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Browsing Research Articles (Immunology) by Subject "Hematopoietic stem and progenitor cells (HSPCs)"

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Lentivector knockdown of CCR5 in hematopoietic stem and progenitor cells confers functional and persistent HIV-1 resistance in humanized mice

Myburgh, Renier; Ivic, Sandra; Gers-Huber, Gustavo; Li, Duo; Audige, Annette; Rochat, Mary-Aude; Jaquet, Vincent; Regenass, Stephan; Manz, Markus G.; Pepper, Michael Sean; Salmon, Patrick; Krause, Karl-Heinz; Speck, Roberto F. (American Society for Microbiology, 2015-07)

Gene-engineered CD34(+) hematopoietic stem and progenitor cells (HSPCs) can be used to generate an HIV-1-resistant immune system. However, a certain threshold of transduced HSPCs might be required for transplantation into ...

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