Recently added

Immunology: Recent submissions

  • 2023 updated MASCC/ESMO consensus recommendations : prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting 
    Rapoport, Bernardo Leon; Herrstedt, Jorn; Snow, Rebecca Clark; Radhakrishnan, Venkatraman; Saito, Mitsue; Navari, Rudolph M.; Smit, Teresa (Springer, 2024-01)
    PURPOSE : This review is an update of the MASCC/ESMO 2015 recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea ...
  • T cell responses to SARS-CoV-2 spike cross-recognize Omicron 
    Keeton, Roanne; Tincho, Marius B.; Ngomti, Amkele; Baguma, Richard; Benede, Ntombi; Suzuki, Akiko; Khan, Khadija; Cele, Sandile; Bernstein, Mallory; Karim, Farina; Madzorera, Sharon V.; Moyo-Gwete, Thandeka; Mennen, Mathilda; Skelem, Sango; Adriaanse, Marguerite; Mutithu, Daniel; Aremu, Olukayode; Stek, Cari; Du Bruyn, Elsa; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita R.; Bodenstein, Annie; Van den Berg, Gretha; Mendes, Adriano; Strydom, Amy; Venter, Marietjie; Giandhari, Jennifer; Naidoo, Yeshnee; Pillay, Sureshnee; Tegally, Houriiyah; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Wilkinson, Robert J.; De Oliveira, Tulio; Bekker, Linda‑Gail; Gray, Glenda; Ueckermann, Veronica; Rossouw, Theresa; Boswell, M.T.; Bhiman, Jinal N.; Moore, Penny L.; Sigal, Alex; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Riou, Catherine (Nature Research, 2022-03-17)
    The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations1,2 that contribute to viral escape from antibody neutralization3–6 and reduce vaccine protection from infection7,8. The extent to which other ...
  • Comparative molecular genetics of odontogenic keratocysts in sporadic and syndromic patients 
    Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus (Elsevier, 2023-01)
    Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
  • Immune and metabolic alterations in children with perinatal HIV exposure 
    Du Toit, Louise de Villiers; Prinsloo, Andrea; Steel, Helen C.; Feucht, Ute Dagmar; Louw, Roan; Rossouw, Theresa (MDPI, 2023-02)
    With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV ...
  • Phenylalanine metabolism and tetrahydrobiopterin bio-availability in COVID-19 and HIV 
    Mason, Shayne; Van Reenen, Mari; Rossouw, Theresa; Lindeque, Zander; Louw, Roan (Elsevier, 2023-03)
    Please read abstract in article.
  • Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility 
    Gocz, Balazs; Rumpler, Eva; Sarvari, Miklos; Skrapits, Katalin; Takacs, Szabolcs; Farkas, Imre; Csillag, Veronika; Trinh, Sarolta H.; Bardoczi, Zsuzsanna; Solymosi, Norbert; Poliska, Szilard; Bartoloni, Lucia; Zouaghi, Yassine; Messina, Andrea; Pitteloud, Nelly; Anderson, Ross Calley; Millar, Robert P.; Quinton, Richard; Manchishi, Stephen M.; Colledge, William H.; Hrabovszky, Erik (National Academy of Sciences, 2022-06-28)
    Kisspeptin neurons in the mediobasal hypothalamus (MBH) are critical targets of ovarian estrogen feedback regulating mammalian fertility. To reveal molecular mechanisms underlying this signaling, we thoroughly characterized ...
  • Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 
    Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)
    There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
  • The acidic tumour microenvironment : manipulating the immune response to elicit escape 
    Worsley, Catherine; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2022-05)
    The success of cancer treatment relies on the composition of the tumour microenvironment which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and extracellular matrix components. Barriers to ...
  • The role of Solute Carrier Family 7 Member 8 (SLC7A8) in adipogenesis in vitro and in a murine model of obesity 
    Pitere, Reabetswe (University of Pretoria, 2023)
    Obesity is a pandemic affecting both adults and children with an increasing annual prevalence. Adipogenesis, a process in which adipocyte precursors differentiate into mature adipocytes, is considered an important process ...
  • The effect of cigarette smoke extract on the activity of clarithromycin with anti-pseudomonal agents on growth and biofilm formation of Pseudomonas aeruginosa 
    Sekalo, Lebogang (University of Pretoria, 2023)
    The present study was undertaken with the initial objective of investigating the effects of six primary anti-pseudomonal antibiotics, namely amikacin, cefepime, ciprofloxacin, meropenem, piperacillin and tazobactam, on the ...
  • Influence of mesenchymal stromal cells and 2-methoxyestradiol in a murine model of spontaneous mammary carcinoma 
    Peta, Kimberly Thando (University of Pretoria, 2023)
    Breast cancer (BC) is the most prevalent cancer in females and the leading cause of cancer deaths. Treatment options include mastectomy, chemotherapy, and radiotherapy. While these treatments can improve 5-year survival ...
  • A South African breast implant-associated anaplastic large cell lymphoma : clinical presentation and six-year follow-up 
    Grubnik, Alexandra; Ramdas, Yastira; Van der Bergh, Barend; Nayler, Simon; Benn, Carol-Ann; Rapoport, Bernardo Leon (Hindawi, 2022-05-31)
    Breast augmentation is the most common surgical procedure for women globally, with 1,795,551 cases performed in 2019. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is highly uncommon, with 733 reported ...
  • Shared N417-dependent epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus variants 
    Moyo-Gwete, Thandeka; Madzivhandila, Mashudu; Mkhize, Nonhlanhla N.; Kgagudi, Prudence; Ayres, Frances; Lambson, Bronwen E.; Manamela, Nelia P.; Richardson, Simone, I.; Makhado, Zanele; Van der Mescht, Mieke Adri; De Beer, Zelda; De Villiers, Talita Roma; Burgers, Wendy A.; Ntusi, Ntobeko A.B.; Rossouw, Theresa M.; Ueckermann, Veronica; Boswell, Michael T.; Moore, Penny L. (American Society for Microbiology, 2022-07)
    As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, several variants of concern (VOCs) have arisen which are defined by multiple mutations in their spike proteins. These VOCs have shown ...
  • The effect of acute acid exposure on immunomodulatory protein secretion, cell survival, and cell cycle progression in tumour cell lines 
    Worsley, Catherine M.; Veale, Rob B.; Mayne, Elizabeth S. (Elsevier, 2023-02)
    Cancer develops when multiple systems fail to suppress uncontrolled cell proliferation. Breast cancers and oesophageal squamous cell carcinoma (OSCC) are common cancers prone to genetic instability. They typically occur ...
  • SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity 
    Richardson, Simone I.; Manamela, Nelia P.; Motsoeneng, Boitumelo M.; Kaldine, Haajira; Ayres, Frances; Makhado, Zanele; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Sullivan, Nancy J.; Misasi, John; Gray, Glenda G.; Bekker, Linda‑Gail; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Moore, Penny L. (Cell Press, 2022-02-15)
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic ...
  • SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals 
    Richardson, Simone I.; Madzorera, Tatenda; Spencer, Holly; Manamela, Nelia P.; Van der Mescht, Mieke Adri; Lambson, Bronwen E.; Oosthuysen, Brent; Ayres, Frances; Makhado, Zanele; Moyo-Gwete, Thandeka; Mzindle, Nonkululeko; Motlou, Thopisang; Strydom, Amy; Mendes, Adriano; Tegally, Houriiyah; De Beer, Zelda; De Villiers, Talita Roma; Bodenstein, Annie; Van den Berg, Gretha; Venter, Marietjie; De Oliviera, Tulio; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Moore, Penny L. (Cell Press, 2022-03-24)
    The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown. We ...
  • Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 
    Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)
    The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
  • A case report of post-radiotherapy c-MYC-positive angiosarcoma of the breast 
    Retter, Edna; Benn, Carol-Ann; Maske, Christopher; Rapoport, Bernardo Leon (Karger Publishers, 2022-02-07)
    Angiosarcoma of the breast is an unusual malignancy and carries a poor prognosis, with a 5-year overall survival rate ranging from 27 to 48%. Radiotherapy-induced angiosarcoma (RIAS) of the breast is very uncommon, with ...
  • Social media and COVID-19-perceptions and public deceptions of ivermectin, colchicine and hydroxychloroquine : lessons for future pandemics 
    Schellack, Natalie; Strydom, Morne A.; Pepper, Michael Sean; Herd, Candice Lee; Hendricks, Candice Laverne; Bronkhorst, Elmien; Meyer, Johanna C.; Padayachee, Neelaveni; Bangalee, Varsha; Truter, Ilse; Ellero, Andrea Antonio; Myaka, Thulisa; Naidoo, Elysha; Godman, Brian (MDPI, 2022-04)
    The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This ...
  • Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma 
    Malinga, Nonkululeko Z.; Siwele, Shalate C.; Steel, Helen C.; Kwofie, Luyanda Laura Illicia; Meyer, Pieter Willem Adriaan; Smit, Teresa; Anderson, Ronald; Rapoport, Bernardo Leon; Kgokolo, C.M. (Elsevier, 2022-05)
    Although co-inhibitory immune checkpoint proteins are primarily involved in promoting cell-cell interactions that suppress adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules ...