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Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by Subject "Plasmodium falciparum"

Now showing items 1-14 of 14

Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine‑tolerance molecular markers following 18 years of artemisinin‑based combination therapy use in Mpumalanga Province, South Africa (2001–2018)

Raman, Jaishree; Kagoro, Frank M.; Mabuza, Aaron; Malatje, Gillian; Reid, Anthony; Barnes, Karen I. (BioMed Central, 2019-08-22)

BACKGROUND : The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring ...
Benzimidazole derivatives are potent against multiple life cycle stages of Plasmodium falciparum malaria parasites

Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)

The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development

Von Gruning, Hilde; Coradin, Mariel; Mendoza, Mariel R.; Reader, Janette; Sidoli, Simone; Garcia, Benjamin A.; Birkholtz, Lyn-Marie (Elsevier, 2022-03)

Histone posttranslational modifications (PTMs) frequently co-occur on the same chromatin domains or even in the same molecule. It is now established that these “histone codes” are the result of cross talk between enzymes ...
The ecdysone receptor regulates several key physiological factors in Anopheles funestus

Maharaj, Surina; Ekoka, Elodie; Erlank, Erica; Nardini, Luisa; Reader, Janette; Birkholtz, Lyn-Marie; Koekemoer, Lizette L. (BMC, 2022-03)

BACKGROUND : Malaria is a devastating disease, transmitted by female Anopheles mosquitoes infected with Plasmodium parasites. Current insecticide-based strategies exist to control the spread of malaria by targeting vectors. ...
hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole

Mambwe, Dickson; Coertzen, Dina; Leshabane, Meta Kgaogelo; Mulubwa, Mwila; Njoroge, Mathew; Gibhard, Liezl; Girling, Gareth; Wicht, Kathryn J.; Lee, Marcus C.S.; Wittlin, Sergio; Moreira, Diogo Rodrigo Magalhaes; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2024-03)

Please read abstract in the article.
In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae)

Mabuza, J. Mcebisi; Kaiser, Marcel; Bapela, Mahwahwatse Johanna (Elsevier, 2022-11)

ETHNOPHARMACOLOGICAL RELEVANCE : The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms. AIM OF STUDY : The main aim of this study was to evaluate ...
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites

Mianda, S.M.; Invernizzi, Luke; Van der Watt, Mariette Elizabeth; Reader, Janette; Moyo, Phanankosi; Birkholtz, Lyn-Marie; Maharaj, Vinesh J. (Elsevier, 2022-10)

Please abstract in the article.
Machine learning approaches identify chemical features for stage-specific antimalarial compounds

Van Heerden, Ashleigh; Turon, Gemma; Duran-Frigola, Miquel; Pillay, Nelishia; Birkholtz, Lyn-Marie (American Chemical Society, 2023-11-07)

Efficacy data from diverse chemical libraries, screened against the various stages of the malaria parasite Plasmodium falciparum, including asexual blood stage (ABS) parasites and transmissible gametocytes, serve as a ...
Making data map-worthy—enhancing routine malaria data to support surveillance and mapping of Plasmodium falciparum anti-malarial resistance in a pre-elimination sub-Saharan African setting : a molecular and spatiotemporal epidemiology study

Kagoro, Frank M.; Allen, Elizabeth; Mabuza, Aaron; Workman, Lesley; Magagula, Ray; Kok, Gerdalize; Davies, Craig; Malatje, Gillian; Guerin, Philippe J.; Dhorda, Mehul; Maude, Richard J.; Raman, Jaishree; Barnes, Karen I. (Springer, 2022-06)

BACKGROUND : Independent emergence and spread of artemisinin-resistant Plasmodium falciparum malaria have recently been confirmed in Africa, with molecular markers associated with artemisinin resistance increasingly detected. ...
Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model

Mambwe, Dickson; Korkor, Constance M.; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta Kgaogelo; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J.; Chibale, Kelly (American Chemical Society, 2022-12)

Please read abstract in the article.
Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa

Gwarinda, Hazel B.; Tessema, Sofonias K.; Raman, Jaishree; Greenhouse, Bryan; Birkholtz, Lyn-Marie (BMC, 2021-02)

BACKGROUND : South Africa aims to eliminate malaria transmission by 2023. However, despite sustained vector control efforts and case management interventions, the Vhembe District remains a malaria transmission hotspot. To ...
Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

Mianda, Sephora Mutombo; Moyo, Phanankosi; Maboane, Suzan; Birkholtz, Lyn-Marie; Maharaj, Vinesh J. (Taylor and Francis, 2024)

Please read abstract in the article.
Semi-synthetic analogues of cryptolepine as a potential source of sustainable drugs for the treatment of malaria, human African trypanosomiasis, and cancer

Abacha, Yabalu Z.; Forkuo, Arnold Donkor; Gbedema, Stephen Y.; Mittal, Nimisha; Ottilie, Sabine; Rocamora, Frances; Winzeler, Elizabeth A.; Van Schalkwyk, Donelly A.; Kelly, John M.; Taylor, Martin C.; Reader, Janette; Birkholtz, Lyn-Marie; Lisgarten, David R.; Cockcroft, Jeremy K.; Lisgarten, John N.; Palmer, Rex A.; Talbert, Rosemary C.; Shnyder, Steven D.; Wright, Colin W. (Frontiers Media, 2022-04)

The prospect of eradicating malaria continues to be challenging in the face of increasing parasite resistance to antimalarial drugs so that novel antimalarials active against asexual, sexual, and liver-stage malaria parasites ...
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli

Makhoba, Xolani Henry; Burger, Adelle; Coertzen, Dina; Zininga, Tawanda; Birkholtz, Lyn-Marie; Shonhai, Addmore (Public Library of Science, 2016-03-31)

S-adenosylmethionine decarboxylase (PfAdoMetDC) from Plasmodium falciparum is a prospective antimalarial drug target. The production of recombinant PfAdoMetDC for biochemical validation as a drug target is important. The ...

Now showing items 1-14 of 14

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Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by Subject "Plasmodium falciparum"

Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by Subject "Plasmodium falciparum"

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