dc.contributor.author |
Engelbrecht, Susan
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dc.contributor.author |
Laten, Janetta D.
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dc.contributor.author |
Smith, Tracey-Lee
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dc.contributor.author |
Janse van Rensburg, Estrelita
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dc.date.accessioned |
2007-07-03T12:23:19Z |
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dc.date.available |
2007-07-03T12:23:19Z |
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dc.date.issued |
1995-10 |
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dc.description |
This article was co-written by Prof Janse van Rensburg before she joined the University of Pretoria. |
en |
dc.description.abstract |
All subtypes of HIV-1 have been identified in Africa. The envelope glycoprotein of the HIV-1 is the most variable region of the virus, with the third variable region, including the V3 loop, a major target of vaccine research. This paper reports the identification of the HIV-1 subtypes present in 14 viral strains, isolated between 1984 and 1992 in South Africa. HIV-1 strains were isolated routinely at Tygerberg hospital in the Western Cape region, with genomic DNA isolated from virus-infected cultures. After presenting the distance calculations and describing the tree constructions and bootstrap analysis, the authors emphasize the need for ongoing molecular epidemiological analysis of HIV-1 subtypes to track the current epidemic in South Africa. More rapid methods will facilitate subtyping to monitor the circulation and spread of HIV-1 subpopulations in the country. |
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dc.format.extent |
8503 bytes |
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dc.format.mimetype |
application/pdf |
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dc.identifier.citation |
Engelbrecht, S, Laten, JD, Smith, TL & Janse van Rensburg, E 1995, 'Identification of env subtypes in fourteen HIV type 1 isolates from South Africa', AIDS Research and Human Retroviruses, vol. 11, no. 10, pp. 1269-1271. [http://www.liebertpub.com/publication.aspx?pub_id=2] |
en |
dc.identifier.issn |
0889-2229 |
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dc.identifier.uri |
http://hdl.handle.net/2263/2862 |
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dc.language.iso |
en |
en |
dc.publisher |
Mary Ann Liebert |
en |
dc.rights |
Mary Ann Liebert
Publisher prohibits open access to the full text of this article. |
en |
dc.subject |
HIV |
en |
dc.subject |
Genetics |
en |
dc.subject |
Viral diseases |
en |
dc.subject.lcsh |
AIDS vaccines -- Research -- South Africa |
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dc.subject.lcsh |
HIV infections -- South Africa |
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dc.title |
Identification of env subtypes in fourteen HIV type 1 isolates from South Africa |
en |
dc.type |
Article |
en |