hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole

Mambwe, Dickson; Coertzen, Dina; Leshabane, Meta Kgaogelo; Mulubwa, Mwila; Njoroge, Mathew; Gibhard, Liezl; Girling, Gareth; Wicht, Kathryn J.; Lee, Marcus C.S.; Wittlin, Sergio; Moreira, Diogo Rodrigo Magalhaes; Birkholtz, Lyn-Marie; Chibale, Kelly

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hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole

Mambwe, Dickson; Coertzen, Dina; Leshabane, Meta Kgaogelo; Mulubwa, Mwila; Njoroge, Mathew; Gibhard, Liezl; Girling, Gareth; Wicht, Kathryn J.; Lee, Marcus C.S.; Wittlin, Sergio; Moreira, Diogo Rodrigo Magalhaes; Birkholtz, Lyn-Marie; Chibale, Kelly

URI: http://hdl.handle.net/2263/97228

Date: 2024-03

Abstract:

Please read abstract in the article.

Description:

SUPPLEMENTARY INFORMATION : Experimental procedures and characterization data of synthetic intermediates (5a–5f, 6a–6f, 13, and 15) and target compounds (7–12 and 15); biochemical assay protocols, including solubility and cross-resistance studies; H NMR spectra of representative target compounds.

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