Browsing Research Articles (Neurology) by Type "Article"

Browsing Research Articles (Neurology) by Type "Article"

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  • AIDS-related progressive multifocal leukoencephalopathy (PML) : a retrospective study from Pretoria, South Africa 
    Schutte, Clara-Maria; Ranchhod, N.; Kakaza, Mandisa; Pillay, M. (Health and Medical Publishing Group, 2013-06)
    INTRODUCTION AND OBJECTIVES: Progressive multifocal leukoencephalopathy (PML), caused by the John Cunningham (JC) virus, results from lytic infection of predominantly oligodendrocytes. Following the HIV pandemic, the ...
  • Analysis of HIV-related mortality data in a tertiary South African neurology unit, 2006 - 2012 
    Schutte, Clara-Maria (Health and Medical Publishing Group, 2013-11)
    BACKGROUND. South Africa (SA) has a high prevalence of HIV infection with almost 11% of the population aged >2 years living with HIV. At the Steve Biko Academic Hospital, Pretoria, the Neurology Department has seen a steady ...
  • Awaking a sleeping epidemic 
    Van Coller, Riaan; Van Rensburg, Elna; Schutte, Clara-Maria; Brink, Delene; Welthagen, Gerhard Frederick; Dove, Mike G. (South African Medical Association, 2007-04)
    Two patients with African sleeping sickness (SS) presented to the neurology unit, Pretoria Academic Hospital, during 2004 and 2005. SS has shown a recent resurgence, with epidemics in the Sudan, Angola and the Democratic ...
  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) 
    Retief, Chris; Schutte, Clara-Maria; Baker, Malcolm Kevin (Health and Medical Publishing Group, 2009-06)
    BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco-encephalopathy (CADASIL) is a hereditary autosomal dominant non-atherosclerotic nonamyloid cerebral arteriopathy. The disease was ...
  • Clinical findings and genetic screening for copy number variation mutations in a cohort of South African patients with Parkinson’s disease 
    Mahne, A.C.; Carr, J.A.; Bardien, S.; Schutte, Clara-Maria (Health and Medical Publishing Group, 2016-06)
    BACKGROUND. Parkinson’s disease (PD), with a prevalence of up to 4% in Western countries, appears to be less common in Africa, possibly in part because of genetic factors. African studies investigating the genetic causation ...
  • Comparison of HTLV-associated myelopathy (HAM) in HIV-positive and HIV-negative patients at a tertiary South African hospital 
    Schutte, Clara-Maria; Townsend, T.; Van Coller, Riaan; Olorunju, Steve A.S. (Health and Medical Publishing Group, 2013-01)
    BACKGROUND. HTLV-1 associated myelopathy (HAM), or tropical spastic paraparesis, is caused by a retrovirus, the human T-cell lymphotropic virus (HTLV). Although patients with HAM and HIV infection have been described, to ...
  • Eryptosis as a marker of Parkinson’s disease 
    Pretorius, Etheresia; Swanepoel, A.C. (Albe Carina); Buys, A.V. (Antonia Vergina); Vermeulen, Natasha; Duim, Wiebren; Kell, Douglas B. (Impact Journals, 2014-10)
    A major trend in recent Parkinson’s disease (PD) research is the investigation of biological markers that could help in identifying at‐risk individuals or to track disease progression and response to therapies. Central ...
  • Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2 
    Corbett, Mark A.; Kroes, Thessa; Veneziano, Liana; Bennett, Mark F.; Florian, Rahel; Schneider, Amy L.; Coppola, Antonietta; Licchetta, Laura; Franceschetti, Silvana; Suppa, Antonio; Wenger, Aaron; Mei, Davide; Pendziwiat, Manuela; Kaya, Sabine; Delledonne, Massimo; Straussberg, Rachel; Xumerle, Luciano; Regan, Brigid; Crompton, Douglas; Van Rootselaar, Anne-Fleur; CorrelL, Anthony; Catford, Rachael; Bisulli, Francesca; Chakraborty, Shreyasee; Baldassari, Sara; Tinuper, Paolo; Barton, Kirston; Carswell, Shaun; Smith, Martin; Berardelli, Alfredo; Carroll, Renee; Gardner, Alison; Friend, Kathryn L.; Blatt, Ilan; Lacomino, Michele; Di Bonaventura, Carlo; Striano, Salvatore; Buratti, Julien; Keren, Boris; Nava, Caroline; Forlani, Sylvie; Rudolf, Gabrielle; Hirsch, Edouard; Leguern, Eric; Labauge, Pierre; Balestrini, Simona; Sander, Josemir W.; Afawi, Zaid; Helbig, Ingo; Ishiura, Hiroyuki; Tsuji, Shoji; Sisodiya, Sanjay M.; Casari, Giorgio; Sadleir, Lynette G.; Van Coller, Riaan; Tijssen, Marina A.J.; Klein, Karl Martin; Van den Maagdenberg, Arn M.J.M.; Zara, Federico; Guerrini, Renzo; Berkovic, Samuel F.; Pippucci, Tommaso; Canafoglia, Laura (Nature Research, 2019-10)
    Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures. Four independent loci have been ...
  • Isolated posterior fossa involvement of progressive multifocal leucoencephalopathy in HIV : a case series with review of the literature 
    Mudau, Adziambei; Suleman, Farhana Ebrahim; Schutte, Clara-Maria; Lockhat, Zarina I. (Health and Medical Publishing Group, 2017-11-14)
    Progressive multifocal leucoencephalopathy (PML) is a progressive demyelinating condition resulting from infection with the John Cunningham virus and precipitated by immunocompromised states. The HIV pandemic, especially ...
  • Life-threatening Listeria meningitis : need for revision of South African acute bacterial meningitis treatment guidelines 
    Schutte, Clara-Maria; Van der Meyden, C.H. (Kees); Kakaza, Mandisa; Lockhat, Zarina I.; Van der Walt, Elizabeth (Health and Medical Publishing Group, 2019)
    BACKGROUND: The recent listeriosis outbreak in South Africa (SA) received widespread attention in the media. More than 1 000 laboratoryconfirmed cases of listeriosis occurred during an 18-month period, with a case fatality ...
  • Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV 
    Hiesgen, Juliane; Variava, Ebrahim (Health and Medical Publishing Group, 2015-06-26)
    We report the case of an HIV-positive female patient with neurofibromatosis type 1 who was treated for recurrent peptic ulcer disease and later developed diabetes mellitus and chronic diarrhoea. A metastasising somatostatinoma ...
  • Platelet hyperactivity and fibrin clot structure in transient ischemic attack individuals in the presence of metabolic syndrome : a microscopy and thromboelastography (R) study 
    Van Rooy, Mia-Jeanne; Duim, Wiebren; Ehlers, Rene; Buys, Antoinette V.; Pretorius, Etheresia (BioMed Central, 2015)
    BACKGROUND : Strokes are commonly preceded by transient ischemic attacks (TIAs). TIA is often associated with metabolic syndrome (causing chronic inflammation), resulting in a proinflammatory- and procoagulantenvironment. The ...
  • A putative founder effect for Parkinson's disease in South African Afrikaners 
    Carr, Jonathan; Van Coller, Riaan (Health and Medical Publishing Group, 2014-06)
    Neurodegenerative diseases are important causes of disability and death, with prominent examples including Alzheimer’s disease, Parkinson’s disease (PD) and motor neuron disease. Although familial clustering of these ...
  • The role of vasopressin in olfactory and visual processing 
    Wacker, Douglas; Ludwig, Mike (Springer, 2019-01)
    Neural vasopressin is a potent modulator of behaviour in vertebrates. It acts at both sensory processing regions and within larger regulatory networks to mediate changes in social recognition, affiliation, aggression, ...
  • Severe neuropathy due to inhalant abuse in adolescents from Pretoria 
    Schutte, Clara-Maria; Naidoo, Jayendra; Kakaza, Mandisa; Pillay, M.; Hiesgen, Juliane (MedPharm Publications, 2015)
    Inhalation of volatile agents, or solvent abuse, is a dangerous pastime practised by many young adolescents in various parts of the world. Benzine, a distillate of petroleum, is a cheap and readily available solvent that ...
  • Severe porphyric neuropathy – importance of screening for porphyria in Guillain-Barré syndrome 
    Schutte, Clara-Maria; Van der Meyden, C.H. (Kees); Van Niekerk, Linette; Kakaza, Mandisa; Van Coller, Riaan; Ueckermann, Veronica; Oosthuizen, Nicholette M. (Health and Medical Publishing Group, 2016-01)
    The hepatic porphyrias are a group of rare metabolic disorders, each of which is associated with a specific enzymatic alteration in the haem biosynthesis pathway. In South Africa (SA), a high incidence of variegate porphyria ...
  • A South African family with oculopharyngeal muscular dystrophy : clinical and molecular genetic characteristics 
    Schutte, Clara-Maria; Dorfling, Cecilia Maria; Van Coller, Riaan; Honey, E.M.; Van Rensburg, Elizabeth J. (Health and Medical Publishing Group, 2015-07)
    Autosomal dominantly inherited oculopharyngeal muscular dystrophy (OPMD) is caused by a trinucleotide repeat expansion in exon 1 of the polyadenylate binding protein nuclear 1 (PABPN1) gene on chromosome 14q. A large ...
  • South African guideline on deep brain stimulation for Parkinson’s disease 
    Anderson, D.G.; Van Coller, Riaan; Carr, J. (Health and Medical Publishing Group, 2017-11)
    BACKGROUND : Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life. Although the motor aspects of the illness are typically successfully treated with medications ...