Browsing Research Articles (Obstetrics and Gynaecology) by UP Author "Mbele, Mzwandile"

Browsing Research Articles (Obstetrics and Gynaecology) by UP Author "Mbele, Mzwandile"

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  • Apoptosis in cancer cells is induced by alternative splicing of hnRNPA2/B1 through splicing of Bcl-x, a mechanism that can be stimulated by an extract of the South African medicinal plant, Cotyledon orbiculata 
    Makhafola, Tshepiso Jan; Mbele, Mzwandile; Yacqub-Usman, Kiren; Hendren, Amy; Haigh, Daisy Belle; Blackley, Zoe; Meyer, Mervin; Mongan, Nigel Patrick; Bates, David Owen; Dlamini, Zodwa (Frontiers Media, 2020-10)
    Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects ...
  • Cervical cancer in low and middle‑income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Kibiki, Gibson; Bates, David Owen; Dlamini, Zodwa (Spandidos, 2020)
    Cervical cancer is a malignant tumour that occurs in the cervix and is classified into two histological types, adenocarcinoma and squamous cell carcinoma (SCC); SCC is more common and accounts for 70% of all cases. In 2018 ...
  • Expression analysis of RbBP6 in human cancers : a prospective biomarker 
    Mbita, Zukile; Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Dlamini, Zodwa (Lippincott, Williams and Wilkins, 2019-09)
    Retinoblastoma binding protein 6 (RBBP6) is a cancer-related protein that has been implicated in the regulation of cell cycle and apoptosis. RBBP6 isoform 1 has been demonstrated to interact with two tumour suppressors, ...
  • HIV-associated cancer biomarkers : a requirement for early diagnosis 
    Dlamini, Zodwa; Mbele, Mzwandile; Makhafola, Tshepiso J.; Hull, Rodney; Marima, Rahaba (MDPI Publishing, 2021-07-29)
    Globally, HIV/AIDS and cancer are increasingly public health problems and continue to exist as comorbidities. The sub-Saharan African region has the largest number of HIV infections. Malignancies previously associated ...
  • A multinational review : oesophageal cancer in low to middle-income countries 
    Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso Jan; Hicks, Chindo; Wang, Shao Ming; Reis, Rui Manuels; Mehrotra, Ravi; Mkhize-Kwitshana, Zilungile; Hussain, Showket; Kibiki, Gibson; Bates, David Owen; Dlamini, Zodwa (Spandidos, 2020-10)
    Oesophageal cancer (OC) is an aggressive neoplasm that manifests in the gastrointestinal tract and is the result of numerous factors that can contribute to the development of the disease. These may include old age, nutritional ...
  • Regulation of alternative splicing in obesity-induced hypertension 
    Dlamini, Zodwa; Hull, Rodney; Makhafola, Tshepiso Jan; Mbele, Mzwandile (Dove Medical Press, 2019)
    Obesity is the result of genetics which predisposes an individual to obesity and environmental factors, resulting in excessive weight gain. A well-established linear relationship exists between hypertension and obesity. ...