtypes: the hyaline-vascular type and the plasma-cell type. A mixed type is also identi ed, as there
are frequent transitions between the types. e diagnosis of Castleman’s disease needs to be made histologically. Treatment
modalities include surgery, which is curative for unicentric disease, and systemic therapy, which is needed for multicentric
disease. is case highlights the diagnostic value of lymph node excision biopsy in HIV-infected patients.