Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM

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Authors

Ahmed, Marwan Awad
Muntingh, George L.
Rheeder, Paul

Journal Title

Journal ISSN

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Publisher

Hindawi Publishing Corporation

Abstract

Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.

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Keywords

Peripheral neuropathy (PN), Type 2 diabetes mellitus (T2DM), Vitamin B12 deficiency, Hyperhomocysteinemia, Risk, Folate, Mellitus, Prevalence, Homocysteine, Racial differences, Cobalamin deficiency

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Citation

Ahmed, M.A., Muntingh, G.L. & Rheeder, P. 2017, 'Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM', International Journal of Endocrinology, vol. 2017, art. no. 2452853, pp. 1-6.