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Browsing Research Articles (Obstetrics and Gynaecology) by Author "Pheiffer, Carmen"
Now showing items 1-20 of 27
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Pheiffer, Carmen; Dias, Stephanie; Jack, Babalwa; Malaza, Nompumelelo; Adam, Sumaiya [ (MDPI Publishing, 2021-02)Adiponectin is an adipocyte-derived hormone that plays a critical role in energy homeostasis, mainly attributed to its insulin-sensitizing properties. Accumulating studies have reported that adiponectin concentrations ...
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Dias, Stephanie Charmaine; Adam, Sumaiya; Abrahams, Yoonus; Rheeder, Paul; Pheiffer, Carmen (Public Library of Science, 2021-03)DNA methylation is increasingly recognized as a potential biomarker of metabolic disease. However, there is limited information on the impact of human immunodeficiency virus (HIV) infection on the candidacy of DNA ...
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Dias, Stephanie Charmaine; Adam, Sumaiya; Rheeder, Paul; Louw, Johan; Pheiffer, Carmen (MDPI Publishing, 2019-11-20)Increasing evidence implicate altered DNA methylation in the pathophysiology of gestational diabetes mellitus (GDM). This exploratory study probed the association between GDM and peripheral blood DNA methylation patterns ...
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Adam, Sumaiya; Pheiffer, Carmen; Dias, Stephanie Charmaine; Rheeder, Paul (Taylor and Francis, 2018)BACKGROUND : We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. METHODS : In our case-cohort study in Johannesburg we included women with GDM and controls. ...
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Masete, Matladi Innocent; Dias, Stephanie; Malaza, Nompumelelo; Adam, Sumaiya; Pheiffer, Carmen (Frontiers Media S.A., 2022-07-25)Maternal diabetes is associated with pregnancy complications and poses a serious health risk to both mother and child. Growing evidence suggests that pregnancy complications are more frequent and severe in pregnant women ...
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Pheiffer, Carmen; Dias, Stephanie; Mendham, Amy E.; Jack, Babalwa; Willmer, Tarryn; Eshibona, Nasr; Bendou, Hocine; Pretorius, Ashley; Goedecke, Julia H. (Nature Research, 2022-11-01)The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study aimed to investigate miRNA ...
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Malaza, Nompumelelo; Pheiffer, Carmen; Dias, S.; Adam, Sumaiya (Health and Medical Publishing Group, 2023-06)BACKGROUND : Diabetes and obesity in pregnancy have been associated with increased rates of adverse maternal and neonatal outcomes compared with women with normoglycaemia and normal weight. OBJECTIVE : To investigate the ...
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Adam, Sumaiya; Pheiffer, Carmen; Dias, Stephanie; Hlongwane, T.M.A.G. (Tsakane); Vannevel, Valerie; Soma-Pillay, Priya; Abdullah, Fareed (Frontiers Media SA, 2022-07-13)Despite many advances in medicine we are still faced with emerging pathogens. Pregnant women have been disproportionately affected by previous coronavirus outbreaks. The COVID-19 pandemic has not affected pregnant women ...
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Jack, Babalwa Unice; Ramharack, Pritika; Malherbe, Christiaan; Gabuza, Kwazi; Joubert, Elizabeth; Pheiffer, Carmen (MDPI, 2023-02)Previously, we reported that a crude polyphenol-enriched fraction of Cyclopia intermedia (CPEF), a plant consumed as the herbal tea, commonly known as honeybush, reduced lipid content in 3T3-L1 adipocytes and inhibited ...
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Adam, Sumaiya; Dias, Stephanie Charmaine; Rheeder, Paul; Pheiffer, Carmen (Health and Medical Publishing Group, 2019-07)The prevalence of non-communicable diseases in South Africa (SA) is increasing. Alarmingly, SA is one of the nations with the most obese people in the world. The incidence of gestational diabetes mellitus (GDM) is ...
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Dias, Stephanie Charmaine; Adam, Sumaiya; Van Wyk, Nastasja; Rheeder, Paul; Louw, Johan; Pheiffer, Carmen (Taylor and Francis, 2019)BACKGROUND/OBJECTIVE : Recently, several studies have reported that DNA methylation changes in tissue are reflected in blood, sparking interest in the potential use of global DNA methylation as a biomarker for gestational ...
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Abrahams, Yoonus; Willmer, Tarryn; Patel, Oelfah; Samodien, Ebrahim; Muller, Christo J.F.; Windvogel, Shantal; Johnson, Rabia; Pheiffer, Carmen (Elsevier, 2023-11)Previously we reported that a high fat, high sugar (HFHS) diet induced adiposity, hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in male Wistar rats. In the present study, the mechanisms ...
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Riedel, Sylvia; Pheiffer, Carmen; Johnson, Rabia; Louw, Johan; Muller, Christo J. F. (Frontiers Media S.A., 2022-01-25)Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare systems worldwide. The rising prevalence of obesity, a major risk factor for T2D, is mainly attributed to the adoption of Westernized ...
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Pheiffer, Carmen; Dias, Stephanie Charmaine; Adam, Sumaiya (MDPI, 2020-10)The early detection and management of gestational diabetes mellitus (GDM) is an important public health goal. GDM, which is defined as a glucose intolerance that develops during pregnancy, affects about 14% of pregnancies ...
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Dias, Stephanie; Pheiffer, Carmen; Adam, Sumaiya (MDPI, 2023-09)Gestational diabetes mellitus (GDM) is a growing public health concern that affects many pregnancies globally. The condition is associated with adverse maternal and neonatal outcomes including gestational hypertension, ...
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Pheiffer, Carmen; Dias, Stephanie Charmaine; Rheeder, Paul; Adam, Sumaiya (Springer, 2019-08)BACKGROUND : Recently, we reported that the microRNAs (miRNAs) miR-20a-5p and—to a lesser extent—miR-222-3p hold potential as biomarkers for gestational diabetes mellitus (GDM) in human immunodeficiency virus (HIV)-negative ...
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Dias, Stephanie Charmaine; Pheiffer, Carmen; Abrahams, Yoonus; Rheeder, Paul; Adam, Sumaiya (MDPI Publishing, 2018-09-26)Gestational diabetes mellitus (GDM) is a growing public health problem worldwide. The condition is associated with perinatal complications and an increased risk for future metabolic disease in both mothers and their ...
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Dias, Stephanie Charmaine; Adam, Sumaiya; Rheeder, Paul; Pheiffer, Carmen (Dove Medical Press, 2021)PURPOSE : Gestational diabetes mellitus (GDM) is a growing public health concern. GDM affects approximately 14% of pregnancies globally, and without effective treatment, is associated with short- and long-term complications ...
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Nyawo, Thembeka A.; Pheiffer, Carmen; Mazibuko-Mbeje, Sithandiwe E.; Mthembu, Sinenhlanhla X.H.; Nyambuya, Tawanda M.; Nkambule, Bongani B.; Sadie-Van Gijsen, Hanel; Strijdom, Hans; Tiano, Luca; Dludla, Phiwayinkosi V. (MDPI, 2021-11-04)Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness ...
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Willmer, Tarryn; Oosthuizen, Amberly; Dias, Stephanie; Mendham, Amy E.; Goedecke, Julia H.; Pheiffer, Carmen (Nature Research, 2022)We investigated gluteal (GSAT) and abdominal subcutaneous adipose tissue (ASAT) DNA methylation of FKBP5 in response to a 12-week intervention in African women with obesity, as well as the efect of the rs1360780 single ...
Now showing items 1-20 of 27