Browsing Immunology by Title

Browsing Immunology by Title

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  • Side population : its use in the study of cellular heterogeneity and as a potential enrichment tool for rare cell populations 
    Wolmarans, Elize; Nel, Sulette; Durandt, Chrisna; Mellet, Juanita; Pepper, Michael Sean (Hindawi Publishing Corporation, 2018-12-06)
    There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting. Stem cells are found in virtually all tissues in the human body. As a result, cells isolated from these tissues ...
  • Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome 
    Maione, Luigi; Fevre, Anne; Nettore, Immacolata Cristina; Manilall, Ashmeetha; Francou, Bruno; Trabado, Severine; Bouligand, Jerome; Guiochon-Mantel, Anne; Delemer, Brigitte; Flanagan, Colleen A.; Macchia, Paolo Emidio; Millar, Robert P.; Young, Jacques (Oxford University Press, 2019-01)
    STUDY QUESTION : Does the phenotype of women with normosmic congenital hypogonadotrophic hypogonadism (nCHH) and pituitary resistance to GnRH caused by biallelic mutations in the GnRH receptor (GNRHR) (nCHH/bi-GNRHR) differ ...
  • Similarities between tumour immune response and chronic wound microenvironment : influence of mesenchymal stromal/stem cells 
    Peta, Kimberly; Ambele, Melvin Anyasi; Pepper, Michael Sean (Hindawi, 2021-03-30)
    Tumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate ...
  • Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy regimens: a subgroup analysis from a randomized clinical trial of response in subjects by cancer type 
    Weinstein, Cindy; Jordan, Karin; Green, Stuart; Khanani, Saleem; Beckford-Brathwaite, Elizabeth; Vallejos, Waldimir; Pong, Annpey; Noga, Stephen J.; Rapoport, Bernardo Leon (BioMed Central, 2020-09)
    BACKGROUND: Results from a phase III, randomized, double-blind, active comparator-controlled, parallel-group trial evaluating fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting (CINV) found that ...
  • Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs 
    Pitere, Reabetswe R.; Van Heerden, Marlene B.; Pepper, Michael Sean; Ambele, Melvin Anyasi (MDPI, 2022-02)
    Adipogenesis, through adipocyte hyperplasia and/or hypertrophy, leads to increased adiposity, giving rise to obesity. A genome-wide transcriptome analysis of in vitro adipogenesis in human adipose-derived stromal/stem ...
  • Small molecule follicle-stimulating hormone receptor agonists and antagonists 
    Anderson, Ross Calley; Newton, Claire L.; Millar, Robert P. (Frontiers Media, 2019-01-23)
    The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR ...
  • Social creatures : model animal systems for studying the neuroendocrine mechanisms of social behaviour 
    Robinson, Kelly J.; Bosch, Oliver J.; Levkowitz, Gil; Busch, Karl Emanuel; Jarman, Andrew P.; Ludwig, Mike (Wiley, 2019-12)
    The interaction of animals with conspecifics, termed social behaviour, has a major impact on the survival of many vertebrate species. Neuropeptide hormones modulate the underlying physiology that governs social interactions, ...
  • Social justice and research using human biological material : a right to respond 
    Mahomed, S.; Nothling-Slabbert, Melodie; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-09)
    No abstract available.
  • Social media and COVID-19-perceptions and public deceptions of ivermectin, colchicine and hydroxychloroquine : lessons for future pandemics 
    Schellack, Natalie; Strydom, Morne A.; Pepper, Michael Sean; Herd, Candice Lee; Hendricks, Candice Laverne; Bronkhorst, Elmien; Meyer, Johanna C.; Padayachee, Neelaveni; Bangalee, Varsha; Truter, Ilse; Ellero, Andrea Antonio; Myaka, Thulisa; Naidoo, Elysha; Godman, Brian (MDPI, 2022-04)
    The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This ...
  • Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation 
    Brown, Colin H.; Ludwig, Mike; Tasker, Jeffrey G.; Stern, Javier E. (Wiley, 2020-06)
    Somato‐dendritic secretion was first demonstrated over 30 years ago. However, although its existence has become widely accepted, the function of somato‐dendritic secretion is still not completely understood. Hypothalamic ...
  • A South African breast implant-associated anaplastic large cell lymphoma : clinical presentation and six-year follow-up 
    Grubnik, Alexandra; Ramdas, Yastira; Van der Bergh, Barend; Nayler, Simon; Benn, Carol-Ann; Rapoport, Bernardo Leon (Hindawi, 2022-05-31)
    Breast augmentation is the most common surgical procedure for women globally, with 1,795,551 cases performed in 2019. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is highly uncommon, with 733 reported ...
  • South African guideline for the management of chronic hepatitis B : 2013 
    Spearman, C.W.N.; Sonderup, M.W.; Botha, J.F.; Van der Merwe, Schalk Willem; Song, E.; Kassianides, C.; Newton, K.A.; Hairwadzi, H.N. (Health and Medical Publishing Group, 2013-05)
    Hepatitis B remains a significant yet preventable health issue in South Africa. The introduction of the hepatitis B vaccine into the country some 18 years ago has demonstrated benefit, but the exposure to, and prevalence ...
  • Southern African HIV Clinicians Society guidelines for harm reduction 
    Scheibe, Andrew; Sibeko, Goodman; Shelly, Shaun; Rossouw, Theresa M.; Zishiri, Vincent; Venter, Willem Daniel Francois (Health and Medical Publishing Group, 2020-12-17)
    We support public-health-focused interventions, as opposed to recovery-focused interventions. We support the decriminalisation of drug use as much as we oppose the criminalisation of sex work, mandatory HIV disclosure ...
  • Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database : supporting patient management, surveillance and research in southern Africa 
    Manasa, Justen; Lessells, Richard J.; Rossouw, Theresa M.; Naidu, Kevindra K.; Van Vuuren, Cloete; Goedhals, Dominique; Van Zyl, Gert; Bester, Armand; Skingsley, Andrew; Stoot, Katharine E.; Danaviah, S.; Chetty, Terusha; Singh, Lavanya; Moodley, Pravi; Iwuji, Collins; McGrath, Nuala; Seebregts, Christopher J.; De Oliveira, Tulio (Oxford University Press, 2014)
    Substantial amounts of data have been generated from patient management and academic exercises designed to better understand the human immunodeficiency virus (HIV) epidemic and design interventions to control it. A number ...
  • Spatial analyses of immune cell infiltration in cancer : current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer 
    Page, David B.; Broeckx, Glenn; Jahangir, Chowdhury Arif; Verbandt, Sara; Gupta, Rajarsi R.; Thagaard, Jeppe; Khiroya, Reena; Kos, Zuzana; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R.M.; Botinelly Mendonca Fujimoto, Luciana; Burgues, Octavio; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A.D.; Coosemans, An; Corredor, German; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N.; Elghazawy, Mahmoud; Ely, Scott; Fernandez-Martin, Claudio; Fineberg, Susan; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula I.; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hardas, Alexandros; Hart, Steven N.; Hartman, Johan; Hewitt, Stephen; Hida, Akira I.; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A.M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey I.; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis-Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Salomon, Anne-Vincent; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; Van Der Laak, Jeroen; Van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Adams, Sylvia; Bartlett, John Mark Seaverns; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth; Akturk, Guray; Bouchmaa, Najat (Wiley, 2023-08)
    Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized ...
  • Special edition of the SAMJ devoted to cell and gene therapy 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    BACKGROUND: In South Africa (SA), the largest category of perinatal deaths is unexplained stillbirths. Two-thirds of these occur in the antenatal period and most fetuses are macerated, but at antenatal clinics the mothers ...
  • Spectrum of MYO7A mutations in an indigenous South African population further elucidates the nonsyndromic autosomal recessive phenotype of DFNB2 to include both homozygous and compound heterozygous mutations 
    Kabahuma, Rosemary Ida; Schubert, Wolf-Dieter; Labuschagne, Christiaan; Yan, Denise; Blanton, Susan Halloran; Pepper, Michael Sean; Liu, Xue Zhong (MDPI, 2021-02-15)
    MYO7A gene encodes unconventional myosin VIIA, which, when mutated, causes a phenotypic spectrum ranging from recessive hearing loss DFNB2 to deaf-blindness, Usher Type 1B (USH1B). MYO7A mutations are reported in nine DFNB2 ...
  • Sperm macrocephaly syndrome in the ostrich Struthio camelus : morphological characteristics and implications for motility 
    Du Plessis, Lizette; Bonato, M.; Durandt, Chrisna; Cloete, S.W.P.; Soley, John Thomson (CSIRO Publishing, 2019)
    Sperm macrocephaly syndrome (SMS) is characterised by a high percentage of spermatozoa with enlarged heads and multiple tails, and is related to infertility. Although this multiple sperm defect has been described in other ...
  • A standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences 
    Alcantara, Luiz Carlos Junior; Cassol, Sharon; Libin, Pieter; Deforche, Koen; Pybus, Oliver G.; Van Ranst, Marc; Galvao-Castro, Bernardo; Vandamme, Anne-Mieke; De Oliveira, Tulio (Oxford University Press, 2009-07)
    Human immunodeficiency virus type-1 (HIV-1), hepatitis B and C and other rapidly evolving viruses are characterized by extremely high levels of genetic diversity. To facilitate diagnosis and the development of prevention ...
  • The stem cell regulatory environment in South Africa - cause for concern 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2009-07)
    Every innovation in medicine is met with a mixture of excitement, expectation and a certain degree of apprehension. Nowhere is this more apparent than in the field of cellbased therapy, i.e. the application of cells to ...