Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by UP Author "Van Heerden, Ashleigh"

Browsing Research Articles (UP Centre for Sustainable Malaria Control (UP CSMC)) by UP Author "Van Heerden, Ashleigh"

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  • Chemogenomic fingerprints associated with stage-specific gametocytocidal compound action against human malaria parasites 
    Niemand, Jandeli; Van Biljon, Riette Andele; Van der Watt, Mariette Elizabeth; Van Heerden, Ashleigh; Reader, Janette; Van Wyk, Roelof Daniel Jacobus; Orchard, Lindsey M.; Chibale, Kelly; Llinas, Manuel; Birkholtz, Lyn-Marie (American Chemical Society, 2021-09)
    Please read abstract in the article.
  • Machine learning approaches identify chemical features for stage-specific antimalarial compounds 
    Van Heerden, Ashleigh; Turon, Gemma; Duran-Frigola, Miquel; Pillay, Nelishia; Birkholtz, Lyn-Marie (American Chemical Society, 2023-11-07)
    Efficacy data from diverse chemical libraries, screened against the various stages of the malaria parasite Plasmodium falciparum, including asexual blood stage (ABS) parasites and transmissible gametocytes, serve as a ...
  • Machine learning uses chemo-transcriptomic profiles to stratify antimalarial compounds with similar mode of action 
    Van Heerden, Ashleigh; Van Wyk, Roelof Daniel Jacobus; Birkholtz, Lyn-Marie (Frontiers Media, 2021-06)
    The rapid development of antimalarial resistance motivates the continued search for novel compounds with a mode of action (MoA) different to current antimalarials. Phenotypic screening has delivered thousands of promising ...
  • Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box 
    Reader, Janette; Van der Watt, Mariette Elizabeth; Taylor, Dale; Le Manach, Claire; Mittal, Nimisha; Ottilie, Sabine; Theron, Anjo; Moyo, Phanankosi; Erlank, Erica; Nardini, Luisa; Venter, Nelius; Lauterbach, Sonja; Bezuidenhout, Belinda; Horatscheck, Andre; Van Heerden, Ashleigh; Spillman, Natalie J.; Cowell, Anne N.; Connacher, Jessica I.; Opperman, Daniel; Orchard, Lindsey M.; Llinas, Manuel; Istvan, Eva S.; Goldberg, Daniel E.; Boyle, Grant A.; Calvo, David; Mancama, Dalu; Coetzer, Theresa L.; Winzeler, Elizabeth A.; Duffy, James; Koekemoer, Lizette L.; Basarab, Gregory; Chibale, Kelly; Birkholtz, Lyn-Marie (Nature Publishing Group, 2021-01)
    Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium. Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic ...