dc.contributor.author |
Bipath, Priyesh
|
|
dc.contributor.author |
Viljoen, Margaretha
|
|
dc.contributor.author |
Levay, Peter Ferenc
|
|
dc.date.accessioned |
2012-07-02T11:59:25Z |
|
dc.date.available |
2012-07-02T11:59:25Z |
|
dc.date.issued |
2012-06 |
|
dc.description.abstract |
OBJECTIVES: To compare the value of procalcitonin,
C-reactive protein (CRP) and neopterin as indicators of
immune deficiency, co-infection, efficacy of treatment,
and disease progression, in patients with advanced HIV-1
infection.
DESIGN: Cross-sectional, investigating baseline blood
measurements and clinical observations in 82 HIV-positive
patients divided into an antiretroviral treatment (ART)
group and an ART-naïve group.
SETTING: Secondary general hospital in Pretoria.
RESULTS: Procalcitonin and CRP levels showed no
significant differences between the ART and ART-naïve
groups, and no correlations with CD4 counts or viral loads.
CRP levels were significantly higher with TB co-infection
(p<0.05). Neopterin levels were raised above normal in 92%
of the ART-naïve group and in 75% of the ART group. The
levels were significantly higher (p<0.05) in the ART- naïve
group. Negative correlations were found between neopterin
and CD4 counts for the total patient group (r=-0.482;
p<0.001). Neopterin was significantly (p<0.05) higher in
the HIV/TB co-infection group than in those without TB.
Higher neopterin levels at baseline were associated with a
decline in CD4 counts over the ensuing 6-month period,
and patients with higher baseline neopterin levels developed
more complications over the 6-month period.
CONCLUSIONS: Compared with procalcitonin and CRP,
neopterin appears to be associated with the degree of
immunodeficiency and of co-infection with TB. Neopterin
levels may be investigated further as a measure of disease
progression or treatment response. |
en_US |
dc.description.sponsorship |
The Medical Research Council of
South Africa (MRC grant A0S541) and the South
African Sugar Association (SASA grant 213). |
en_US |
dc.description.uri |
www.sajhivmed.org.za |
en_US |
dc.identifier.citation |
Bipath, P, Viljoen, M & Levay, PF 2012, 'Levels of procalcitonin, C-reactive protein and neopterin in patients with advanced HIV-1 infection', Southern African Journal of HIV Medicine, vol. 13, no. 2, pp. 78-82. |
en_US |
dc.identifier.issn |
1608-9693 (print) |
|
dc.identifier.issn |
2078-6751 (online) |
|
dc.identifier.uri |
http://hdl.handle.net/2263/19285 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Health and Medical Publishing Group |
en_US |
dc.rights |
Health and Medical Publishing Group |
en_US |
dc.subject |
Procalcitonin |
en_US |
dc.subject |
C-reactive protein (CRP) |
en_US |
dc.subject |
Neopterin |
en_US |
dc.subject |
Immune deficiency |
en_US |
dc.subject |
Co-infection |
en_US |
dc.subject |
Efficacy of treatment |
en_US |
dc.subject |
Disease progression |
en_US |
dc.subject |
Advanced HIV-1 infection |
en_US |
dc.title |
Levels of procalcitonin, C-reactive protein and neopterin in patients with advanced HIV-1 infection |
en_US |
dc.type |
Article |
en_US |