Isolation and chemical structural characterisation of a compound with antioxidant activity from the roots of Senna italica

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Mokgotho, Matlou Phineas
Gololo, Stanley Sechene
Masoko, Peter
Mdee, Ladislaus Kakore
Mbazima, Vusi
Shai, Leshweni Jeremia
Bagla, Victor Patrick
Eloff, Jacobus Nicolaas
Mampuru, Leseilane

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Hindawi Publishing Corporation

Abstract

Senna italica, a member of the Fabaceae family (subfamily Caesalpiniaceae), is widely used in South African traditional medicine to treat a number of disease conditions. Aqueous extracts of the plant are mainly used to treat sexually transmitted infections and intestinal complications. The roots of S. italica were ground to a fine powder and sequentially extracted with n-hexane, dichloromethane, acetone, and methanol using serial exhaustive extraction (SEE) method. Thin layer chromatography was used to analyse the phytochemical composition of the extracts and DPPH radical scavenging method to detect the presence of antioxidant compounds. The bioassay guided fractionation of the acetone fraction afforded an antioxidant compound with free radical scavenging activity.The isolated compoundwas subsequently identified as 3,4󸀠????,5-trihydroxystilbene (resveratrol).This study represents the first report of the stilbene resveratrol in S. italica.

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Keywords

Traditional medicine, Stilbene resveratrol, Senna italica, South Africa

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Citation

Mokgoth, MP, Gololo, SS, Masoko, P, Mdee, LK, Mbazima, V, Shai, LJ, Bagla, VP, Eloff, JN & Mampuru, L 2013, 'Isolation and chemical structural characterisation of a compound with antioxidant activity from the roots of Senna italica', Evidence-Based Complementary and Alternative Medicine, vol. 2013, no. ID 519174, pp. 1-6.