Browsing Internal Medicine by Title

Browsing Internal Medicine by Title

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  • Obstructive sleep apnoea and hypertension 
    Ker, James A. (New Media Publishing, 2018-03)
    OSAHS raises the mean 24-hour blood pressure (BP) by 5mmHg to 10mmHg and the blood pressure increase is more in those patients with >20% arterial oxygen desaturation per hour of sleep. This rise in mean BP can lead to 20% ...
  • Obstructive sleep apnoea and obesity 
    Tintinger, Gregory Ronald; Pretorius, L.; Labadarios, D. (Health and Medical Publishing Group, 2011)
    The global obesity epidemic continues to gain momentum, and South Africa is one of those countries with an extremely high prevalence of obesity. The reported association between obstructive sleep apnoea (OSA) and obesity ...
  • Off target or wrong target 
    Van Zyl, Danie G. (Clinics Cardiv, 2008-06)
    No abstract available
  • Optimal glucose control in type 2 diabetes mellitus - a guide for the family practitioner 
    Van Zyl, Danie G. (Medpharm Publishers, 2006-11)
    Type 2 diabetes contributes to significant risk of cardiovascular and micro-vascular complications. The family practitioner plays a significant role in the management of glycaemic control and thereby reducing the related ...
  • Outbreak of Ralstonia mannitolilytica bacteraemia in patients undergoing haemodialysis at a tertiary hospital in Pretoria, South Africa 
    Said, Mohamed; Van Hougenhouck-Tulleken, W.G. (Wesley); Naidoo, Rashmika; Mbelle, Nontombi Marylucy; Ismail, Farzana (BMC, 2020-07)
    BACKGROUND: Ralstonia species are Gram-negative bacilli of low virulence. These organisms are capable of causing healthcare associated infections through contaminated solutions. In this study, we aimed to determine the ...
  • An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia 
    Repsold, Lisa; Pool, Roger; Karodia, Mohammed; Tintinger, Gregory Ronald; Joubert, Annie M. (BioMed Central, 2017-10-10)
    Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related ...
  • P300 event-related potentials in normal-hearing adults with Type 2 diabetes mellitus 
    Van der Westhuizen, Natasha; Biagio-de Jager, Leigh; Rheeder, Paul (American Speech-Language-Hearing Association, 2020-06)
    BACKGROUND : P300 event-related potentials can be used to measure auditory processing speed, working memory, and attention. PURPOSE : The purpose of the study was to compare P300 event-related potentials in normal-hearing ...
  • Pathway mapping reveals antiretroviral treatments' targeted cell cycle regulation in lung cancer 
    Marima, Rahaba; Hull, Rodney; Kandhavelu, Jeyalakshmi; Dlamini, Zodwa; Penny, Clement (Elsevier, 2020)
    The human cell cycle is a tightly regulated process with checkpoints in place to ensure genomic integrity. Cyclin/cyclin dependent kinases (CDKs) complexes drive the progression of the cell cycle while CDK-inhibitors (CDKIs) ...
  • Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM 
    Ahmed, Marwan Awad; Muntingh, George L.; Rheeder, Paul (Hindawi Publishing Corporation, 2017-08-27)
    Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following ...
  • Pharmaceutical drugs in the treatment of STEMI 
    Ker, James A. (New Media Publishing, 2016-08)
    Our concept of ST-segment Elevated Myocardial Infarction (STEMI) refers to when coronary blood supply decreases abruptly after a thrombotic occlusion. The underlying mechanism leading to the thrombotic event is an unstable ...
  • The pleural effusion in HIV - an approach to diagnosis 
    Mostert, Chris J.; Pannell, N. (OpenJournals Publishing, 2009-07)
    HIV is one of the most prevalent diseases and causes of mortality in sub-Saharan Africa. Pleural disease is common in the population of this region, especially pleural effusion. The disease is associated with a significant ...
  • Pneumolysin activates neutrophil extracellular trap formation 
    Nel, Jan Gert; Theron, Annette J.; Durandt, Chrisna; Tintinger, Gregory Ronald; Pool, Roger; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Wiley, 2016-06)
    The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil extracellular trap (NET) formation in vitro. Isolated human blood neutrophils ...
  • Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Theron, Annette J.; Tintinger, Gregory Ronald; Pool, Roger; Richards, Guy A.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2017-06)
    OBJECTIVES: Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the ...
  • Pneumolysin mediates platelet activation in vitro 
    Nel, Jan Gert; Durandt, Chrisna; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2016-08)
    This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply [10–80 nanograms (ng)/ml], platelet activation and cytosolic Ca2+ concentrations ...
  • Points to consider in cardiovascular disease risk management among patients with rheumatoid arthritis living in South Africa, an unequal middle income country 
    Solomon, Ahmed; Stanwix, Anne E.; Castaneda, Santos; Llorca, Javier; Gonzalez-Juanatey, Carlos; Hodkinson, Bridget; Romela, Benitha; Ally, Mahmood Moosa Tar Mahomed; Maharaj, Ajesh B.; Van Duuren, Elsa M.; Ziki, Joyce J.; Seboka, Mpoti; Mohapi, Makgotso; Jansen Van Rensburg, Barend J.; Tarr, Gareth S.; Makan, Kavita; Balton, Charlene; Gogakis, Aphrodite; González-Gay, Miguel A.; Dessein, Patrick H. (BioMed Central, 2020-06)
    BACKGROUND: It is plausible that optimal cardiovascular disease (CVD) risk management differs in patients with rheumatoid arthritis (RA) from low or middle income compared to high income populations. This study aimed at ...
  • Post-procedural Bacillus cereus septic arthritis in a patient with systemic lupus erythematosus 
    Mitton, Barend C.; Rule, Roxanne; Mbelle, Nontombi Marylucy; Van Hougenhouck-Tulleken, W.G. (Wesley); Said, Mohamed (AOSIS Open Journals, 2020-08-20)
    INTRODUCTION : Bacillus species are often considered as contaminants when cultured from clinical samples. Bacillus cereus may be a pathogen in certain circumstances and is known to cause musculoskeletal infections. This ...
  • The prevalence and association of low testosterone levels in a South African male, diabetic, urban population 
    Kemp, Tanja; Rheeder, Paul (Medpharm Publications, 2015-07)
    BACKGROUND : According to the literature, low serum testosterone levels are associated with diabetes mellitus. No or minimal data exist for its prevalence or predictors in South Africa. DESIGN : This was a cross-sectional ...
  • The prevalence and associations of erectile dysfunction in a South African male diabetic urban population 
    Kemp, Tanja; Rheeder, Paul (MedPharm Publications, 2015)
    BACKGROUND : Erectile dysfunction (ED) is a common condition in patients with type 1 or type 2 diabetes mellitus. The prevalence and predictors in our patient population are unknown since minimal data exist for this ...
  • Prevalence of and risk factors for gestational diabetes mellitus in South Africa 
    Dias, Stephanie Charmaine; Adam, Sumaiya; Rheeder, Paul; Pheiffer, Carmen (Health and Medical Publishing Group, 2019-07)
    Gestational diabetes mellitus (GDM) is associated with adverse maternal, fetal and perinatal complications. Without appropriate glucose management, women with GDM and their offspring have an increased risk of developing ...
  • Prevalence of coeliac disease in children and adolescents with type 1 diabetes mellitus in a tertiary hospital in South Africa 
    Karsas, Maria; Terblanche, Alta J.; Kemp, Tanja; Van Dyk, Jacobus C. (Health and Medical Publishing Group, 2021-12-01)
    Background. International literature has shown the prevalence of coeliac disease (CD) in children and adolescents with diabetes to range from 1 - 10%. Prevalence rates in African countries are limited or unknown. Objective. ...