Browsing Research Articles (Immunology) by Subject "Basal cell carcinoma (BCC)"

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Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma

Malinga, Nonkululeko Z.; Siwele, Shalate C.; Steel, Helen C.; Kwofie, Luyanda Laura Illicia; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon; Kgokolo, C.M. (Elsevier, 2022-05)

Although co-inhibitory immune checkpoint proteins are primarily involved in promoting cell-cell interactions that suppress adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules ...
Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma

Kgokolo, C.M.; Malinga, Nonkululeko Z.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon (Elsevier, 2024-04)

The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells ( n = 7) in a cohort of patients with ...

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