Please be advised that the site will be down for maintenance on Sunday, September 1, 2024, from 08:00 to 18:00, and again on Monday, September 2, 2024, from 08:00 to 09:00. We apologize for any inconvenience this may cause.
dc.contributor.author | Scriba, Thomas Jens![]() |
|
dc.contributor.author | De Villiers, Tania![]() |
|
dc.contributor.author | Treurnicht, Florette K.![]() |
|
dc.contributor.author | Zur Megede, Jan![]() |
|
dc.contributor.author | Barnett, Susan W.![]() |
|
dc.contributor.author | Engelbrecht, Susan![]() |
|
dc.contributor.author | Janse van Rensburg, Estrelita![]() |
|
dc.date.accessioned | 2007-06-29T12:29:40Z | |
dc.date.available | 2007-06-29T12:29:40Z | |
dc.date.issued | 2002-01 | |
dc.description | This article was written by Prof Janse van Rensburg before she joined the University of Pretoria. | en |
dc.description.abstract | Human immunodeficiency virus type 1 (HIV-1) subtype C has become the major etiological agent in the global and especially African epidemic. To gain better understanding of the genetic diversity and rapid transmission of HIV-1 subtype C, we have characterized the complete 59 long terminal repeat (LTR) region along with the regulatory genes tat and rev as well as the accessory gene nef of 14 South African HIV-1 subtype C isolates. Phylogenetic analysis revealed a subtype C 59 LTR cluster, as well as subclustering of our nef sequences with various subtype C strains separate from the India and China subclusters. At least 3 NF-kB sites were present in the 59 LTR of most isolates and 13 isolates had the subtype C-specific Rev truncation. Some length variation in exon 2 and the absence of a critical cysteine were found in Tat. Residue variation in the myristoylation signal and motifs involved in CD4 and MHC-I down-regulation was recorded in our nef gene sequences. | en |
dc.description.sponsorship | South African AIDS Vaccine Initiative (SAAVI) and the Poliomyelitis Research Foundation. | en |
dc.format.extent | 11637 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Scriba, TJ, De Villiers, T, Treurnicht, FK, Zur Megede, J, Barnett, SW, Engelbrecht, S & Janse van Rensburg, E 2002, 'Characterization of the South African HIV type 1 subtype C complete 5' long terminal repeat, nef, and regulatory genes', Aids Research and Human Retroviruses, vol.18, no. 2, pp.149-159. [http://www.liebertonline.com/loi/aid] | en |
dc.identifier.issn | 0889-2229 | |
dc.identifier.other | 10.1089/08892220252779692 | |
dc.identifier.uri | http://hdl.handle.net/2263/2847 | |
dc.language.iso | en | en |
dc.publisher | Mary Ann Liebert | en |
dc.rights | Mary Ann Liebert The publisher prohibits open access to the full text of this article. | en |
dc.subject.lcsh | HIV infections -- South Africa | |
dc.subject.lcsh | AIDS (Disease) -- South Africa | |
dc.subject.lcsh | Amino acid sequence | |
dc.title | Characterisation of the South African HIV-1 subtype C complete 5’ LTR, nef and regulatory genes | en |
dc.type | Article | en |