dc.contributor.author |
Mokgotho, Matlou Phineas
|
|
dc.contributor.author |
Gololo, Stanley Sechene
|
|
dc.contributor.author |
Masoko, Peter
|
|
dc.contributor.author |
Mdee, Ladislaus Kakore
|
|
dc.contributor.author |
Mbazima, Vusi
|
|
dc.contributor.author |
Shai, Leshweni Jeremia
|
|
dc.contributor.author |
Bagla, Victor Patrick
|
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dc.contributor.author |
Eloff, Jacobus Nicolaas
|
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dc.contributor.author |
Mampuru, Leseilane
|
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dc.date.accessioned |
2013-10-28T07:48:33Z |
|
dc.date.available |
2013-10-28T07:48:33Z |
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dc.date.issued |
2013 |
|
dc.description.abstract |
Senna italica, a member of the Fabaceae family (subfamily Caesalpiniaceae), is widely used in South African traditional medicine
to treat a number of disease conditions. Aqueous extracts of the plant are mainly used to treat sexually transmitted infections
and intestinal complications. The roots of S. italica were ground to a fine powder and sequentially extracted with n-hexane,
dichloromethane, acetone, and methanol using serial exhaustive extraction (SEE) method. Thin layer chromatography was used
to analyse the phytochemical composition of the extracts and DPPH radical scavenging method to detect the presence of
antioxidant compounds. The bioassay guided fractionation of the acetone fraction afforded an antioxidant compound with free
radical scavenging activity.The isolated compoundwas subsequently identified as 3,4????,5-trihydroxystilbene (resveratrol).This study
represents the first report of the stilbene resveratrol in S. italica. |
en |
dc.description.librarian |
am2013 |
en |
dc.description.librarian |
mn2013 |
|
dc.description.sponsorship |
The National Research Foundation (NRF) South Africa
(Gun no. N710), the Department of Biochemistry, Microbiology
and Biotechnology, University of Limpopo, and Phytomedicine
Programme, University of Pretoria. |
en |
dc.description.uri |
http://www.hindawi.com/journals/ecam/ |
en |
dc.identifier.citation |
Mokgoth, MP, Gololo, SS, Masoko, P, Mdee, LK, Mbazima, V, Shai, LJ, Bagla, VP, Eloff, JN & Mampuru, L 2013, 'Isolation and chemical structural characterisation of a compound with antioxidant activity from the roots of Senna italica', Evidence-Based Complementary and Alternative Medicine, vol. 2013, no. ID 519174, pp. 1-6. |
en |
dc.identifier.issn |
1741-427X (print) |
|
dc.identifier.issn |
1741-4288 (online) |
|
dc.identifier.other |
10.1155/2013/519174 |
|
dc.identifier.other |
7005589445 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/32170 |
|
dc.language.iso |
en |
en |
dc.publisher |
Hindawi Publishing Corporation |
en |
dc.rights |
© 2013 Matlou Phineas Mokgotho et al. This is an open access article distributed under the Creative Commons
Attribution License |
en |
dc.subject |
Traditional medicine |
en |
dc.subject |
Stilbene resveratrol |
en |
dc.subject |
Senna italica |
en |
dc.subject |
South Africa |
en_ZA |
dc.subject.lcsh |
Alternative medicine -- South Africa |
en |
dc.subject.lcsh |
Materia medica, Vegetable |
en |
dc.title |
Isolation and chemical structural characterisation of a compound with antioxidant activity from the roots of Senna italica |
en |
dc.type |
Article |
en |