Angiosarcoma of the breast is an unusual malignancy and carries a poor prognosis, with a
5-year overall survival rate ranging from 27 to 48%. Radiotherapy-induced angiosarcoma (RIAS)
of the breast is very uncommon, with an estimated incidence of 1 in 1,000 cases of breasts
treated with radiotherapy for breast cancer. The increase in radiotherapy usage may lead to
an increased incidence of RIAS. A case presentation of a 67-year-old patient with tubular
adenocarcinoma of the left breast who developed c-MYC-positive RIAS of the breast is presented.
The patient was successfully treated with surgery. We presented a classic case of c-MYC
RIAS. c-MYC was reported to be positive in RIAS and other types of angiosarcomas. Clinical
examination and early detection of RIAS breast angiosarcoma is vital to improving outcomes
in these patients.