• The prevalence of childhood asthma, respiratory symptoms and associated air pollution sources among adolescent learners in selected schools in Vhembe District, South Africa 

  Rathogwa-Takalani, Funzani; Mudau, Thabelo Rodney; Patrick, Sean Mark; Shirinde, Joyce; Voyi, K.V.V. (Kuku) (MDPI, 2024-11-20)

  This study investigated the prevalence of childhood asthma and respiratory symptoms with their associated air pollution sources among adolescents aged 13–14 years residing in a Malaria-endemic region. METHODS : A cross-sectional ...
• Synthesis and SAR studies of acyl-thiourea platinum(II) complexes yield analogs with dual-stage antiplasmodium activity 

  Ishmail, Fatima-Zahra; Coertzen, Dina; Tshabalala, Sizwe; Leshabane, Meta Kgaogelo; Da Rocha, Shanté; Njoroge, Mathew; Gibhard, Liezl; Birkholtz, Lyn-Marie; Woodland, John G.; Egan, Timothy J.; Wicht, Kathryn J.; Chibale, Kelly (American Chemical Society, 2025-02)

  Mixed-ligand platinum(II) complexes incorporating bipyridine and acyl-thiourea ligands were synthesized and evaluated for their in vitro growth inhibitory activity against the human malaria parasite Plasmodium falciparum ...
• Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials 

  Naude, Mariska; Van Heerden, Ashleigh; Reader, Janette; Van der Watt, Mariette Elizabeth; Niemand, Jandeli; Joubert, Dore; Siciliano, Giulia; Alano, Pietro; Njoroge, Mathew; Chibale, Kelly; Herreros, Esperanza; Leroy, Didier; Birkholtz, Lyn-Marie (Nature Research, 2024-11-15)

  Novel antimalarial compounds targeting both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum, would greatly benefit malaria elimination strategies. However, most compounds ...
• Evaluation of the malaria case surveillance system in KwaZulu-Natal Province, South Africa, 2022 : a focus on DHIS2 

  Mabona, Maxwell; Zwane, Thembekile; Raman, Jaishree; Kuonza, Lazarus R.; Mhlongo, Babongile; Phafane, Poncho (BioMed Central, 2024-02-14)

  BACKGROUND South Africa set a target to eliminate malaria by 2023, with KwaZulu-Natal (KZN) Province the malariaendemic province closest to achieving this goal. Objective two of the National Malaria Elimination Strategic ...
• Helminth parasites of impalas, Aepyceros melampus, in eastern southern Africa, collected during 1973 to 2007 

  Horak, Ivan Gerard; Junker, K.; Braack, L.E.O.; Gallivan, G.J. (Medpharm Publications, 2024-03)

  This paper summarises published and unpublished data on helminths collected systematically from 424 impalas at 11 localities in eastern southern Africa, from St. Lucia in KwaZulu-Natal (KZN) to the Tuli Block in north-eastern ...
• Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates 

  Greyling, Nicola; Van der Watt, Mariette Elizabeth; Gwarinda, Hazel B.; Van Heerden, Ashleigh; Greenhouse, Bryan; Leroy, Didier; Niemand, Jandeli; Birkholtz, Lyn-Marie (American Society for Microbiology, 2024-03)

  Malaria elimination requires interventions able to target both the asexual blood stage (ABS) parasites and transmissible gametocyte stages of Plasmodium falciparum. Lead antimalarial candidates are evaluated against ...
• Association between prenatal exposure to indoor residual spraying insecticides and infection rates among South African children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) 

  Davis, Brooklyn; Eskenazi, Brenda; Bornman, Maria S. (Riana); Obida, Muvhulawa; Chevrier, Jonathan (Elsevier, 2024-03)

  Please read abstract in the article.
• Towards integrated malaria molecular surveillance in Africa 

  Dada, Nsa; Simpson, Victoria J.; Amenga-Etego, Lucas N.; Oriero, Eniyou; Miotto, Olivo; Torok, Mili Estee; Juma, Elijah O.; Williams, Nana Aba; Rajatileka, Shavanthi; Ariani, Cristina V.; Raman, Jaishree; Ishengoma, Deus S. (Elsevier, 2024-11)

  Integrated malaria molecular surveillance (iMMS) systems are essential for Africa's expanding malaria genomics initiatives. Here we highlight a few initiatives and demonstrate how iMMS can support evidence-based decisions ...
• House screening reduces exposure to indoor host-seeking and biting malaria vectors : evidence from rural South-East Zambia 

  Saili, Kochelani; De Jager, Christiaan; Masaninga, Freddie; Sangoro, Onyango P.; Nkya, Theresia E.; Likulunga, Likulunga Emmanuel; Chirwa, Jacob; Hamainza, Busiku; Chanda, Emmanuel; Fillinger, Ulrike; Mutero, Clifford Maina (MDPI, 2024-01-15)

  This study evaluated the impact of combining house screens with long-lasting insecticidal nets (LLINs) on mosquito host-seeking, resting, and biting behavior. Intervention houses received house screens and LLINs, while ...
• The Tuberculosis drug candidate SQ109 and its analogs have multistage activity against Plasmodium falciparum 

  Watson, Savannah Jade; Van der Watt, Mariette Elizabeth; Theron, Anjo; Reader, Janette; Tshabalala, Sizwe; Erlank, Erica; Koekemoer, Lizette L.; Naude, Mariska; Stampolaki, Marianna; Adewole, Feyisola; Sadowska, Katie; Pérez-Lozano, Pilar; Turcu, Andreea L.; Vázquez, Santiago; Ko, Jihee; Mazurek, Ben; Singh, Davinder; Malwal, Satish R.; Njoroge, Mathew; Chibale, Kelly; Onajole, Oluseye K.; Kolocouris, Antonios; Oldfield, Eric; Birkholtz, Lyn-Marie (American Chemical Society, 2024-08)

  Toward repositioning the antitubercular clinical candidate SQ109 as an antimalarial, analogs were investigated for structure−activity relationships for activity against asexual blood stages of the human malaria parasite ...
• Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration 

  Mbaba, Mziyanda; Golding, Taryn M.; Omondi, Reinner O.; Mohunlal, Roxanne; Egan, Timothy J.; Reader, Janette; Birkholtz, Lyn-Marie; Smith, Gregory S. (Elsevier, 2024-05)

  Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising emergence of resistant malaria parasites, ...
• Community perceptions, acceptability, and the durability of house screening interventions against exposure to malaria vectors in Nyimba district, Zambia 

  Saili, Kochelani; De Jager, Christiaan; Masaninga, Freddie; Chisanga, Brian; Sinyolo, Andy; Chiwaula, Japhet; Chirwa, Jacob; Hamainza, Busiku; Chanda, Emmanuel; Bakyaita, Nathan N.; Mutero, Clifford Maina (BMC, 2024-01)

  BACKGOUND: House screening remains conspicuously absent in national malaria programs despite its recognition by the World Health Organization as a supplementary malaria vector-control intervention. This may be attributed, ...
• Anopheles rufipes implicated in malaria transmission both indoors and outdoors alongside Anopheles funestus and Anopheles arabiensis in rural south-east Zambia 

  Saili, Kochelani; De Jager, Christiaan; Sangoro, Onyango P.; Nkya, Theresia E.; Masaninga, Freddie; Mwenya, Mwansa; Sinyolo, Andy; Hamainza, Busiku; Chanda, Emmanuel; Fillinger, Ulrike; Mutero, Clifford Maina (BMC, 2023-03-16)

  BACKGROUND : The primary malaria vector-control interventions, indoor residual spraying and long-lasting insecticidal nets, are effective against indoor biting and resting mosquito species. Consequently, outdoor biting and ...
• Correlating the density and refractive index of ternary liquid mixtures 

  Dzingai, Pethile; Focke, Walter Wilhelm; Ramjee, Shatish; Khosa, Pretty; Nobunga, Ripfumelo A. (Springer, 2023-11)

  Some physical properties of ideal solutions, e.g. the molar volume and the molar refraction, vary linearly with composition. Others can be expressed, either as ratios or as products of two other properties which vary ...
• Species composition, seasonal abundance, and biting behavior of malaria vectors in rural Conhane Village, Southern Mozambique 

  Salome, Graca; Riddin, Megan A.; Braack, L.E.O. (MDPI, 2023-02-17)

  Malaria vector surveillance provides important data to inform the effective planning of vector control interventions at a local level. The aim of this study was to determine the species diversity and abundance, biting ...
• hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole 

  Mambwe, Dickson; Coertzen, Dina; Leshabane, Meta Kgaogelo; Mulubwa, Mwila; Njoroge, Mathew; Gibhard, Liezl; Girling, Gareth; Wicht, Kathryn J.; Lee, Marcus C.S.; Wittlin, Sergio; Moreira, Diogo Rodrigo Magalhaes; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2024-03)

  Please read abstract in the article.
• Characterizing the thermal phase behaviour of fipronil polymorphs 

  Moyo, Dennis Simbarashe; Van der Merwe, Elizabet Margaretha; Rademeyer, Melanie; Malan, F.P. (Frederick); Atanasova, Maria T.; Mapossa, António Benjamim; Focke, Walter Wilhelm (Springer, 2023-07)

  This manuscript reports the investigation of the polymorphic behaviour of fipronil using a systematic comparison of the thermochemical and structural properties of different crystal forms obtained in this study as well as ...
• Maternal exposure to pyrethroid insecticides during pregnancy and respiratory allergy symptoms among children participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) 

  Elsiwi, Basant; Eskenazi, Brenda; Bornman, Maria S. (Riana); Obida, Muvhulawa; Kim, Joanne; Moodie, Erica E.M.; Mann, Koren K.; Chevrier, Jonathan (Elsevier, 2024-02)

  BACKGROUND : Pyrethroid insecticides use for indoor residual spraying (IRS) in malaria-endemic areas results in high levels of exposure to local populations. Pyrethroids may cause asthma and respiratory allergies but ...
• The association between long-term DDT or DDE exposures and an altered sperm epigenome-a cross-sectional study of Greenlandic Inuit and South African VhaVenda men 

  Lismer, Ariane; Shao, Xiaojian; Dumargne, Marie-Charlotte; Lafleur, Christine; Lambrot, Romain; Chan, Donovan; Toft, Gunnar; Bonde, Jens Peter; Macfarlane, Amanda J.; Bornman, Maria S. (Riana); Aneck-Hahn, Natalie Hildegard; Patrick, Sean Mark; Bailey, Janice M.; De Jager, Christiaan; Dumeaux, Vanessa; Trasler, Jacquetta M.; Kimmins, Sarah (National Institute of Environmental Health Sciences, 2024-01)

  Please read abstract in the article.
• School and community driven dengue vector control and monitoring in Myanmar : study protocol for a cluster randomized controlled trial 

  Overgaard, Hans J.; Linn, Nay Yi Yi; Kyaw, Aye Mon Mon; Braack, L.E.O.; Tin, Myo Win; Bastien, Sheri; Velde, Fiona Vande; Echaubard, Pierre; Zaw, Win; Mukaka, Mavuto; Maude, Richard (Taylor and Francis, 2023-08)

  BACKGROUND : Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective preventive drugs and the newly ...

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