Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM
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Date
Authors
Ahmed, Marwan Awad
Muntingh, George L.
Rheeder, Paul
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi Publishing Corporation
Abstract
Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12
deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin
B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of
topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.
Description
Keywords
Peripheral neuropathy (PN), Type 2 diabetes mellitus (T2DM), Vitamin B12 deficiency, Hyperhomocysteinemia, Risk, Folate, Mellitus, Prevalence, Homocysteine, Racial differences, Cobalamin deficiency
Sustainable Development Goals
Citation
Ahmed, M.A., Muntingh, G.L. & Rheeder, P. 2017, 'Perspectives on peripheral neuropathy as a consequence of metformin-induced vitamin B12 deficiency in T2DM', International Journal of Endocrinology, vol. 2017, art. no. 2452853, pp. 1-6.