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Browsing Research Articles (Immunology) by UP Author "Tintinger, Gregory Ronald"
Now showing items 1-20 of 20
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Cigarette smoke condensate attenuates phorbol ester-mediated neutrophil extracellular trap formation Bokaba, Refilwe Philadelphia; Anderson, Ronald; Theron, Annette J.; Tintinger, Gregory Ronald (Makerere University Medical School, 2017-09)BACKGROUND : Neutrophil extracellular traps (NETs) constitute a network of chromatin fibres containing histone and antimicrobial peptides that are released by activated neutrophils. NETs protect the host against infection ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Richards, G.A.; Theron, Annette J.; Van den Bout, Jan Iman; Anderson, Ronald; Feldman, Charles; Van Zyl Smit, Richard; Chang, Ju-Wei; Tintinger, Gregory (European Respiratory Society, 2023-05)BACKGROUND : Electronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than ...
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Hendricks, Candice Laverne; Herd, Candice Lee; Nel, Marcel; Tintinger, Gregory Ronald; Pepper, Michael Sean (Frontiers Media, 2021-02-19)The pandemic caused by SARS-CoV-2 has infected more than 94 million people worldwide (as of 17 January 2020). Severe disease is believed to be secondary to the cytokine release syndrome (CRS or “cytokine storm”) which ...
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Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Richards, Guy A.; Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (MDPI Publishing, 2018-05-14)Dabigatran is an oral direct thrombin inhibitor, and rivaroxaban, a factor Xa inhibitor. Dabigatran has been implicated in the etiology of acute coronary syndromes and as these occur following inflammatory changes in the ...
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Theron, Annette J.; Feldman, Charles; Richards, Guy A.; Tintinger, Gregory Ronald; Anderson, Ronald (AME Publishing Company, 2019-12)Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of this strategy, ...
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Kwofie, Luyanda Laura Illicia; Rapoport, Bernardo Leon; Fickl, Heidi; Meyer, Pieter Willem Adriaan; Rheeder, Paul; Hlope, H.; Anderson, Ronald; Tintinger, Gregory Ronald (Springer, 2012-04)The soluble Triggering Receptor Expressed on Myeloid cells 1 (sTREM-1) is a useful marker of infection in patients with sepsis, but has not been adequately evaluated in patients with chemotherapy-associated febrile ...
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Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
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Anderson, Ronald; Tintinger, Gregory Ronald; Feldman, Charles (AOSIS Open Journals, 2014-01)Chronic inflammation of both infective and non-infective origin has been implicated in the aetiology of approximately 30% of all human epithelial malignancies. The primary carcinogens are reactive oxygen species (ROS) ...
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Steel, Helen C.; Tintinger, Gregory Ronald; Theron, Annette J.; Anderson, Ronald (Blackwell, 2007-10)Please refer to abstract in article
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Mokgobu, Matlou Ingrid; Anderson, Ronald; Steel, Helen C.; Cholo, Moloko C.; Tintinger, Gregory Ronald; Theron, Annette J. (Taylor and Francis, 2012)Although pro-inflammatory mechanisms have been implicated in the pathogenesis of manganese (Mn²⁺)-related neurological and respiratory disorders, relatively little is known about the potential of this metal to interact ...
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Tintinger, Gregory Ronald; Steel, Helen C.; Theron, Annette J.; Anderson, Ronald (Dove Medical Press, 2008)Unlike most other effector cells of the innate, as well as the adaptive immune systems, the neutrophil is a relatively undiscerning aggressor with scant regard for damage limitation. Although this highly combative, ...
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Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
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Rapoport, Bernardo Leon; Shannon, Vickie R.; Cooksley, Tim; Johnson, Douglas B.; Anderson, Lindsay; Blidner, Ada Gabriela; Tintinger, Gregory Ronald; Anderson, Ronald (Frontiers Media, 2021-10)The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, ...
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Tintinger, Gregory Ronald; Theron, Annette J.; Anderson, Ronald; Potjo, Moliehi (Elsevier, 2007-06-15)Please refer to abstract in article
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Meyer, Pieter Willem Adriaan; Ally, Mahmood Moosa Tar Mahomed; Tikly, Mohammed; Tintinger, Gregory Ronald; Winchow, Lai Ling; Steel, Helen C.; Anderson, Ronald (Hindawi Publishing, 2019)Microbial lipopolysaccharides (LPS) have been implicated in the pathogenesis of rheumatoid arthritis (RA), possibly driving a systemic inflammatory response that may trigger the development and/or exacerbation of the ...
Now showing items 1-20 of 20