Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM

Ahmed, Marwan Awad; Muntingh, George L.; Rheeder, Paul

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Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM

Ahmed, Marwan Awad; Muntingh, George L.; Rheeder, Paul

URI: http://hdl.handle.net/2263/62241

Date: 2017-08-27

Abstract:

Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.

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