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Browsing Research Articles (Physiology) by Author "Van den Bout, Jan Iman"
Now showing items 1-8 of 8
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Visagie, M.H. (Michelle Helen); Van den Bout, Jan Iman; Joubert, Annie M. (Public Library of Science, 2017-04-14)Clinical trials have revealed that the potential anticancer agent, 2-methoxyestradiol (2ME2) has limitations due to its low bioavailability. Subsequently, 2ME2 derivatives including (8R, 13S,14S,17S)-2-ethyl-13-methyl- ...
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Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
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Visuttijai, Kittichate; Pettersson, Jennifer; Azar, Yashar Mehrbani; Van den Bout, Jan Iman; Orndal, Charlotte; Marcickiewicz, Janusz; Nilsson, Staffan; Hornquist, Michael; Olsson, Bjorn; Ejeskar, Katarina; Behboudi, Afrouz (Public Library of Science, 2016-10-07)Myosin-1C (MYO1C) is a tumor suppressor candidate located in a region of recurrent losses distal to TP53. Myo1c can tightly and specifically bind to PIP2, the substrate of Phosphoinositide 3-kinase (PI3K), and to Rictor, ...
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Nkandeu, D.S. (Danielle Sandra); Van den Bout, Jan Iman; Cronjé, Marianne J.; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Joubert, Anna Margaretha (Karger Publishers, 2018)BACKGROUND : 2-Methoxyestradiol (2ME2) is an endogenous metabolite of 17-β-estradiol with anti-proliferative and anti-angiogenic properties. Due to 2ME2’s rapid metabolism and low oral bioavailability in in vivo settings, ...
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Theron, Anne Elisabeth; Prudent, Renaud; Nolte, Elsie M.; Van den Bout, Jan Iman; Punchoo, Rivak; Marais, Sumari; Du Toit, Peet J.; Hlophe, Yvette Nkondo; Van Papendorp, D.H. (Dirk Hermanus), 1949-; Lafanechere, Laurence; Joubert, Annie M. (Springer, 2015-02)PURPOSE : 2-Methoxyestradiol (2ME) is a promising anticancer agent that disrupts the integrity and dynamics of the spindle network. In order to overcome the pharmacokinetic constraints of this compound, a panel of ...
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Botes, Mandie; Jurgens, Tamarin; Riahi, Zohreh; Visagie, M.H. (Michelle Helen); Janse van Vuuren, Rustelle; Joubert, Annie M.; Van den Bout, Jan Iman (BioMed Central, 2018-11-19)BACKGROUND : 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical application. ...
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Janse van Vuuren, Rustelle; Botes, Mandie; Jurgens, Tamarin; Joubert, Annie M.; Van den Bout, Jan Iman (BioMed Central, 2019-01-03)BACKGROUND : The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In ...
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Van der Bijl, Ivo; Nawaz, Kalim; Kazlauskaite, Ugne; Van Stalborch, Anne-Marieke; Tol, Simon; Jimenez Orgaz, Ana; Van den Bout, Jan Iman; Reinhard, Nathalie R.; Sonnenberg, Arnoud; Margadant, Coert (Elsevier, 2020-11)Collective cell behaviour during embryogenesis and tissue repair requires the coordination of intercellular junctions, cytoskeleton-dependent shape changes controlled by Rho GTPases, and integrin-dependent cell-matrix ...
Now showing items 1-8 of 8