Hiesgen, Juliane; Schutte, Clara-Maria(South African Medical Association, 2023-03)
Since the identification of anti-N-methyl-D-aspartate (NMDA) receptor antibodies about 15 years ago, many patients with rapidly progressing psychiatric symptoms, abnormal movements, seizures or unexplained coma, have been ...
Hiesgen, Juliane; Schutte, Clara-Maria(South African Medical Association, 2023-03)
Since the identification of anti-N-methyl-D-aspartate (NMDA) receptor antibodies about 15 years ago, many patients with rapidly
progressing psychiatric symptoms, abnormal movements, seizures or unexplained coma have been ...
Hiesgen, J.; Schutte, Clara-Maria(South African Medical Association, 2023-04)
Autoimmune encephalitis (AE) represents a growing number of severe autoimmune-inflammatory diseases affecting both the white and
grey matter of the brain. In part 1 of this series, we focused on the epidemiology, ...
Munsami, Lyneshree; Schutte, Clara-Maria; De Villiers, Maryke; Hiesgen, Juliane(AOSIS, 2023-01-19)
BACKGROUND : The neuropsychiatric side effects of efavirenz occur mainly early during treatment
and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity
causing ataxia and encephalopathy. ...
Lech, James C.; Halma, Matthew T.J.; Obajuluwa, Adejoke O.; Baker, Malcolm Kevin; Hamblin, Michael R.(Sage, 2023-04)
BACKGROUND : The relationship between the quality of the learning environment and student outcomes is receiving more serious attention from educational psychologists, neurologists, ophthalmologists, orthopedists, surgeons, ...
Hiesgen, Juliane; Annor, T.N.(Health and Medical Publishing Group, 2023-01)
Posterior reversible encephalopathy syndrome (PRES) is an uncommon, subacute neurological disorder that presents radiologically with
a pattern of bilateral parieto-occipital areas of vasogenic oedema. Conditions commonly ...
Behçet’s disease is a rare, systemic variable vessel vasculitis mostly seen in patients from
the Middle East, Northern Africa and Central Asia. Neuro-Behçet disease (NBD) is often diagnosed in patients with known Behçet’s ...
A pathological hallmark of the neurodegenerative disorder, Parkinson's disease (PD), is aggregation of toxic forms of the presynaptic protein, α-synuclein in structures known as Lewy bodies. α-Synuclein pathology is found ...
BACKGROUND : Bobble-head doll syndrome is a rare neurological syndrome presenting with repetitive anteroposterior head movements. It is usually associated with expansile cystic lesions in the third ventricular region.
CASE ...
Myoclonus is a complex disorder of rapid repetitive muscle jerks that can occur in proximal or distal appendicular or axial muscles. It can be of cortical, sub-cortical or spinal cord origin; part of progressive and severely ...
Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor
usually from the second decade of life and overt myoclonic or generalised tonic-clonic seizures.
Four independent loci have been ...
Schutte, Clara-Maria; Van der Meyden, C.H. (Kees); Kakaza, Mandisa; Lockhat, Zarina I.; Van der Walt, Elizabeth(Health and Medical Publishing Group, 2019)
BACKGROUND: The recent listeriosis outbreak in South Africa (SA) received widespread attention in the media. More than 1 000 laboratoryconfirmed cases of listeriosis occurred during an 18-month period, with a case fatality ...
Mahungu, Amokelani C.; Anderson, David G.; Rossouw, Anastasia C.; Van Coller, Riaan; Carr, Jonathan A.; Ross, Owen A.; Bardien, Soraya(Elsevier, 2020-04)
Sequence variants in glucocerebrosidase (GBA) are a major genetic risk factor for Parkinson's disease (PD), and display ethnic-dependent frequencies, for example, variants such as p.N370S and 84insGG are common in Ashkenazi ...
Du Toit, Nicola; Van Coller, Riaan; Anderson, David G.; Carr, Jonathan; Bardien, Soraya(Springer, 2019-10)
G2019S in LRRK2 is the most common mutation associated with Parkinson’s disease (PD). Highest frequencies are in North African Arabic (30–41%) and Ashkenazi Jewish (6–30%) populations, mostly due to founder effects. Here, ...
Neural vasopressin is a potent modulator of behaviour in vertebrates. It acts at both sensory processing regions and within larger
regulatory networks to mediate changes in social recognition, affiliation, aggression, ...
Anderson, D.G.; Van Coller, Riaan; Carr, J.(Health and Medical Publishing Group, 2017-11)
BACKGROUND : Parkinson’s disease (PD) is a common neurodegenerative disease, associated with severe impairment of quality of life.
Although the motor aspects of the illness are typically successfully treated with medications ...
Mudau, Adziambei; Suleman, Farhana Ebrahim; Schutte, Clara-Maria; Lockhat, Zarina I.(Health and Medical Publishing Group, 2017-11-14)
Progressive multifocal leucoencephalopathy (PML) is a progressive demyelinating
condition resulting from infection with the John Cunningham virus and precipitated
by immunocompromised states. The HIV pandemic, especially ...
Mitochondrial neurogastrointestinal encephalopathy (MNGIE), usually an autosomal-recessive inherited condition, causes gastrointestinal dysmotility, ophthalmoplegia, ptosis, leukoencephalopathy and neuropathy. The chromosome ...
The diagnosis of porphyria remains challenging as the condition is characterized by a myriad of clinical and biochemical features. More importantly, an acute attack is associated with increased morbidity and mortality. ...
AIM : This retrospective cohort study analyzes the impact of possible risk factors on the survival chance of patients with cryptococcal meningitis. These factors include the patient's socio-economic background, age, gender, ...