• Detection of insect-specific flaviviruses in mosquitoes (Diptera: Culicidae) in northeastern regions of South Africa 

  Guarido, Milehna M.; Govender, Kamini; Riddin, Megan A.; Schrama, Maarten; Gorsich, Erin E.; Brooke, Basil D.; Almeida, Antonio Paulo Gouveia; Venter, Marietjie (MDPI, 2021-10)

  Mosquitoes in the Aedes and Culex genera are considered the main vectors of pathogenic flaviviruses worldwide. Entomological surveillance using universal flavivirus sets of primers in mosquitoes can detect not only ...
• Targeted screening of 11 bisphenols and 7 plasticizers in food composites from Canada and South Africa 

  Tian, Lei; Zheng, Jingyun; Pineda, Marco; Yargeau, Viviane; Furlong, Daniel; Chevrier, Jonathan; Bornman, Maria S. (Riana); Obida, Muvhulawa; Goodyer, Cindy Gates; Bayen, Stephane (Elsevier, 2022-08)

  A sensitive method based on ultrasound-assisted liquid extraction coupled with liquid chromatography was applied to screen 18 plastic-related contaminants in 168 food composites (namely fish fillets, chicken breast, canned ...
• Assessing the external exposome using wearable passive samplers and high-resolution mass spectrometry among South African children participating in the VHEMBE study 

  Koelmel, Jeremy P.; Lin, Elizabeth Z.; DeLay, Kayley; Williams, Antony J.; Zhou, Yakun; Bornman, Maria S. (Riana); Obida, Muvhulawa; Chevrier, Jonathan; Godri Pollitt, Krystal J. (American Chemical Society, 2022-01)

  Children in low- and middle-income countries are often exposed to higher levels of chemicals and are more vulnerable to the health effects of air pollution. Little is known about the diversity, toxicity, and dynamics of ...
• Aedes species (Diptera: Culicidae) ecological and host feeding patterns in the north-eastern parts of South Africa, 2014–2018 

  Guarido, Milehna M.; Riddin, M.A. (Megan); Johnson, Todd; Braack, L.E.O.; Schrama, M.; Gorsich, E.E.; Brooke, B.D.; Almeida, Antonio Paulo Gouveia; Venter, Marietjie (BMC, 2021-06)

  BACKGROUND: There is a paucity of recent data and knowledge on mosquito diversity and potential vectors of arboviruses in South Africa, with most of the available data dating back to the 1950s–1970s. Aedes and Culex species ...
• The effect of cattle-administered ivermectin and fipronil on the mortality and fecundity of Anopheles arabiensis Patton 

  Makhanthisa, Takalani Irene; Braack, L.E.O.; Lutermann, Heike (BMC, 2021-07)

  BACKGROUND: Malaria control primarily depends on two vector control strategies: indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs). Both IRS and LLIN target indoor-biting mosquitoes. However, ...
• Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines 

  Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Leshabane, Meta Kgaogelo; Langeveld, Henrico; Cheuka, Peter M.; Dziwornu, Godwin Akpeko; Chibale, Kelly; Birkholtz, Lyn-Marie (Taylor and Francis, 2021)

  The effectiveness of current antimalarial therapies that cure patients of the pathogenic asexual blood stages is rapidly declining due to the spread of antimalarial drug resistance. This requires the development of novel ...
• New amidated 3,6-diphenylated imidazopyridazines with potent antiplasmodium activity are dual inhibitors of Plasmodium phosphatidylinositol-4-kinase and cGMP-dependent protein kinase 

  Cheuka, Peter Mubanga; Centani, Luyanda; Arendse, Lauren B.; Fienberg, Stephen; Wambua, Lynn; Renga, Shoneeze S.; Dziwornu, Godwin Akpeko; Kumar, Malkeet; Lawrence, Nina; Taylor, Dale; Wittlin, Sergio; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-01)

  Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation ...
• Chemogenomic fingerprints associated with stage-specific gametocytocidal compound action against human malaria parasites 

  Niemand, Jandeli; Van Biljon, Riette Andele; Van der Watt, Mariette Elizabeth; Van Heerden, Ashleigh; Reader, Janette; Van Wyk, Roelof Daniel Jacobus; Orchard, Lindsey M.; Chibale, Kelly; Llinas, Manuel; Birkholtz, Lyn-Marie (American Chemical Society, 2021-09)

  Please read abstract in the article.
• Development and validation of a framework to improve neglected tropical diseases surveillance and response at sub-national levels in Kenya 

  Ng'etich, Arthur Kipkemoi Saitabau; Voyi, K.V.V. (Kuku); Mutero, Clifford Maina (PLoS Neglected Tropical Diseases, 2021-10)

  BACKGROUND : Assessment of surveillance and response system functions focusing on notifiable diseases has widely been documented in literature. However, there is limited focus on diseases targeted for elimination or ...
• Feasibility of implementing recommendations to improve neglected tropical diseases surveillance and response in Kenya : a modified Delphi study 

  Ng'etich, Arthur Kipkemoi Saitabau; Voyi, K.V.V. (Kuku); Mutero, Clifford Maina (BMC, 2021-10)

  BACKGROUND : Effective health information systems (HIS) are critical towards achieving timely response to preventive chemotherapy neglected tropical diseases (PC-NTDs) and their eventual elimination. Strengthened HIS enable ...
• Blooming of insecticides from polyethylene mesh and film 

  Mapossa, António Benjamim; Sibanda, Mthokozisi Mayibongwe; Moyo, Dennis Simbarashe; Kruger, Taneshka; Focke, Walter Wilhelm; Androsch, Rene; Boldt, Regine; Wesley-Smith, James (Taylor and Francis, 2021)

  Malaria remains a public health concern with vector control still the vital component of disease prevention, control, and elimination strategies. Recent years has seen a “stalling” in the progress made towards the reduction ...
• Properties of mosquito repellent-plasticized poly(lactic acid) strands 

  Mapossa, António Benjamim; Lopez-Beceiro, Jorge; Diaz-Diaz, Ana Maria; Artiaga, Ramon; Moyo, Dennis Simbarashe; Mphateng, Thabang N.; Focke, Walter Wilhelm (MDPI Publishing, 2021-09-28)

  Poly(lactic acid) (PLA) is an attractive candidate for replacing petrochemical polymers because it is fully biodegradable. This study investigated the potential of PLA as a sustainable and environmentally friendly ...
• Are individuals willing to pay for community-based eco-friendly malaria vector control strategies? A case of mosquito larviciding using plant-based biopesticides in Kenya 

  Diiro, Gracious M.; Kassie, Menale; Muriithi, Beatrice W.; Gathogo, Nancy G.; Kidoido, Michael; Marubu, Rose; Ochola, John Bwire; Mutero, Clifford Maina (MDPI, 2020-10-16)

  This study was carried out to assess individuals’ willingness to pay (WTP) for UZIMAX, a novel plant-based biopesticide developed for malaria vector control. The biopesticide is estimated to kill up to 100% of Anopheles ...
• Development, characterization and modeling of mosquito repellent release from microporous devices 

  Sitoe, Alcides Everildo José; Mapossa, António Benjamim; Focke, Walter Wilhelm; Muiambo, Herminio; Androsch, René; Wesley-Smith, James (Wiley, 2020-12)

  Nanocomposite strands with mosquito repellent DEET or Icaridin incorporated in a poly(ethylene-co-vinyl acetate) (EVA) matrix, with either pyrogenic silica or an organoclay as a nanofiller, were prepared by a twin-screw ...
• Estimating binary liquid composition from density and refractive index measurements : a comprehensive review of mixing rules 

  Pretorius, Franco; Focke, Walter Wilhelm; Androsch, Rene; Du Toit, Elizabeth Louisa (Elsevier, 2021-04)

  A comprehensive review of refractive index mixing rules of binary solutions is presented. All published mixing rules, with the exception of the Wiener mixing rule, can be reformulated into expressions with a linear dependence ...
• Antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains inhibit microtubule and hemozoin formation : structure–activity relationship and in vivo oral efficacy studies 

  Dziwornu, Godwin Akpeko; Coertzen, Dina; Leshabane, Meta Kgaogelo; Korkor, Constance M.; Cloete, Cleavon K.; Njoroge, Mathew; Gibhard, Liezl; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Wittlin, Sergio; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-04)

  A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure–activity ...
• Assessment of surveillance core and support functions regarding neglected tropical diseases in Kenya 

  Ng’etich, Arthur K.S.; Voyi, K.V.V. (Kuku); Mutero, Clifford Maina (BioMed Central, 2021-01)

  BACKGROUND : Effective surveillance and response systems are vital to achievement of disease control and elimination goals. Kenya adopted the revised guidelines of the integrated disease surveillance and response system ...
• Evaluation of health surveillance system attributes : the case of neglected tropical diseases in Kenya 

  Ng’etich, Arthur K.S.; Voyi, K.V.V. (Kuku); Mutero, Clifford Maina (BioMed Central, 2021-02)

  BACKGROUND : Control of preventive chemotherapy-targeted neglected tropical diseases (PC-NTDs) relies on strengthened health systems. Efficient health information systems provide an impetus to achieving the sustainable ...
• A systematic review on improving implementation of the revitalised integrated disease surveillance and response system in the African region : a health workers' perspective 

  Ng’etich, Arthur K.S.; Voyi, K.V.V. (Kuku); Kirinyet, Ruth C.; Mutero, Clifford Maina (Public Library of Science, 2021-03)

  BACKGROUND : The revised integrated disease surveillance and response (IDSR) guidelines adopted by African member states in 2010 aimed at strengthening surveillance systems critical capacities. Milestones achieved through ...
• Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box 

  Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)

  Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...

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