Browsing Immunology by Author "Pepper, Michael Sean"

Browsing Immunology by Author "Pepper, Michael Sean"

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  • Establishment and equilibrium levels of deleterious mutations in large populations 
    Viljoen, Johan W.; De Villiers, J Pieter.; Van Zyl, Augustinus J.; Mezzavilla, Massimo.; Pepper, Michael Sean (Nature Research, 2019-07)
    Analytical and statistical stochastic approaches are used to model the dispersion of monogenic variants through large populations. These approaches are used to quantify the magnitude of the selective advantage of a monogenic ...
  • Ethical considerations in the application of cell and gene therapies in children 
    Pepper, Michael Sean; Pope, A.; Kling, S.; Alessandrini, M.; Van Staden, W.; Green, Robin J. (Health and Medical Publishing Group, 2018-12)
    Rapidly evolving fields such as cell and gene therapies that involve state-of-the-art technology hold out possibilities that may be ahead of what ethics, guidelines and the law have considered. This results in a regulatory ...
  • Ethical, legal and social issues in the context of the planning stages of the Southern African Human Genome Programme 
    De Vries, Jantina; Slabbert, Melodie; Pepper, Michael Sean (International Centre of Medicine and Law, 2012)
    As the focus on the origin of modern man appears to be moving from eastern to southern Africa, it is recognised that indigenous populations in southern Africa may be the most genetically diverse on the planet and hence ...
  • Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort 
    Dodgen, Tyren Mark; Drögemöller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Steffens, Francois E.; Cromarty, Allan Duncan; Alessandrini, Marco; Pepper, Michael Sean (Future Medicine, 2015-08)
    AIM : To align predicted and measured CYP2C19 phenotype in a South African cohort. MATERIALS AND METHODS : Genotyping of CYP2C19*2, *3, *9, *15, *17, *27 and *28 was performed using PCR-RFLP, and an Activity Score (AS) ...
  • Exporting DNA – striking a balance between preventing exploitation and promoting innovation 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2017-02)
    DNA contains the blueprint of life. Variations in the script determine the great diversity that characterises our planet. As the analysis of large datasets derived from DNA reveals the hidden secrets of normal and abnormal ...
  • Factors influencing the umbilical cord blood stem cell industry : an evolving treatment landscape 
    Dessels, Carla; Alessandrini, Marco; Pepper, Michael Sean (Wiley Open Access, 2018-09)
    Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem ...
  • Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing 
    Kallmeyer, Karlien; Andre-Levigne, Dominik; Baquie, Mathurin; Krause, Karl-Heinz; Pepper, Michael Sean; Pittet-Cuénod, Brigitte; Modarressi, Ali (AlphaMed Press, 2020-01)
    There is increasing interest in the use of adipose-derived mesenchymal stromal cells (ASCs) for wound repair. As the fate of administered cells is still poorly defined, we aimed to establish the location, survival, and ...
  • Fibroblast-derived extracellular matrix induces chondrogenic differentiation in human adipose-derived mesenchymal stromal/stem cells in vitro 
    Dzobo, Kevin; Turnley, Taegyn; Wishart, Andrew; Rowe, Arielle; Kallmeyer, Karlien; Van Vollenstee, Fiona A.; Thomford, Nicholas Ekow; Dandara, Collet; Chopera, Denis; Pepper, Michael Sean; Parker, M. Iqbal (MDPI Publishing, 2016-08-03)
    Mesenchymal stromal/stem cells (MSCs) represent an area being intensively researched for tissue engineering and regenerative medicine applications. MSCs may provide the opportunity to treat diseases and injuries that ...
  • Gender and sexual diversity – changing paradigms in an ever-changing world 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2015-09)
    Enshrined in the Bill of Rights of South Africa's Constitution are a number of rights that affirm the democratic values of human dignity, equality and freedom. Section 9(3) states that 'The state may not unfairly discriminate ...
  • Gene and cell therapy in South Africa : current status and future prospects 
    Ely, Abdullah; Bloom, Kori; Maepa, Mohube Betty; Mahlangu, John N.; Pepper, Michael Sean; Arbuthnot, P. (Health and Medical Publishing Group, 2019-08)
    South Africa has a high disease burden resulting from communicable and non-communicable diseases. Current therapeutic interventions rarely result in a cure and the associated lifelong treatment places a considerable strain ...
  • The genetics of obesity : the role of the melanocortin 4 receptor 
    Logan, M.G.; Pepper, Michael Sean (Health and Medical Publishing Group, 2010)
    Obesity, which is described clinically by a body mass index (BMI) of > 30 kg/m2 is increasing at an alarming rate, and is recognised as a chronic disease by the World Health Organization (WHO). This epidemic decreases ...
  • Genome technologies, precision medicine and innovative therapies 
    Pepper, Michael Sean (Lynnwood Ridge: Academy of Science South Africa, 2018-09)
    We all share a common ancestry, and nowhere is this more apparent than in our genomes. Despite our differences, most of the information contained in our genomes is highly similar, if not identical. Yet it is the differences ...
  • Genomic sovereignty and the African promise : mining the African genome for the benefit of Africa 
    De Vries, Jantina; Pepper, Michael Sean (BMJ Publishing Group, 2012)
    Scientific interest in genomics in Africa is on the rise with a number of funding initiatives aimed specifically at supporting research in this area. Genomics research on material of African origin raises a number of ...
  • A global comparative overview of the legal regulation of stem cell research and therapy : lessons for South Africa 
    Nothling-Slabbert, Melodie; Pepper, Michael Sean (Health and Medical Publishing Group, 2015-08)
    Stem cell research and its potential translation to regenerative medicine, tissue engineering and cell and gene therapy, have led to controversy and debates similar to the calls nearly 25 years ago for a ban involving ...
  • Haematopoietic stem cell transplantation in South Africa : current limitations and future perspectives 
    Grobbelaar, Simone; Mercier, Anne Elisabeth; Verburgh, Estelle; Brittain, David; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a ...
  • Hemangiomas - current therapeutic strategies 
    Mabeta, Peaceful Lucy; Pepper, Michael Sean (UBC Press, 2011-07)
    Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present ...
  • Heterogeneity of cell therapy products 
    Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
  • Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations 
    Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Wiley, 2019-05)
    BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different ...
  • HIV and haematopoiesis 
    Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)
    Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
  • HLA typing : conventional techniques v. next-generation sequencing 
    Mellet, Juanita; Gray, C.M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need ...