Browsing Research Articles (Internal Medicine) by UP Author "Dlamini, Zodwa"

Browsing Research Articles (Internal Medicine) by UP Author "Dlamini, Zodwa"

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  • Cervical cancer in low and middle‑income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020)
    Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more common and accounts for 70% of all cases. In 2018 ...
  • The dual protease inhibitor lopinavir/ritonavir (LPV/r) exerts genotoxic stress on lung cells 
    Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020-12)
    The Sub-Saharan countries, particularly South Africa has the largest number of people living with HIV, accompanied by the largest antiretroviral treatment (ART) programme in the world. The Highly Active Antiretroviral ...
  • Efavirenz and lopinavir/ritonavir alter cell cycle regulation in lung cancer 
    Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Frontiers Media, 2020-08)
    Highly active anti-retroviral treatment (HAART) is currently the most effective treatment for HIV/AIDS. Additionally, HIV positive patients receiving HAART have a better health-related quality of life (HRQoL). Cancers ...
  • Efavirenz induces DNA damage response pathway in lung cancer 
    Marima, Rahaba; Hull, Rodney; Dlamini, Zodwa; Penny, Clement (Impact Journals, 2020-10)
    The cell-cycle related genes are potential gene targets in understanding the effects of efavirenz (EFV) in lung cancer. The present study aimed at investigating the expression changes of cell-cycle related genes in ...
  • Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis 
    Marima, Rahaba; Hull, Rodney; Penny, Clement; Dlamini, Zodwa (Elsevier, 2021-01)
    Aurora Kinase B (AURKB) and Mitotic Arrest Deficient 2 Like 2 (MAD2L2) are emerging anticancer therapeutic targets. AURKB and MAD2L2 are the least well studied members of their protein families, compared to AURKA and ...
  • A multinational review : oesophageal cancer in low to middle-income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Hussain, Showket; Kibiki, Gibson; Bates, David O.; Dlamini, Zodwa (Spandidos, 2020-10)
    Oesophageal cancer (OC) is an aggressive neoplasm that manifests in the gastrointestinal tract and is the result of numerous factors that can contribute to the development of the disease. These may include old age, nutritional ...
  • Pathway mapping reveals antiretroviral treatments' targeted cell cycle regulation in lung cancer 
    Marima, Rahaba; Hull, Rodney; Kandhavelu, Jeyalakshmi; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020)
    The human cell cycle is a tightly regulated process with checkpoints in place to ensure genomic integrity. Cyclin/cyclin dependent kinases (CDKs) complexes drive the progression of the cell cycle while CDK-inhibitors (CDKIs) ...
  • Role and merits of green based nanocarriers in cancer treatment 
    Elbagory, Abdulrahman M.; Marima, Rahaba; Dlamini, Zodwa (MDPI, 2021-11-13)
    The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These “smart” vehicles enhance the dissolution and the ...