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Research Articles (Obstetrics and Gynaecology): Recent submissions

  • Enhancing cervical cancer prevention in South African women : primary HPV mRNA screening with different genotype combinations 
    Sorbye, Sveinung Wergeland; Falang, Bente Marie; Botha, Matthys H.; Snyman, Leon Cornelius; Van der Merwe, Haynes; Visser, Cathy; Richter, Karin Louise; Dreyer, Greta (MDPI, 2023-11-17)
    BACKGROUND : Cervical cancer prevention in regions with limited access to screening and HPV vaccination necessitates innovative approaches. This study explored the potential of a test-and-treat strategy using mRNA HPV tests ...
  • Mapping of radiation oncology and gynecologic oncology services available to treat the growing burden of cervical cancer in Africa 
    Anakwenze, Chidinma P.; Allanson, Emma; Ewongwo, Agnes; Lumley, Christian; Bazzett-Matabele, Lisa; Msadabwe, Susan C.; Kamfwa, Paul; Shouman, Tarek; Lombe, Dorothy; Rubagumya, Fidel; Polo, Alfredo; Ntekim, Atara; Vanderpuye, Verna; Ghebre, Rahel; Kochbati, Lofti; Awol, Munir; Gnangnon, Freddy Houehanou Rodrigue; Snyman, Leon Cornelius; Domgue, Joel Fokom; Incrocci, Luca; Ndlovu, Ntokozo; Razakanaivo, Malala; Abdel-Wahab, May; Trimble, Edward; Schmeler, Kathleen; Simonds, Hannah; Grover, Surbhi (Elsevier, 2024-03)
    PURPOSE: To meet the demand for cervical cancer care in Africa, access to surgical and radiation therapy services needs to be understood. We thus mapped the availability of gynecologic and radiation therapy equipment and ...
  • Comparison of obstetric and perinatal outcomes in women with diabetes at Steve Biko Academic Hospital 
    Malaza, Nompumelelo; Pheiffer, Carmen; Dias, S.; Adam, Sumaiya (Health and Medical Publishing Group, 2023-06)
    BACKGROUND : Diabetes and obesity in pregnancy have been associated with increased rates of adverse maternal and neonatal outcomes compared with women with normoglycaemia and normal weight. OBJECTIVE : To investigate the ...
  • A research agenda to improve incidence and outcomes of assisted vaginal birth 
    Betrán, Ana Pilar; Torloni, Maria Regina; Althabe, Fernando; Altieri, Elena; Arulkumaran, Sabaratnam; Ashraf, Fatema; Bailey, Patricia; Bucagu, Maurice; Clark, Emma; Changizi, Nasrin; Churchill, Robyn; Dominico, Sunday; Downe, Soo; Draycott, Tim; Faye, Arfang; Feeley, Claire; Geelhoed, Diederike; Gherissi, Atf; Gholbzouri, Karima; Grupta, Gagan; Hailegebriel, Tedbabe Degefie; Hanson, Claudia; Hartmann, Katharina; Hassan, Lubna; Hofmeyr, George Justus; Jayathilaka, Anoma Chandani; Kabore, Charles; Kidula, Nancy; Kingdon, Carol; Kuzmenko, Oleg; Lumbiganon, Pisake; Mola, Glen D.L.; Moran, Allisyn; De Muncio, Bremen; Nolens, Barbara; Opiyo, Newton; Pattinson, Robert Clive; Romero, Mariana; Van Roosmalen, Jos; Siaulys, Monica M.; Camelo, Jose Simon; Smith, Jeffrey; Sobel, Howard L.; Sobhy, Soha; Sosa, Claudio; Souza, Joao Paulo; Hoope-Bender, Petra Ten; Thangaratinam, Shakila; Varallo, John; Wright, Alison; Yates, Ann; Oladapo, Olufemi O. (World Health Organization, 2023-11)
    Access to emergency obstetric care, including assisted vaginal birth and caesarean birth, is crucial for improving maternal and childbirth outcomes. However, although the proportion of births by caesarean section has ...
  • Implementation of continuous-wave Doppler ultrasound to detect the high-risk foetus in the low-risk mother : lessons from South Africa 
    Hlongwane, T.M.A.G. (Tsakane); Pattinson, Robert Clive; Bergh, Anne-Marie (BMC, 2023-05-27)
    INTRODUCTION : Detecting the risk of stillbirth during pregnancy remains a challenge. Continuous-wave Doppler ultrasound (CWDU) can be used to screen for placental insufficiency, which is a major cause of stillbirths in ...
  • A high fat, high sugar diet induces hepatic peroxisome proliferator-activated receptor gamma coactivator 1-alpha promoter hypermethylation in male Wistar rats 
    Abrahams, Yoonus; Willmer, Tarryn; Patel, Oelfah; Samodien, Ebrahim; Muller, Christo J.F.; Windvogel, Shantal; Johnson, Rabia; Pheiffer, Carmen (Elsevier, 2023-11)
    Previously we reported that a high fat, high sugar (HFHS) diet induced adiposity, hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in male Wistar rats. In the present study, the mechanisms ...
  • Utility of extended HPV genotyping as primary cervical screen in an unscreened population with high HIV co-infection rate 
    Botha, Matthys Hendrik; Van der Merwe, Frederick H.; Snyman, Leon Cornelius; Dreyer, Gerrit J.; Visser, Cathy; Dreyer, Greta (Lippincott, Williams & Wilkins, 2023-07)
    OBJECTIVE : Screening with primary human papillomavirus (HPV) testing has been evaluated in highly prescreened populations with lower HPV and HIV prevalence than what is the case in South Africa. High prevalence of HPV and ...
  • Integrated growth assessment in the first 1000 days of life : an interdisciplinary conceptual framework 
    Nel, Sanja; Pattinson, Robert Clive; Vannevel, Valerie; Feucht, Ute; Mulol, Helen; Wenhold, F.A.M. (Friedeburg Anna Maria) (Cambridge University Press, 2023-08)
    OBJECTIVES : Prenatal growth affects short- and long-term morbidity, mortality and growth, yet communication between prenatal and postnatal healthcare teams is often minimal. This paper aims to develop an integrated, ...
  • Cerebral palsy and its medicolegal implications in low-resource settings – the need to establish causality and revise criteria to implicate intrapartum hypoxia : a narrative review 
    Bhorat, I.; Buchmann, E.; Soma-Pillay, Priya; Nicolaou, E.; Pistorius, L.; Smuts, Izelle; Velaphi, S. (South African Medical Association, 2023-07)
    The objective of this study was to establish scientific causality and to devise criteria to implicate intrapartum hypoxia in cerebral palsy (CP) in low-resource settings, where there is potential for an increase in damaging ...
  • Cytology compared with Hybrid Capture 2 human papilloma virus cervical cancer screening in HIV positive and HIV negative South African women 
    Snyman, Leon Cornelius; Richter, Karin Louise; widowi; Dreyer, Gerrit; Botha, Matthys Hendrik; Van der Merwe, F. Haynes; Visser, Cathy; Dreyer, Greta (BMJ Publishing, 2023-05)
    OBJECTIVES : Cervical cancer is preventable and caused by persistent infection with oncogenic human papilloma virus (HPV) types. HPV screening is more sensitive and is the preferred screening test. HPV screening data are ...
  • 25-Hydroxycholecalciferol inhibits cell growth and induces apoptosis in SiHa cervical cells via autocrine vitamin D metabolism 
    Punchoo, Rivak; Dreyer, Greta; Pillay, Tahir S. (MDPI, 2023-03)
    Preclinical studies show that the anticancer actions of vitamin D metabolites are mediated by apoptosis, inhibition of cell proliferation and induction of cell cycle arrest. Cervical cancer cells express an autocrine vitamin ...
  • Protocol for developing a core outcome set for male infertility research : an international consensus development study 
    Rimmer, Michael P.; Howie, Ruth A.; Anderson, Richard A.; Barratt, Christopher L.R.; Barnhart, Kurt T.; Beebeejaun, Yusuf; Bertolla, Ricardo Pimenta; Bhattacharya, Siladitya; Bjorndahl, Lars; Bortoletto, Pietro; Brannigan, Robert E.; Cantineau, Astrid E.P.; Caroppo, Ettore; Collura, Barbara L.; Coward, Kevin; Eisenberg, Michael L.; De Geyter, Christian; Goulis, Dimitrios G.; Henkel, Ralf R.; Ho, Vu N.A.; Hussein, Alayman F.; Huyser, Carin; Kadijk, Jozef H.; Kamath, Mohan S.; Khashaba, Shadi; Kobori, Yoshitomo; Kopeika, Julia; Kucuk, Tansu; Lujan, Saturnino; Matsaseng, Thabo Christopher; Mathur, Raj S.; McEleny, Kevin; Mitchell, Rod T.; Mol, Ben W.; Murage, Alfred M.; Ng, Ernest H.Y.; Pacey, Allan; Perheentupa, Antti H.; Du Plessis, Stefan; Rives, Nathalie; Sarris, Ippokratis; Schlegel, Peter N.; Shabbir, Majid; Smiechowski, Maciej; Subramanian, Venkatesh; Sunkara, Sesh K.; Tarlarzis, Basil C.; Tuttelmann, Frank; Tuttelmann, Frank; Vail, Andy; Van Wely, Madelon; Vazquez-Levin, Monica H.; Vuong, Lan N.; Alex Y. Wang; Wang, Rui; Zini, Armand; Farquhar, Cindy M.; Niederberger, Craig; Duffy, James M.N. (Oxford University Press, 2022-03)
    STUDY QUESTION : We aim to develop, disseminate and implement a minimum data set, known as a core outcome set, for future male infertility research. WHAT IS KNOWN ALREADY : Research into male infertility can be challenging ...
  • Severe acute respiratory syndrome coronavirus 2 infection and pregnancy in Sub-Saharan Africa : a 6-country retrospective cohort analysis 
    Nachega, Jean B.; Sam-Agudu, Nadia A.; Machekano, Rhoderick N.; Rosenthal, Philip J.; Schell, Sonja; De Waard, Liesl; Bekker, Adrie; Gachuno, Onesmus W.; Kinuthia, John; Mwongeli, Nancy; Budhram, Samantha; Vannevel, Valerie; Soma-Pillay, Priya; Prozesky, Hans W.; Taljaard, Jantjie; Parker, Arifa; Agyare, Elizabeth; Opoku, Akwasi Baafuor; Makarfi, Aminatu Umar; Abdullahi, Asara M.; Adirieje, Chibueze; Ishoso, Daniel Katuashi; Pipo, Michel Tshiasuma; Tshilanda, Marc B.; Nswe, Christian Bongo-Pasi; Ditekemena, John; Sigwadhi, Lovemore Nyasha; Nyasulu, Peter S.; Hermans, Michel P.; Sekikubo, Musa; Musoke, Philippa; Nsereko, Christopher; Agbeno, Evans K.; Yeboah, Michael Yaw; Umar, Lawal W.; Ntakwinja, Mukanire; Mukwege, Denis M.; Birindwa, Etienne Kajibwami; Mushamuka, Serge Zigabe; Smith, Emily R.; Mills, Edward J.; Otshudiema, John Otokoye; Mbala-Kingebeni, Placide; Tamfum, Jean-Jacques Muyembe; Zumla, Alimuddin; Tsegaye, Aster; Mteta, Alfred; Sewankambo, Nelson K.; Suleman, Fatima; Adejumo, Prisca; Anderson, Jean R.; Noormahomed, Emilia V.; Deckelbaum, Richard J.; Stringer, Jeffrey S.A.; Mukalay, Abdon; Taha, Taha E.; Fowler, Mary Glenn; Wasserheit, Judith N.; Masekela, Refiloe; Mellors, John W.; Siedner, Mark J.; Myer, Landon; Kengne, Andre-Pascal; Yotebieng, Marcel; Mofenson, Lynne M.; Langenegger, Eduard; AFREhealth Research Collaboration on COVID-19 and Pregnancy (Oxford University Press, 2022-06-08)
    BACKGROUND : Few data are available on COVID-19 outcomes among pregnant women in sub-Saharan Africa (SSA), where high-risk comorbidities are prevalent. We investigated the impact of pregnancy on SARS-CoV-2 infection and ...
  • Superficial spreading cervical squamous cell carcinoma in situ with extensive endomyometrial infiltration masquerading as a primary endometrial cancer 
    Olivier, H.J.; Snyman, Leon Cornelius; Oliva, E.; Slavik, Tomas (MedPharm Publications, 2022-12)
    The presence of squamous cell carcinoma (SCC) on endometrial histology raises the possibility of a primary endometrial carcinoma, as well as secondary endometrial involvement by SCC from another site, especially the cervix. ...
  • Time- and glucose-dependent differentiation of 3T3-L1 adipocytes mimics dysfunctional adiposity 
    Jackson, Hayley C.; Pheiffer, Carmen; Jack, Babalwa; Africander, Donita (Elsevier, 2023-09)
    The 3T3-L1 murine adipocyte cell line remains one of the most widely used models to study the mechanisms of obesity and related pathologies. Most studies investigate such mechanisms using mature adipocytes that have been ...
  • The impact of climate change on maternal and child health 
    Soma-Pillay, Priya; Wium, L.; Pillay, Yogan (Netherlands Press, 2022-11)
    It can be argued that there are three colliding pandemics that are currently affecting the planet and its people: COVID-19, global inequities and climate change. Regrettably, these are all the result of human action or ...
  • Iron deficiency in women’s health : an understated burden with serious health consequences 
    Dreyer, Greta; Zondagh, Jake (Netherlands Press, 2022-01)
    The importance of iron for overall health in humans cannot be overstated and its extremely widespread biological functions include electron transfer, intercellular signalling, catalysis, and oxygen binding and transport. ...
  • Expressed informed consent for intimate gynaecological examinations 
    Snyman, Leon Cornelius (Netherlands Press, 2022-07)
    The doctor-patient relationship, although extremely important and essential to ensure optimal treatment outcomes, remains complicated. This relationship allows two people, unfamiliar with each other, with different value ...
  • Transverse vaginal septum in a young adolescent : a case report describing a novel approach in the initial surgical management 
    Mbambu, T.; Snyman, Leon Cornelius (Netherlands Press, 2022-01)
    Transverse vaginal septum is a rare congenital anomaly. It is one of the variants of müllerian duct anomalies which results from defective fusion or recanalization of the vaginal and müllerian organs. It can present with ...
  • Placental malaria : a threat to obstetric outcomes 
    Molokoane, Felicia; Seopela, Louisa; Sajo, Adekunle Emmanuel (Netherlands Press, 2022-01)
    Placental malaria occurs when there is sequestration of Plasmodium falciparum infected red blood cells in the placenta. This is the primary mechanism by which malaria in pregnancy perpetuates its adverse perinatal outcomes ...